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LATVIAN

BIOMEDICAL

RESEARCH AND STUDY CENTRE

RESEARCH AND EDUCATION IN BIOMEDICINE FROM GENES TO HUMAN

Publications

Zinātniskā raksta, monogrāfijas bibliogrāfiskais apraksts vai intelektuālā īpašuma nosaukumsGadsPubMed
Fridmanis, J., Otikovs, M., Brangulis, K., Tārs, K., Jaudzems, K. Solution NMR structure of Borrelia burgdorferi outer surface lipoprotein BBP28, a member of the mlp protein family (2021) Proteins: Structure, Function and Bioinformatics, 89 (5), pp. 588-594.2021https://pubmed.ncbi.nlm.nih.gov/32949018/
Erenpeisa J., Salmiņa K., Anatskaya O., Cragg M.S. Paradoxes ofcancer: survival at the brink2021https://www.sciencedirect.com/science/article/pii/S1044579X20302698
Saksis, R., Silamikelis, I., Laksa, P., Megnis, K., Peculis, R., Mandrika, I., Rogoza, O., Petrovska, R., Balcere, I., Konrade, I., Steina, L., Stukens, J., Breiksa, A., Nazarovs, J., Sokolovska, J., Pirags, V., Klovins, J., Rovite, V. Medication for Acromegaly Reduces Expression of MUC16, MACC1 and GRHL2 in Pituitary Neuroendocrine Tumour Tissue (2021) Frontiers in Oncology, 10, art. no. 593760.2021https://www.frontiersin.org/articles/10.3389/fonc.2020.593760/full
Mandrika, I., Kumar, S., Zandersone, B., Eranezhath, S.S., Petrovska, R., Liduma, I., Jezupovs, A., Pirags, V., Tracevska, T. Antibacterial and Anti-Inflammatory Potential of Polyherbal Formulation Used in Chronic Wound Healing (2021) 2021, art. no. 9991454, Evidence-based Complementary and Alternative Medicine.2021https://www.hindawi.com/journals/ecam/2021/9991454/
Grigs, O., Bolmanis, E., Galvanauskas, V. Application of in-situ and soft-sensors for estimation of recombinant p. Pastoris gs115 biomass concentration: A case analysis of hbcag (mut+) and hbsag (muts) production processes under varying conditions (2021) 21 (4), art. no. 1268, pp. 1-35. SENSORS.2021https://www.mdpi.com/1424-8220/21/4/1268
Lacson, J.C.A., Zamani, S.A., Froes, L.A.R., Jr, Mitra, N., Qian, L., Doyle, S.H., Azizi, E., Balestrini, C., Bishop, D.T., Bruno, W., Carlos-Ortega, B., Cuellar, F., Cust, A.E., Elder, D.E., Gerdes, A.-M., Ghiorzo, P., Grazziotin, T.C., Gruis, N.A., Hansson, J., Hočevar, M., Höiom, V., Holland, E.A., Ingvar, C., Landman, G., Larre-Borges, A., Mann, G.J., Molgo, M., Moredo, L.F., Olsson, H., Out-Luiting, J.J., Perić, B., Pjanova, D., Puig, S., Salas-Alanis, J., Schmid, H., Wadt, K.A.W., Newton-Bishop, J.A., Kanetsky, P.A., on behalf of the GenoMEL Study Group Birth cohort-specific trends of sun-related behaviors among individuals from an international consortium of melanoma-prone families (2021) BMC Public Health, 21 (1), art. no. 692,2021https://bmcpublichealth.biomedcentral.com/articles?query=Birth+cohort-specific+trends+of+sun-related+behaviors+among+individuals+from+an+international+consortium+of+melanoma-prone+families&searchType=journalSearch&tab=keyword
Irbe, I., Filipova, I., Skute, M., Zajakina, A., Spunde, K., Juhna, T. Characterization of novel biopolymer blend mycocel from plant cellulose and fungal fibers (2021) Polymers, 13 (7), art. no. 1086.2021https://www.mdpi.com/2073-4360/13/7/1086
Krams, I.A., Krams, R., Jõers, P., Munkevics, M., Trakimas, G., Luoto, S., Eichler, S., Butler, D.M., Merivee, E., Must, A., Rantala, M.J., Contreras-Garduño, J., Krama, T. Developmental speed affects ecological stoichiometry and adult fat reserves in Drosophila melanogaster (2020) 71 (1), pp. 1-202021https://brill.com/view/journals/ab/71/1/article-p1_1.xml
Krigerts, J., Salmina, K., Freivalds, T., Zayakin, P., Rumnieks, F., Inashkina, I., Giuliani, A., Hausmann, M., Erenpreisa, J. Differentiating cancer cells reveal early large-scale genome regulation by pericentric domains (2021) 120 (4), pp. 711-724. Biophysical Journal2021https://www.cell.com/biophysj/fulltext/S0006-3495(21)00032-1
Leja, M., Linē, A. Early detection of gastric cancer beyond endoscopy - new methods (2021) Best Pract Res Clin Gastroenterol, 50-51, art. no. 101731.2021https://pubmed.ncbi.nlm.nih.gov/33975677/
Zrelovs, N., Ustinova, M., Silamikelis, I., Birzniece, L., Megnis, K., Rovite, V., Freimane, L., Silamikele, L., Ansone, L., Pjalkovskis, J., Fridmanis, D., Vilne, B., Priedite, M., Caica, A., Gavars, M., Perminov, D., Storozenko, J., Savicka, O., Dimina, E., Dumpis, U., Klovins, J. First Report on the Latvian SARS-CoV-2 Isolate Genetic Diversity (2021) 8, art. no. 626000, Frontiers in Medicine.2021https://www.frontiersin.org/articles/10.3389/fmed.2021.626000/full
Erenpreisa, J., Krigerts, J., Salmina, K., Gerashchenko, B.I., Freivalds, T., Kurg, R., Winter, R., Krufczik, M., Zayakin, P., Hausmann, M., Giuliani, A. Heterochromatin networks: Topology, dynamics, and function (a working hypothesis)(2021) Cells, 10 (7), art. no. 1582.2021https://pubmed.ncbi.nlm.nih.gov/34201566/
Rostoks, N. Implications of the efsa scientific opinion on site directed nucleases 1 and 2 for risk assessment of genome-edited plants in the eu (2021) 11 (3), art. no. 572, Agronomy2021https://www.mdpi.com/2073-4395/11/3/572
Ruiz-Guzmán, G., Cordero-Molina, S., Krams, I., Contreras-Garduño, J. Interactions between oxidative stress and attractiveness to mates and individual mate choice in the beetle Tenebrio molitor (2021) 127 (2), pp. 109-116. Ethology2021https://onlinelibrary.wiley.com/doi/10.1111/eth.13108
Peculis, R., Niedra, H., Rovite, V. Large scale molecular studies of pituitary neuroendocrine tumors: Novel markers, mechanisms and translational perspectives (2021) Cencers, 13 (6), art. no. 1395, pp. 1-28.2021https://www.mdpi.com/2072-6694/13/6/1395
