Project title: Development of precision medical techniques for the treatment of child malignancies
Period:
First period: 1st February 2023 – 30th June 2023
Second period: 1st March 2024 – 31 December 2024
Project costs:
First period: 163 777,80 EUR
Second period: 228 148,66 EUR
Principal Investigator: Dr. biol. J.Kloviņš
Project summary:
The aim of the project is to increase the competence of health care professionals and scientists in the genetics of child malignancies and to promote the development of a molecular-based anti-inflammatory medical approach in the clinical practice of pediatric oncology in Latvia. The results of this project are aimed at creating a research resource for child malignancies that will provide additional knowledge of the pathogenic mechanisms of child malignancy and contribute to the health care of these patients.
Information published 16.02.2023.
Progress of the project
1st March, 2024 – 31 May, 2024
Advanced data analysis methods have been implemented, including the identification of structural variations and the detection of microsatellite instability. The comparison of obtained results with findings from the Children’s Clinical University Hospital has begun, aiming to validate the chosen methodology. Both prospective and retrospective sample processing and sequencing are ongoing.
Information published 31.05.2024.
Progress of the project:
1 June 2024 – 31 August 2024
Data analysis performed for 100 retrospective patients using advanced data analysis workflow, manuscript preparation is in progress. Electronization of questionnaires and optimization of clinical data exchange are introduced. In addition to this, a research protocol for the direction of intestinal and oral microbiome research has been prepared, which will provide additional knowledge about changes in the composition of the microbiome during therapy. A laboratory protocol for the collection and processing of bone marrow samples has been developed, in accordance with the needs of clinical protocols.
Information published 30.08.2024.