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Identification of clinical subgroups of Type 2 diabetes mellitus and application of pharmacogenetics in development of personalized antidiabetic therapy

 

 

Funding: European Regional Development Fund (ERDF) “On Implementation of Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment”

Project Title: “Identification of clinical subgroups of Type 2 diabetes mellitus and application of pharmacogenetics in development of personalized antidiabetic therapy” 

Project Nr.1.1.1.2/VIAA/2/18/287

Period: 36 months (1st March 2019 – 28 February 2022)

Project costs: 133 806,00 EUR

Project implementer: Dr. biol. Linda Zaharenko

Project Summary:

The project proposes subtyping of Type 2 Diabetes mellitus (T2DM) patients and evaluation of effects of pharmacogenetic markers on patient-significant therapy outcomes and prevention of complications. The stratification of T2DM in a sample of ~ 3 800 patients will be assessed by using data-driven cluster analysis; pharmacogenetic research, investigating the association between clinical outcomes and T2DM susceptibility scores, will be investigated in the subgroup of ~ 1 000 patients with GWAS data. The acquired dataset will be analysed by applying classical statistical analysis and supervised machine learning methods (decision trees and simple neural networks). Identified significant clinical variables and genetic factors will be used to create a model for prediction of the treatment outcomes. Replication of findings will be performed in the GoDARTS dataset with 10 000 GWAS available. Project results will potentially facilitate the development of patient-centred treatment and identification of groups in need for early intensive therapy.

Information published 01.03.2019.

 

1 March 2019 – 31 May 2019

During the 01.03.2019.-31.05.2019. the spectrum of variables and metadata from ‘‘Register of patients with particular diseases, including patients with diabetes mellitus’’ and Genome Database of Latvian Population (LGDB) as well as from Death causes database of the Centre for Disease Prevention and Control were assessed and data analysis and storage methods chosen. The application for the approval of the project by The Central Medical Ethics Committee of Latvia was submitted. The preliminary application for additional retrieval data from UK Biobank data was prepared. The draft of a publication entitled "All-cause mortality risk in adults with and without type 2 diabetes: findings from the Genome Database of the Latvian Population" was prepared according to guidelines of BMC Public Health journal.

Information published 31.05.2019.



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".