Altincekic, N., Korn, S.M., Qureshi, N.S., Dujardin, M., Ninot-Pedrosa, M., Abele, R., Abi Saad, M.J., Alfano, C., Almeida, F.C.L., Alshamleh, I., de Amorim, G.C., Anderson, T.K., Anobom, C.D., Anorma, C., Bains, J.K., Bax, A., Blackledge, M., Blechar, J., Böckmann, A., Brigandat, L., Bula, A., Bütikofer, M., Camacho-Zarco, A.R., Carlomagno, T., Caruso, I.P., Ceylan, B., Chaikuad, A., Chu, F., Cole, L., Crosby, M.G., de Jesus, V., Dhamotharan, K., Felli, I.C., Ferner, J., Fleischmann, Y., Fogeron, M.-L., Fourkiotis, N.K., Fuks, C., Fürtig, B., Gallo, A., Gande, S.L., Gerez, J.A., Ghosh, D., Gomes-Neto, F., Gorbatyuk, O., Guseva, S., Hacker, C., Häfner, S., Hao, B., Hargittay, B., Henzler-Wildman, K., Hoch, J.C., Hohmann, K.F., Hutchison, M.T., Jaudzems, K., Jović, K., Kaderli, J., Kalniņš, G., Kaņepe, I., Kirchdoerfer, R.N., Kirkpatrick, J., Knapp, S., Krishnathas, R., Kutz, F., zur Lage, S., Lambertz, R., Lang, A., Laurents, D., Lecoq, L., Linhard, V., Löhr, F., Malki, A., Bessa, L.M., Martin, R.W., Matzel, T., Maurin, D., McNutt, S.W., Mebus-Antunes, N.C., Meier, B.H., Meiser, N., Mompeán, M., Monaca, E., Montserret, R., Mariño Perez, L., Moser, C., Muhle-Goll, C., Neves-Martins, T.C., Ni, X., Norton-Baker, B., Pierattelli, R., Pontoriero, L., Pustovalova, Y., Ohlenschläger, O., Orts, J., Da Poian, A.T., Pyper, D.J., Richter, C., Riek, R., Rienstra, C.M., Robertson, A., Pinheiro, A.S., Sabbatella, R., Salvi, N., Saxena, K., Schulte, L., Schiavina, M., Schwalbe, H., Silber, M., Almeida, M.D.S., Sprague-Piercy, M.A., Spyroulias, G.A., Sreeramulu, S., Tants, J.-N., Tārs, K., Torres, F., Töws, S., Treviño, M.Á., Trucks, S., Tsika, A.C., Varga, K., Wang, Y., Weber, M.E., Weigand, J.E., Wiedemann, C., Wirmer-Bartoschek, J., Wirtz Martin, M.A., Zehnder, J., Hengesbach, M., Schlundt, A. Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications (2021) FRONTIERS IN MOLECULAR BIOSCIENCES, 8, art. no. 653148.2021https://www.frontiersin.org/articles/10.3389/fmolb.2021.653148/full
Rimsa, R., Galvanovskis, A., Plume, J., Rumnieks, F., Grindulis, K., Paidere, G., Erentraute, S., Mozolevskis, G., Abols, A. Lung on a chip development from off-stoichiometry thiol–ene polymer (2021) Micromachines, 12 (5), art. no. 546.2021https://www.mdpi.com/search?q=Lung+on+a+chip+development+from+off-stoichiometry+thiol%E2%80%93ene+polymer&journal=micromachines
Saksis, R., Silamikelis, I., Laksa, P., Megnis, K., Peculis, R., Mandrika, I., Rogoza, O., Petrovska, R., Balcere, I., Konrade, I., Steina, L., Stukens, J., Breiksa, A., Nazarovs, J., Sokolovska, J., Pirags, V., Klovins, J., Rovite, V. Medication for Acromegaly Reduces Expression of MUC16, MACC1 and GRHL2 in Pituitary Neuroendocrine Tumour Tissue (2021) Frontiers in Oncology, 10, art. no. 593760.2021https://www.frontiersin.org/articles/10.3389/fonc.2020.593760/full
Silamiķele, L., Silamiķelis, I., Ustinova, M., Kalniņa, Z., Elbere, I., Petrovska, R., Kalniņa, I., Kloviņš, J. Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes (2021) FRONTIERS IN ENDOCRINOLOGY, 12, art. no. 626359.2021https://www.frontiersin.org/articles/10.3389/fendo.2021.626359/full
Kurlovics, J., Zake, D.M., Zaharenko, L., Berzins, K., Klovins, J., Stalidzans, E. Metformin Transport Rates Between Plasma and Red Blood Cells in Humans (2021) Clinical Pharmacokinetics.2021https://link.springer.com/article/10.1007/s40262-021-01058-2
Ustinova, M., Peculis, R., Rescenko, R., Rovite, V., Zaharenko, L., Elbere, I., Silamikele, L., Konrade, I., Sokolovska, J., Pirags, V., Klovins, J. Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia (2021) BMC Medical Genomics, 14 (1), art. no. 18.2021https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-020-00860-4
Erenpreisa, J., Salmina, K., Anatskaya, O., Cragg, M.S. Paradoxes of cancer: Survival at the brink (2021) Seminars in Cancer Biology.2021https://www.sciencedirect.com/science/article/pii/S1044579X20302698
Zake, D.M., Kurlovics, J., Zaharenko, L., Komasilovs, V., Klovins, J., Stalidzans, E. Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues (2021) PLoS ONE, 16 (4 April), art. no. e0249594.2021https://pubmed.ncbi.nlm.nih.gov/33826656/
Bobiļeva, O., Bobrovs, R., Kaņepe, I., Patetko, L., Kalniņš, G., Šišovs, M., Bula, A.L., Grī Nberga, S., Borodušķis, M.R., Ramata-Stunda, A., Rostoks, N., Jirgensons, A., Tārs, K., Jaudzems, K. Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate (2021) ACS Medicinal Chemistry Letters 12 (7), pp. 1102-1107.2021https://pubs.acs.org/doi/10.1021/acsmedchemlett.1c00140
Petrovskis, I., Lieknina, I., Dislers, A., Jansons, J., Bogans, J., Akopjana, I., Zakova, J., Sominskaya I. Production of the hbc protein from different HBV genotypes in e. coli. use of reassociated HBC vlps for packaging of SS-and DSRNA (2021) MICROORGANISMS, 9 (2), art. no. 283, pp. 1-15.2021https://www.mdpi.com/2076-2607/9/2/283
Zrelovs, N., Kurbatska, V., Rudevica, Z., Leonchiks, A., Fridmanis, D. Sorting out the superbugs: Potential of sortase a inhibitors among other antimicrobial strategies to tackle the problem of antibiotic resistance (2021) ANTIBIOTICS-BASEL, 10 (2), art. no. 164, pp. 1-14.2021https://www.mdpi.com/2079-6382/10/2/164
Moreno-Indias, I., Lahti, L., Nedyalkova, M., Elbere, I., Roshchupkin, G., Adilovic, M., Aydemir, O., Bakir-Gungor, B., Santa Pau, E.C.-D., D’Elia, D., Desai, M.S., Falquet, L., Gundogdu, A., Hron, K., Klammsteiner, T., Lopes, M.B., Marcos-Zambrano, L.J., Marques, C., Mason, M., May, P., Pašić, L., Pio, G., Pongor, S., Promponas, V.J., Przymus, P., Saez-Rodriguez, J., Sampri, A., Shigdel, R., Stres, B., Suharoschi, R., Truu, J., Truică, C.-O., Vilne, B., Vlachakis, D., Yilmaz, E., Zeller, G., Zomer, A.L., Gómez-Cabrero, D., Claesson, M.J., ML4Microbiome Statistical and Machine Learning Techniques in Human Microbiome Studies: Contemporary Challenges and Solutions (2021) FRONTIERS IN MICROBIOLOGY, 12, art. no. 635781.2021https://www.frontiersin.org/articles/10.3389/fmicb.2021.635781/full
Rimkus, A., Gudrā, D., Dubova, L., Fridmanis, D., Alsiņa, I., Muter, O. Stimulation of sewage sludge treatment by carbon sources and bioaugmentation with a sludge-derived microbial consortium (2021) Science of the Total Environment, 783, art. no. 146989.2021https://pubmed.ncbi.nlm.nih.gov/33865123/
Jaudzems, K., Kirsteina, A., Schubeis, T., Casano, G., Ouari, O., Bogans, J., Kazaks, A., Tars, K., Lesage, A., Pintacuda, G.
Structural Analysis of an Antigen Chemically Coupled on Virus-Like Particles in Vaccine Formulation (2021) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 60 (23), pp. 12847-12851.		2021https://pubmed.ncbi.nlm.nih.gov/33750007/
Cernooka, E., Rumnieks, J., Kazaks, A. Structural Characterization of a Single-Stranded DNA-Binding Protein: A Case Study of the ORF6 Protein from Bacteriophage Enc34 (2021) 2281, pp. 343-373. Methods in Molecular Biology.2021https://pubmed.ncbi.nlm.nih.gov/33847971/
Zinkhan, S., Ogrina, A., Balke, I., Reseviča, G., Zeltins, A., de Brot, S., Lipp, C., Chang, X., Zha, L., Vogel, M., Bachmann, M.F., Mohsen, M.O. The impact of size on particle drainage dynamics and antibody response (2021) 331, pp. 296-308. JOURNAL OF CONTROLLED RELEASE.2021https://pubmed.ncbi.nlm.nih.gov/33450322/
Kazarina, A., Petersone‐gordina, E., Kimsis, J., Kuzmicka, J., Zayakin, P., Griškjans, Ž., Gerhards, G., Ranka, R. The postmedieval latvian oral microbiome in the context of modern dental calculus and modern dental plaque microbial profiles (2021) 12 (2), art. no. 309, pp. 1-16. Genes.2021https://pubmed.ncbi.nlm.nih.gov/33671794/
Cesle, E.E., Filimonenko, A., Tars, K., Kalnins, G. Variety of size and form of GRM2 bacterial microcompartment particles (2021) 30 (5), pp. 1035-1043. Protein Science.2021https://pubmed.ncbi.nlm.nih.gov/33763934/
Kivrane, A., Grinberga, S., Sevostjanovs, E., Igumnova, V., Pole, I., Viksna, A., Bandere, D., Krams, A., Cirule, A., Pugovics, O., Ranka, R. LC-MS/MS method for simultaneous quantification of the first-line anti-tuberculosis drugs and six primary metabolites in patient plasma: Implications for therapeutic drug monitoring (2021) 1185, art. no. 122986, Journal of Chromatography B.2021https://www.sciencedirect.com/science/article/pii/S1570023221004670
Brune, K.D., Liekniņa, I., Sutov, G., Morris, A.R., Jovicevic, D., Kalniņš, G., Kazāks, A., Kluga, R., Kastaljana, S., Zajakina, A., Jansons, J., Skrastiņa, D., Spunde, K., Cohen, A.A., Bjorkman, P.J., Morris, H.R., Suna, E., Tārs, K. N-Terminal Modification of Gly-His-Tagged Proteins with Azidogluconolactone (2021) 22 (22), pp. 3199-3207. ChemBioChem.2021https://pubmed.ncbi.nlm.nih.gov/34520613/
Bisenieks, E., Vigante, B., Petrovska, R., Turovska, B., Muhamadejev, R., Soloduns, V., Velena, A., Pajuste, K., Saso, L., Klovins, J., Duburs, G., Mandrika, I. The specificity and broad multitarget properties of ligands for the free fatty acid receptors ffa3/gpr41 and ffa2/gpr43 and the related hydroxycarboxylic acid receptor hca2/gpr109a (2021) 14 (10), art. no. 987, Pharmaceuticals.2021https://www.mdpi.com/1424-8247/14/10/987
Zablocka, T., Nikolajeva, A., Kreismane, M., Pjanova, D., Isajevs, S. Addressing the importance of melanoma tumor-infiltrating lymphocytes in disease progression and clinicopathological characteristics (2021) 15 (6), art. no. 255, Molecular and Clinical Oncology.2021https://www.spandidos-publications.com/10.3892/mco.2021.2417
Freimane, L., Barkane, L., Igumnova, V., Kivrane, A., Zole, E., Ranka, R. Telomere length and mitochondrial DNA copy number in multidrug-resistant tuberculosis
(2021) 131, art. no. 102144,Tuberculosis.
2021https://www.sciencedirect.com/science/article/pii/S1472979221000949
Kazarina, A., Kimsis, J., Petersone-Gordina, E., Zayakin, P., Poksane, A., Gerhards, G., Ranka, R. Exploring DNA preservation and taxonomic diversity in postmedieval human tooth samples in Latvia (2021) 40, art. no. 103213, Journal of Archaeological Science.2021https://www.sciencedirect.com/science/article/pii/S2352409X21004259
Mohsen, M.O., Rothen, D., Balke, I., Martina, B., Zeltina, V., Inchakalody, V., Gharailoo, Z., Nasrallah, G., Dermime, S., Tars, K., Vogel, M., Zeltins, A., Bachmann, M.F. Neutralization of MERS coronavirus through a scalable nanoparticle vaccine (2021) 6 (1), art. no. 107,npj Vaccines.2021https://www.nature.com/articles/s41541-021-00365-w
Kivrane, A., Namina, A., Seleznova, M., Akopjana, S., Capligina, V., Ranka, R. Development of a real-time PCR method for rapid diagnosis of canine babesiosis and anaplasmosis (2021) 14 (1), art. no. 266, Parasites & Vectors.2021https://pubmed.ncbi.nlm.nih.gov/34016173/
Vogt, A.-C.S., Roesti, E.S., Mohsen, M.O., Leonchiks, A., Vogel, M., Bachmann, M.F. Anti-iapp monoclonal antibody improves clinical symptoms in a mouse model of type 2 diabetes (2021) 9 (11), art. no. 1316,Vaccines.2021https://www.mdpi.com/2076-393X/9/11/1316
Chang, X., Zeltins, A., Mohsen, M.O., Gharailoo, Z., Zha, L., Liu, X., Walton, S., Vogel, M., Bachmann, M.F. A novel double mosaic virus-like particle-based vaccine against SARS-CoV-2 incorporates both receptor binding motif (RBM) and fusion domain (2021) 9 (11), art. no. 1287, Vaccines.2021https://www.mdpi.com/2076-393X/9/11/1287
Trofimova, O., Korotkaja, K., Skrastina, D., Jansons, J., Spunde, K., Isaguliants, M., Zajakina, A. Alphavirus‐driven interferon gamma (IFNg) expression inhibits tumor growth in orthotopic 4T1 breast cancer model (2021) 9 (11), art. no. 1247, Vaccines2021https://www.mdpi.com/2076-393X/9/11/1247
Krupovic, M., Turner, D., Morozova, V., Dyall-Smith, M., Oksanen, H.M., Edwards, R., Dutilh, B.E., Lehman, S.M., Reyes, A., Baquero, D.P., Sullivan, M.B., Uchiyama, J., Nakavuma, J., Barylski, J., Young, M.J., Du, S., Alfenas-Zerbini, P., Kushkina, A., Kropinski, A.M., Kurtböke, I., Brister, J.R., Lood, C., Sarkar, B.L., Yigang, T., Liu, Y., Huang, L., Wittmann, J., Chanishvili, N., van Zyl, L.J., Rumnieks, J., Mochizuki, T., Jalasvuori, M., Aziz, R.K., Łobocka, M., Stedman, K.M., Shkoporov, A.N., Gillis, A., Peng, X., Enault, F., Knezevic, P., Lavigne, R., Rhee, S.-K., Cvirkaite-Krupovic, V., Moraru, C., Moreno Switt, A.I., Poranen, M.M., Millard, A., Prangishvili, D., Adriaenssens, E.M. Bacterial Viruses Subcommittee and Archaeal Viruses Subcommittee of the ICTV: update of taxonomy changes in 2021 (2021) 166 (11), pp. 3239-3244. Archives of Virology.2021https://pubmed.ncbi.nlm.nih.gov/34417873/
Hauserman, J.G., Stavusis, J., Joca, H.C., Robinett, J.C., Hanft, L., Vandermeulen, J., Zhao, R., Stains, J.P., Konstantopoulos, K., McDonald, K.S., Ward, C., Kontrogianni-Konstantopoulos, A. Sarcomeric deficits underlie MYBPC1 associated myopathy with myogenic tremor (2021) 6 (19), art. no. e147612, JCI insight.2021https://pubmed.ncbi.nlm.nih.gov/34437302/
Ghini, V., Abuja, P.M., Polasek, O., Kozera, L., Laiho, P., Anton, G., Zins, M., Klovins, J., Metspalu, A., Wichmann, H.-E., Gieger, C., Luchinat, C., Zatloukal, K., Turano, P. Metabolomic Fingerprints in Large Population Cohorts: Impact of Preanalytical Heterogeneity (2021) 67 (8), pp. 1153-1155, Clinical Chemistry.2021https://pubmed.ncbi.nlm.nih.gov/34223627/
Zrelovs, N., Dislers, A., Kazaks, A. Genome characterization of nocturne116, novel lactococcus lactis‐infecting phage isolated from moth (2021) 9 (7), art. no. 1540, Microorganisms.2021https://www.mdpi.com/2076-2607/9/7/1540
Kivrane, A., Igumnova, V., Kimsis, J., Freimane, L., Sadovska, D., Viksna, A., Pole, I., Ranka, R. Implementation of a next-generation sequencing-based targeted approach for full-length CYP3A4 gene sequencing (2021) 22 (9), pp. 519-527, Pharmacogenomics.2021https://pubmed.ncbi.nlm.nih.gov/34003019/
Isaguliants, M., Krotova, O., Petkov, S., Jansons, J., Bayurova, E., Mezale, D., Fridrihsone, I., Kilpelainen, A., Podschwadt, P., Agapkina, Y., Smirnova, O., Kostic, L., Saleem, M., Latyshev, O., Eliseeva, O., Malkova, A., Gorodnicheva, T., Wahren, B., Gordeychuk, I., Starodubova, E., Latanova, A. Cellular immune response induced by dna immunization of mice with drug resistant integrases of hiv-1 clade a offers partial protection against growth and metastatic activity of integrase-expressing adenocarcinoma cells (2021) 9 (6), art. no. 1219, Microorganisms.2021https://www.mdpi.com/2076-2607/9/6/1219
Jansons, J., Skrastina, D., Kurlanda, A., Petkov, S., Avdoshina, D., Kuzmenko, Y., Krotova, O., Trofimova, O., Gordeychuk, I., Sominskaya, I., Isaguliants, M.
Reciprocal inhibition of immunogenic performance in mice of two potent dna immunogens targeting hcv-related liver cancer (2021) 9 (5), art. no. 1073, Microorganisms.		2021https://www.mdpi.com/2076-2607/9/5/1073
Liu, X., Chang, X., Rothen, D., Derveni, M., Krenger, P., Roongta, S., Wright, E., Vogel, M., Tars, K., Mohsen, M.O., Bachmann, M.F. AP205 VLPs based on dimerized capsid proteins accommodate RBM domain of SARS-CoV-2 and serve as an attractive vaccine candidate
(2021) 9 (4), art. no. 403, Vaccines.		2021https://www.mdpi.com/2076-393X/9/4/403
Ramirez-Garrastacho, M., Berge, V., Linē, A., Llorente, A. Potential of miRNAs in urinary extracellular vesicles for management of active surveillance in prostate cancer patients (2021) British Journal of Cancer.2021https://www.nature.com/articles/s41416-021-01598-1
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Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
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Sokolovska, J., Stefanovics, J., Gersone, G., Pahirko, L., Valeinis, J., Kalva-Vaivode, S., Rovite, V., Blumfelds, L., Pirags, V., Tretjakovs, P. Angiopoietin 2 and Neuropeptide y are Associated with Diabetic Kidney Disease in Type 1 Diabetes Mellitus (2020) Experimental and Clinical Endocrinology and Diabetes, 128 (10), pp. 654-662.2020https://pubmed.ncbi.nlm.nih.gov/31958847/
Pjanova, D., Ruklisa, D., Kregere, E., Azarjana, K., Ozola, A., Cema, I. Features associated with melanoma metastasis in Latvia (2020) Oncology Letters, 20 (4), art. no. 11978.2020https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448568/
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Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants (2020) Genetics in Medicine, 22 (10), pp. 1653-1666.		2020https://pubmed.ncbi.nlm.nih.gov/32665703/
García-Calzón, S., Perfilyev, A., Martinell, M., Ustinova, M., Kalamajski, S., Franks, P.W., Bacos, K., Elbere, I., Pihlajamäki, J., Volkov, P., Vaag, A., Groop, L., Maziarz, M., Klovins, J., Ahlqvist, E., Ling, C. Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes (2020) Science Translational Medicine, 12 (561), art. no. eaaz1803.2020https://pubmed.ncbi.nlm.nih.gov/32938793/
Rumnieks, J., Lieknina, I., Kalninš, G., Sišovs, M., Akopjana, I., Bogans, J., Tars, K. Three-dimensional structure of 22 uncultured ssrna bacteriophages: Flexibility of the coat protein fold and variations in particle shapes (2020) Science Advances, 6 (36), art. no. eabc0023.2020https://pubmed.ncbi.nlm.nih.gov/32917600/
Bojko, A., Staniak, K., Czarnecka-Herok, J., Sunderland, P., Dudkowska, M., Śliwińska, M.A., Salmina, K., Sikora, E. Improved autophagic flux in escapers from doxorubicin-induced senescence/polyploidy of breast cancer cells (2020) International Journal of Molecular Sciences, 21 (17), art. no. 6084, pp. 1-22.2020https://pubmed.ncbi.nlm.nih.gov/32846959/
Vedmedovska, N., Bokucava, D., Kivite-Urtane, A., Rovite, V., Zake-Nikitina, L., Klovins, J., Fodina, V., Donders, G.G.G. The correlation between abnormal uterine artery flow in the first trimester and genetic thrombophilic alteration: a prospective case-controlled pilot study (2020) Diagnostics, 10 (9), art. no. 654.2020https://pubmed.ncbi.nlm.nih.gov/32878173/
Liekniņa, I., Černova, D., Rūmnieks, J., Tārs, K. Novel ssRNA phage VLP platform for displaying foreign epitopes by genetic fusion (2020) Vaccine, 38 (38), pp. 6019-6026.2020https://pubmed.ncbi.nlm.nih.gov/32713683/
Martín-Gracia, B., Martín-Barreiro, A., Cuestas-Ayllón, C., Grazú, V., Line, A., Llorente, A., De La Fuente, J.M., Moros, M. Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies (2020) Journal of Materials Chemistry B, 8 (31), pp. 6710-6738.2020https://pubmed.ncbi.nlm.nih.gov/32627783/
Ustinova, M., Ansone, L., Silamikelis, I., Rovite, V., Elbere, I., Silamikele, L., Kalnina, I., Fridmanis, D., Sokolovska, J., Konrade, I., Pirags, V., Klovins, J. Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response (2020) PLoS ONE, 15 (8 August), art. no. e0237400.2020https://pubmed.ncbi.nlm.nih.gov/32780768/
Mezinska, S., Kaleja, J., Mileiko, I., Santare, D., Rovite, V., Tzivian, L. Public awareness of and attitudes towards research biobanks in Latvia (2020) BMC Medical Ethics, 21 (1), art. no. 65.2020https://pubmed.ncbi.nlm.nih.gov/32736554/
Capligina, V., Seleznova, M., Akopjana, S., Freimane, L., Lazovska, M., Krumins, R., Kivrane, A., Namina, A., Aleinikova, D., Kimsis, J., Kazarina, A., Igumnova, V., Bormane, A., Ranka, R. Large-scale countrywide screening for tick-borne pathogens in field-collected ticks in Latvia during 2017-2019 (2020) Parasites and Vectors, 13 (1), art. no. 351.2020https://pubmed.ncbi.nlm.nih.gov/32665019/
Feng, H., Gusev, A., Pasaniuc, B., Wu, L., Long, J., Abu-full, Z., Aittomäki, K., Andrulis, I.L., Anton-Culver, H., Antoniou, A.C., Arason, A., Arndt, V., Aronson, K.J., Arun, B.K., Asseryanis, E., Auer, P.L., Azzollini, J., Balmaña, J., Barkardottir, R.B., Barnes, D.R., Barrowdale, D., Beckmann, M.W., Behrens, S., Benitez, J., Bermisheva, M., Białkowska, K., Blanco, A., Blomqvist, C., Boeckx, B., Bogdanova, N.V., Bojesen, S.E., Bolla, M.K., Bonanni, B., Borg, A., Brauch, H., Brenner, H., Briceno, I., Broeks, A., Brüning, T., Burwinkel, B., Cai, Q., Caldés, T., Caligo, M.A., Campbell, I., Canisius, S., Campa, D., Carter, B.D., Carter, J., Castelao, J.E., Chang-Claude, J., Chanock, S.J., Christiansen, H., Chung, W.K., Claes, K.B.M., Clarke, C.L., Couch, F.J., Cox, A., Cross, S.S., Cybulski, C., Czene, K., Daly, M.B., de la Hoya, M., De Leeneer, K., Dennis, J., Devilee, P., Diez, O., Domchek, S.M., Dörk, T., dos-Santos-Silva, I., Dunning, A.M., Dwek, M., Eccles, D.M., Ejlertsen, B., Ellberg, C., Engel, C., Eriksson, M., Fasching, P.A., Fletcher, O., Flyger, H., Fostira, F., Friedman, E., Fritschi, L., Frost, D., Gabrielson, M., Ganz, P.A., Gapstur, S.M., Garber, J., García-Closas, M., García-Sáenz, J.A., Gaudet, M.M., Giles, G.G., Glendon, G., Godwin, A.K., Goldberg, M.S., Goldgar, D.E., González-Neira, A., Greene, M.H., Gronwald, J., Guénel, P., Haiman, C.A., Hall, P., Hamann, U., Hake, C., He, W., Heyworth, J., Hogervorst, F.B.L., Hollestelle, A., Hooning, M.J., Hoover, R.N., Hopper, J.L., Huang, G., Hulick, P.J., Humphreys, K., Imyanitov, E.N., Isaacs, C., Jakimovska, M., Jakubowska, A., James, P., Janavicius, R., Jankowitz, R.C., John, E.M., Johnson, N., Joseph, V., Jung, A., Karlan, B.Y., Khusnutdinova, E., Kiiski, J.I., Konstantopoulou, I., Kristensen, V.N., Laitman, Y., Lambrechts, D., Lazaro, C., Leroux, D., Leslie, G., Lester, J., Lesueur, F., Lindor, N., Lindström, S., Lo, W.-Y., Loud, J.T., Lubiński, J., Makalic, E., Mannermaa, A., Manoochehri, M., Manoukian, S., Margolin, S., Martens, J.W.M., Martinez, M.E., Matricardi, L., Maurer, T., Mavroudis, D., McGuffog, L., Meindl, A., Menon, U., Michailidou, K., Kapoor, P.M., Miller, A., Montagna, M., Moreno, F., Moserle, L., Mulligan, A.M., Muranen, T.A., Nathanson, K.L., Neuhausen, S.L., Nevanlinna, H., Nevelsteen, I., Nielsen, F.C., Nikitina-Zake, L., Offit, K., Olah, E., Olopade, O.I., Olsson, H., Osorio, A., Papp, J., Park-Simon, T.-W., Parsons, M.T., Pedersen, I.S., Peixoto, A., Peterlongo, P., Peto, J., Pharoah, P.D.P., Phillips, K.-A., Plaseska-Karanfilska, D., Poppe, B., Pradhan, N., Prajzendanc, K., Presneau, N., Punie, K., Pylkäs, K., Radice, P., Rantala, J., Rashid, M.U., Rennert, G., Risch, H.A., Robson, M., Romero, A., Saloustros, E., Sandler, D.P., Santos, C., Sawyer, E.J., Schmidt, M.K., Schmidt, D.F., Schmutzler, R.K., Schoemaker, M.J., Scott, R.J., Sharma, P., Shu, X.-O., Simard, J., Singer, C.F., Skytte, A.-B., Soucy, P., Southey, M.C., Spinelli, J.J., Spurdle, A.B., Stone, J., Swerdlow, A.J., Tapper, W.J., Taylor, J.A., Teixeira, M.R., Terry, M.B., Teulé, A., Thomassen, M., Thöne, K., Thull, D.L., Tischkowitz, M., Toland, A.E., Tollenaar, R.A.E.M., Torres, D., Truong, T., Tung, N., Vachon, C.M., van Asperen, C.J., van den Ouweland, A.M.W., van Rensburg, E.J., Vega, A., Viel, A., Vieiro-Balo, P., Wang, Q., Wappenschmidt, B., Weinberg, C.R., Weitzel, J.N., Wendt, C., Winqvist, R., Yang, X.R., Yannoukakos, D., Ziogas, A., Milne, R.L., Easton, D.F., Chenevix-Trench, G., Zheng, W., Kraft, P., Jiang, X., GEMO Study Collaborators, EMBRACE Collaborators, GC-HBOC study Collaborators, ABCTB Investigators, HEBON Investigators, BCFR Investigators, OCGN Investigators
Transcriptome-wide association study of breast cancer risk by estrogen-receptor status
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Malniece, I., Grasmane, A., Inashkina, I., Stavusis, J., Kreile, M., Miklasevics, E., Gailite, L. The fetal phenotype of noonan syndrome caused by severe, cancer-related PTPN11 variants (2020) American Journal of Case Reports, 21, art. no. e922468, pp. e922468-1-e922468-6.2020https://pubmed.ncbi.nlm.nih.gov/32794475/
Zalizko, P., Stefanovics, J., Sokolovska, J., Paramonova, N., Klavina, E., Erts, R., Rovite, V., Klovins, J., Pukitis, A. Thiopurine S-methyltransferase genetic polymorphisms in adult patients with inflammatory bowel diseases in the Latvian population (2020) Therapeutic Advances in Gastroenterology, 13.2020https://pubmed.ncbi.nlm.nih.gov/32704308/
Fridmanis, J., Bobrovs, R., Brangulis, K., Tārs, K., Jaudzems, K. Structural and functional analysis of bba03, borrelia burgdorferi competitive advantage promoting outer surface lipoprotein (2020) Pathogens, 9 (10), art. no. 826, pp. 1-13.2020https://pubmed.ncbi.nlm.nih.gov/33050189/
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Jansons J, Sominskaya I, Petrakova N, Starodubova ES, Smirnova OA, Alekseeva E, Bruvere R, Eliseeva O, Skrastina D, Kashuba E, Mihailova M, Kochetkov SN, Ivanov AV, Isaguliants MG. The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response. Cells. 2019 Feb 28;8(3). pii: E208.2019https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468923/
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Ekaterina Bayurova, Juris Jansons, Dace Skrastina, Olga Smirnova, Dzeina Mezale, Anastasia Kostyusheva, Dmitry Kostyushev, Stefan Petkov, Philip Podschwadt, Vladimir Valuev-Elliston, Sviataslau Sasinovich, Sergey Korolev, Per Warholm, Anastasia Latanova, Elizaveta Starodubova, Amir Tukhvatulin, Oleg Latyshev, Renat Selimov, Pavel Metalnikov, Alexander Komarov, Olga Ivanova, Tatiana Gorodnicheva, Sergey Kochetkov, Marina Gottikh, Ilze Strumfa, Alexander Ivanov, Ilya Gordeychuk, and Maria Isaguliants. HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist. Oxidative Medicine and Cellular Longevity Volume 2019, Article ID 6016278.2019https://www.hindawi.com/journals/omcl/2019/6016278/
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(2019) American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 180 (3), pp. 223-231.		2019https://pubmed.ncbi.nlm.nih.gov/30801977/
Kryshtafovych, A., Albrecht, R., Baslé, A., Bule, P., Caputo, A.T., Carvalho, A.L., Chao, K.L., Diskin, R., Fidelis, K., Fontes, C.M.G.A., Fredslund, F., Gilbert, H.J., Goulding, C.W., Hartmann, M.D., Hayes, C.S., Herzberg, O., Hill, J.C., Joachimiak, A., Kohring, G.-W., Koning, R.I., Lo Leggio, L., Mangiagalli, M., Michalska, K., Moult, J., Najmudin, S., Nardini, M., Nardone, V., Ndeh, D., Nguyen, T.-H., Pintacuda, G., Postel, S., van Raaij, M.J., Roversi, P., Shimon, A., Singh, A.K., Sundberg, E.J., Tars, K., Zitzmann, N., Schwede, T. Target highlights from the first post-PSI CASP experiment (CASP12, May–August 2016) (2018) Proteins: Structure, Function and Bioinformatics, 86, pp. 27-50.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=28960539
Balke, I., Reseviča, G., Zeltins, A. Isolation and characterization of two distinct types of unmodified spherical plant sobemovirus-like particles for diagnostic and technical uses (2018) Methods in Molecular Biology, 1776, pp. 19-34.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29869232
Rūmnieks, J., Tārs, K. Protein-RNA interactions in the single-stranded RNA bacteriophages (2018) Subcellular Biochemistry, 88, pp. 281-303.2018https://www.ncbi.nlm.nih.gov/pubmed/29900502
Zeltins, A. Protein complexes and virus-like particle technology (2018) Subcellular Biochemistry, 88, pp. 379-405.2018https://www.ncbi.nlm.nih.gov/pubmed/29900505
Kalnins G, Sevostjanovs E, Hartmane D, Grinberga S, Tars K. CntA oxygenase substrate profile comparison and oxygen dependency of TMA production in Providencia rettgeri. (2017) Journal of Basic Microbiology, 58 (1), pp. 52-59.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29110324
Jaudzems, K., Bertarello, A., Chaudhari, S.R., Pica, A., Cala-De Paepe, D., Barbet-Massin, E., Pell, A.J., Akopjana, I., Kotelovica, S., Gajan, D., Ouari, O., Tars, K., Pintacuda, G., Lesage, A. Dynamic Nuclear Polarization-Enhanced Biomolecular NMR Spectroscopy at High Magnetic Field with Fast Magic-Angle Spinning (2018) Angewandte Chemie - International Edition, 57 (25), pp. 7458-7462.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29566299
Adriaenssens, E.M., Wittmann, J., Kuhn, J.H., Turner, D., Sullivan, M.B., Dutilh, B.E., Jang, H.B., van Zyl, L.J., Klumpp, J., Lobocka, M., Moreno Switt, A.I., Rumnieks, J., Edwards, R.A., Uchiyama, J., Alfenas-Zerbini, P., Petty, N.K., Kropinski, A.M., Barylski, J., Gillis, A., Clokie, M.R.C., Prangishvili, D., Lavigne, R., Aziz, R.K., Duffy, S., Krupovic, M., Poranen, M.M., Knezevic, P., Enault, F., Tong, Y., Oksanen, H.M., Rodney Brister, J. Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee (2018) Archives of Virology, pp. 1-5. [Article in Press.]2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29356990
Zole E, Ranka R. Mitochondria, its DNA and telomeres in ageing and human population. (2018) Biogerontology, Feb 28. doi: 10.1007/s10522 018-9748-6. [Epub ahead of print] Review.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29488130
Kuznecovs, J., Vorona, M., Domraceva, I., Kanepe-Lapsa, I., Petrova, M., Liepins, E., Belyakov, S., Leonchiks, A., Veinberg, G. Synthesis and study of new 5-substituted 1-acetyl-4-phenyl-3-pyrrolin-2-ones as potential antitumor agents (2018) Chemistry of Heterocyclic Compounds, 54 (5), pp. 514-519.2018https://link.springer.com/article/10.1007/s10593-018-2298-7
Balke, I., Zeltins, A. Use of plant viruses and virus-like particles for the creation of novel vaccines (2018) Advanced Drug Delivery Reviews, . Article in Press.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30172923
Ni, G., Moser, G., Ripke, S., Neale, … Klovins, J., … Wray, N.R., Lee, S.H., Psychosis Endophenotypes International Consortium, Wellcome Trust Case-Control Consortium. Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood (2018) American Journal of Human Genetics, 102 (6), pp. 1185-1194.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29754766
Sadovska L, Zandberga E, Sagini K, Jēkabsons K, Riekstiņa U, Kalniņa Z, Llorente A, Linē A. A novel 3D heterotypic spheroid model for studying extracellular vesicle-mediated tumour and immune cell communication. Biochem Biophys Res Commun. (2018) Jan 8;495(2):1930-1935. doi: 10.1016/j.bbrc.2017.12.072.2018https://www.ncbi.nlm.nih.gov/pubmed/29248729
Gul, H.I., Yamali, C., Sakagami, H., Angeli, A., Leitans, J., Kazaks, A., Tars, K., Ozgun, D.O., Supuran, C.T. New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors (2018) Bioorganic Chemistry, 77, pp. 411-419.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29427856
Buğday, N., Küçükbay, F.Z., Küçükbay, H., Bua, S., Bartolucci, G., Leitans, J., Kazaks, A., Tars, K., Supuran, C.T. Synthesis of novel dipeptide sulfonamide conjugates with effective carbonic anhydrase I, II, IX, and XII inhibitory properties (2018) Bioorganic Chemistry, 81, pp. 311-318.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30176570
Rasina, D., Stakanovs, G., Borysov, O.V., Pantelejevs, T., Bobrovs, R., Kanepe-Lapsa, I., Tars, K., Jaudzems, K., Jirgensons, A. 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity (2018) Bioorganic and Medicinal Chemistry, . Article in Press.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29636223
Ruderfer, D.M., Ripke, S., McQuillin, A., … Klovins, J., … Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes (2018) Cell, 173 (7), pp. 1705-1715.e16.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29906448
Bachmann, M.F., Zeltins, A., Kalnins, G., Balke, I., Fischer, N., Rostaher, A., Tars, K., Favrot, C. Vaccination against IL-31 for the treatment of atopic dermatitis in dogs (2018) Journal of Allergy and Clinical Immunology, 142 (1), pp. 279-281.e1.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29627081
Fettelschoss-Gabriel, A., Fettelschoss, V., Thoms, F., Giese, C., Daniel, M., Olomski, F., Kamarachev, J., Birkmann, K., Bühler, M., Kummer, M., Zeltins, A., Marti, E., Kündig, T.M., Bachmann, M.F. Treating insect-bite hypersensitivity in horses with active vaccination against IL-5 (2018) The Journal of allergy and clinical immunology, 142 (4), pp. 1194-1205.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29627082
Osseman Q, Gallucci L, Au S, Cazenave C, Berdance E, Blondot ML, Cassany A,Bégu D, Ragues J, Aknin C, Sominskaya I, Dishlers A, Rabe B, Anderson F, Panté N, Kann M. The chaperone dynein LL1 mediates cytoplasmic transport of empty and mature hepatitis B virus capsids. (2017) J Hepatol., Nov 4. [Epub ahead of print]2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29113909
Ozola, A., Ruklisa, D., Pjanova, D. Association of the 16q24.3 region gene variants rs1805007 and rs4785763 with heightened risk of melanoma in Latvian population (2018) Meta Gene, 18, pp. 87-92.2018https://www.sciencedirect.com/science/article/pii/S2214540018301610
Latanova, A.A., Petkov, S., Kilpelainen, A., Jansons, J., Latyshev, O.E., Kuzmenko, Y.V., Hinkula, J., Abakumov, M.A., Valuev-Elliston, V.T., Gomelsky, M., Karpov, V.L., Chiodi, F., Wahren, B., Logunov, D.Y., Starodubova, E.S., Isaguliants, M.G. Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-Type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity (2018) Scientific Reports, 8 (1), art. no. 8078.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29799015
Ni, G., Gratten, J., Wray, N.R., ... Klovins, J., ... Nikitina-Zake, L., ... M.J., Sullivan, P.F., O'donovan, M.C. Age at first birth in women is genetically associated with increased risk of schizophrenia (2018) Scientific Reports, 8 (1), art. no. 10168.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29977057
Rachakonda, S., Srinivas, N., Mahmoudpour, S.H., Garcia-Casado, Z., Requena, C., Traves, V., Soriano, V., Cardelli, M., Pajnova, D., Molven, A., Gruis, N., Nagore, E., Kumar, R. Telomere length and survival in primary cutaneous melanoma patients (2018) Scientific Reports, 8 (1), art. no. 10947.2018https://www.ncbi.nlm.nih.gov/pubmed/30026606
Brangulis, K., Akopjana, I., Petrovskis, I., Kazaks, A., Kraiczy, P., Tars, K. Crystal structure of the membrane attack complex assembly inhibitor BGA71 from the Lyme disease agent Borrelia bavariensis (2018) Scientific Reports, 8 (1), art. no. 11286.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30050126
Grube, M., Shvirksts, K., Krafft, C., Kokorevicha, S., Zandberga, E., Abols, A., Line, A., Kalnenieks, U. Miniature diamond-anvil cells for FTIR-microspectroscopy of small quantities of biosamples (2018) Analyst, 143 (15), pp. 3595-3599.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29961798
Baryshev M, Inashkina I, Salmina K, Huna A, Jackson TR, Erenpreisa J. DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells. (2018) Cell Cycle, Mar 19:1-5. doi: 10.1080/15384101.2018.1426412. [Epub ahead of print]2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29372665
Erenpreisa J, Krigerts J, Salmina K, Selga T, Sorokins H, Freivalds T.
Differential staining of peripheral nuclear chromatin with Acridine orange implies an A-form epichromatin conformation of the DNA (2018) Nucleus. Jan 1;9(1):171-181. doi: 10.1080/19491034.2018.1431081.		2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29363398
Théry, C., Witwer, K.W., Aikawa, E., ... Linē, A., ...., Zimmermann, P., Zivkovic, A.M., Zocco, D., Zuba-Surma, E.K. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines (2018) Journal of Extracellular Vesicles, 8 (1), art. no. 1535750.2018https://www.tandfonline.com/doi/abs/10.1080/20013078.2018.1535750
Delaunay, T., Violland, M., Boisgerault, N., Dutoit, S., Vignard, V., Münz, C., Gannage, M., Dréno, B., Vaivode, K., Pjanova, D., Labarrière, N., Wang, Y., Chiocca, E.A., Boeuf, F.L., Bell, J.C., Erbs, P., Tangy, F., Grégoire, M., Fonteneau, J.-F. Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells (2018) OncoImmunology, 7 (3), art. no. e1407897.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29399408
Pelnena, D., Burnyte, B., Jankevics, E., Lace, B., Dagyte, E., Grigalioniene, K., Utkus, A., Krumina, Z., Rozentale, J., Adomaitiene, I., Stavusis, J., Pliss, L., Inashkina, I. Complete mtDNA sequencing reveals mutations m.9185T>C and m.13513G>A in three patients with Leigh syndrome (2017) Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis, pp. 1-6.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29228836
Zake, T., Skuja, S., Kalere, I., Konrade, I., Groma, V. Heterogeneity of tissue IL-17 and tight junction proteins expression demonstrated in patients with autoimmune thyroid diseases (2018) Medicine (United States), 97 (25), art. no. E11211.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29924048
Mishnev, A., Bisenieks, E., Mandrika, I., Petrovska, R., Kalme, Z., Bruvere, I., Duburs, G. Crystal structure and metabolic activity of 4-(thien-2-yl)-2 methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid ethoxycarbonylphenyl-methylester (2018) Acta Crystallographica Section E: Crystallographic Communications, 74, pp. 1577-1579.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30443384
Valassi, E., Feelders, R., ... Pirags, V., ... Zosin, I., the ERCUSYN Study Group. Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN (2018) Clinical Endocrinology, 88 (6), pp. 787-798.2018https://www.ncbi.nlm.nih.gov/pubmed/29574994
Sviklāne, L., Olmane, E., Dzērve, Z., Kupčs, K., Pīrāgs, V., Sokolovska, J. Fatty liver index and hepatic steatosis index for prediction of non-alcoholic fatty liver disease in type 1 diabetes (2018) Journal of Gastroenterology and Hepatology (Australia), 33 (1), pp. 270-276.2018https://www.ncbi.nlm.nih.gov/pubmed/28464337
Anttila, V., Bulik-Sullivan, ... Klovins, J., … Corvin, A., Neale, B.M. Analysis of shared heritability in common disorders of the brain (2018) Science, 360 (6395), art. no. 8757.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29930110
Nazarkina, Z.K., Zajakina, A., Laktionov, P.P. Maturation and Antigen Loading Protocols Influence Activity of Anticancer Dendritic Cells (2018) Molecular Biology, 52 (2), pp. 222-231.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29695694
Gudra, D., Shoaie, S., Fridmanis, D., Klovins, J., Wefer, H., Silamikelis, I., Peculis, R., Kalnina, I., Elbere, I., Radovica-Spalvina, I., Hultcrantz, R., Skenders, G., Leja, M., Engstrand, L. A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies (2018) Gut, . Article in Press.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30242040
Silina, K., Soltermann, A., Attar, F.M., Casanova, R., Uckeley, Z.M., Thut, H., Wandres, M., Isajevs, S., Cheng, P., Curioni-Fontecedro, A., Foukas, P., Levesque, M.P., Moch, H., Line, A., Van Den Broek, M. Germinal centers determine the prognostic relevance of tertiary lymphoid structures and are impaired by corticosteroids in lung squamous cell carcinoma (2018) Cancer Research, 78 (5), pp. 1308-13202018https://www.ncbi.nlm.nih.gov/pubmed/?term=29279354
Lu, Y., Beeghly-Fadiel, A., ...Nikitina-Zake, L., ..., Zheng, W., Long, J. A transcriptome-wide association study among 97,898 women to identify candidate susceptibility genes for epithelial ovarian cancer risk (2018) Cancer Research, 78 (18), pp. 5419-5430.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30054336
Speck, T., Heidbuechel, J.P.W., Veinalde, R., Jaeger, D., Von Kalle, C., Ball, C.R., Ungerechts, G., Engeland, C.E. Targeted bite expression by an oncolytic vector augments therapeutic efficacy against solid tumors (2018) Clinical Cancer Research, 24 (9), pp. 2128-2137.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29437789
LeBlanc, M., Zuber, V., Thompson, W.K., Andreassen, O.A., … Klovins, J., … McIntosh, A., Breuer, R., Steffens, M., Treutlein, J. A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework (2018) BMC Genomics, 19 (1), art. no. 494.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29940862
Popěna, I., Abols, A., Saulite, L., Pleiko, K., Zandberga, E., Jěkabsons, K., Endzeliņš, E., Llorente, A., Lině, A., Riekstiņa, U. Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages (2018) Cell Communication and Signaling, 16 (1), art. no. 17.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29690889
Tambets, K., Yunusbayev, B., Hudjashov, G., Ilumäe, A.-M., Rootsi, S., Honkola, T., Vesakoski, O., Atkinson, Q., Skoglund, P., Kushniarevich, A., Litvinov, S., Reidla, M., Metspalu, E., Saag, L., Rantanen, T., Karmin, M., Parik, J., Zhadanov, S.I., Gubina, M., Damba, L.D., Bermisheva, M., Reisberg, T., Dibirova, K., Evseeva, I., Nelis, M., Klovins, J., Metspalu, A., Esko, T., Balanovsky, O., Balanovska, E., Khusnutdinova, E.K., Osipova, L.P., Voevoda, M., Villems, R., Kivisild, T., Metspalu, M. Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations (2018) Genome Biology, 19 (1), art. no. 139.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30241495
Elbere I, Silamikelis I, Ustinova M, Kalnina I, Zaharenko L, Peculis R, Konrade I, Ciuculete DM, Zhukovsky C, Gudra D, Radovica-Spalvina I, Fridmanis D, Pirags V, Schiöth HB, Klovins J. Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals. (2018) Clinical Epigenetics, 10 (1), art. no. 156.2018https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-018-0593-x
Mandrika, I., Tilgase, A., Petrovska, R., Klovins, J. Hydroxycarboxylic acid receptor ligands modulate proinflammatory cytokine expression in human macrophages and adipocytes without affecting adipose differentiation (2018) Biological and Pharmaceutical Bulletin, 41 (10), pp. 1574-1580.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30270326
Elbere, I., Kalnina, I., Silamikelis, I., Konrade, I., Zaharenko, L., Sekace, K., Radovica-Spalvina, I., Fridmanis, D., Gudra, D., Pirags, V., Klovins, J. Association of metformin administration with gut microbiome dysbiosis in healthy volunteers (2018) PLoS ONE, 13 (9), art. no. e0204317.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30261008
Lu, I.-N., Kirsteina, A., Farinelle, S., Willieme, S., Tars, K., Muller, C.P., Kazaks, A. Structure and applications of novel influenza HA tri-stalk protein for evaluation of HA stemspecific immunity (2018) PLoS ONE, 13 (9), art. no. E0204776.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30261065
Zavadska, D., Odzelevica, Z., Karelis, G., Liepina, L., Litauniece, Z.A., Bormane, A., Lucenko, I., Perevoscikovs, J., Bridina, L., Veide, L., Krumina, A., Storozenko, J., Erber, W., Htar, M.T.T., Schmitt, H.-J. Tick-borne encephalitis: A 43-year summary of epidemiological and clinical data from Latvia (1973 to 2016) (2018) PLoS ONE, 13 (11), art. no. e0204844.2018https://www.ncbi.nlm.nih.gov/pubmed/30422984
Zepa, J., Buliņa, I., Lavrentjevs, V., Vinkalna, I., Ņikitina-Zaķe, L., Andersone, D., Lejnieks, A. The impact of body mass index on disease progression in ankylosing spondylitis (2018) Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 72 (1), pp. 23-28.2018https://www.degruyter.com/downloadpdf/j/prolas.2017.72.issue-1/prolas-2018-0002/prolas-2018-0002.pdf
Falch, C.M., Sundaram, A.Y.M., Øystese, K.A., Normann, K.R., Lekva, T., Silamikelis, I., Eieland, A.K., Andersen, M., Bollerslev, J., Olarescu, N.C. Gene expression profiling of fast- and slow-growing non-functioning gonadotroph pituitary adenomas (2018) European journal of endocrinology, 178 (3), pp. 295-307.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29259037
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Sjomina, O., Pavlova, J., Daugule, I., Janovic, P., Kikuste, I., Vanags, A., Tolmanis, I., Rudzite, D., Polaka, I., Kojalo, I., Liepniece-Karele, I., Isajevs, S., Santare, D., Pirags, V., Pahomova, J., Dzerve, V., Tzivian, L., Erglis, A., Leja, M. Pepsinogen test for the evaluation of precancerous changes in gastric mucosa: A population-based study (2018) Journal of Gastrointestinal and Liver Diseases, 27 (1), art. no. 4, pp. 11-17.2018https://www.ncbi.nlm.nih.gov/pubmed/29557410
Hurmach, Y., Rudyk, M., Svyatetska, V., Senchylo, N., Skachkova, O., Pjanova, D., Vaivode, K., Skivka, L. The effect of intranasally administered tlr3 agonist larifan on metabolic profile of microglial cells in rat with c6 glioma (2018) Ukrainian Biochemical Journal, 90 (6), pp. 110-119.2018http://ukrbiochemjournal.org/2018/11/the-effect-of-intranasally-administered-tlr3-agonist-larifan-on-metabolic-profile-of-microglial-cells-in-rat-with-c6-glioma.html
Kazokaite, J., Niemans, R., Dudutiene, V., Becker, H.M., Leitans, J., Zubriene, A., Baranauskiene, L., Gondi, G., Zeidler, R., Matuliene, J., Tars, K., Yaromina, A., Lambin, P., Dubois, L.J., Matulis, D. Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells (2018) Oncotarget, 9 (42), pp. 26800-26816.2018http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=25508
Fettelschoss-Gabriel, A., Fettelschoss, V., Olomski, F., Birkmann, K., Thoms, F., Bühler, M., Kummer, M., Zeltins, A., Kündig, T.M., Bachmann, M.F. Active vaccination against interleukin-5 as long-term treatment for insect-bite hypersensitivity in horses (2018) European Journal of Allergy and Clinical Immunology, 74 (3), pp. 572-582.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30402930
Endzeliņs, E., Abols, A., Bušs, A., Zandberga, E., Palviainen, M., Siljander, P., Line, A. Extracellular vesicles derived from hypoxic colorectal cancer cells confer metastatic phenotype to non-metastatic cancer cells (2018) Anticancer Research, 38 (9), pp. 5139-5147.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30194161
Nakurte, I., Jekabsons, K., Rembergs, R., Zandberga, E., Abols, A., Line, A., Muceniece, R. Colorectal cancer cell line SW480 and SW620 released extravascular vesicles: Focus on hypoxia-induced surface proteome changes (2018) Anticancer Research, 38 (11), pp. 6133-6138.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30396929
Rovite V, Wolff-Sagi Y, Zaharenko L, Nikitina-Zake L, Grens E, Klovins J. Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results. J Epidemiol. 2018 Mar 24. doi: 10.2188/jea.JE20170079. [Epub ahead of print]2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29576601
Berziņš, U., Matise-Vanhoutana, I., Petersone, I., Duritis, I., Ņikuļšins, S., Bogdanova-Jatniece, A., Kalis, M., Svirskis, Š., Skrastiņa, D., Ezerta, A., Kozlovska, T. Characterisation and in Vivo Safety of Canine Adipose-Derived Stem Cells (2018) Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 72 (3), pp. 160-171.2018https://app.dimensions.ai/details/publication/pub.1101669437
Krumiņa, A., Pliss, L., Zariņa, G., Puzuka, A., Zariņa, A., Lace, B., Elferts, D., Khrunin, A., Limborska, S., Kloviņš, J., Gailite Piekuse, L. Population Genetics of Latvians in the Context of Admixture between North-Eastern European Ethnic Groups (2018) Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 72 (3), pp. 131-151.2018https://www.degruyter.com/view/j/prolas.2018.72.issue-3/prolas-2018-0025/prolas-2018-0025.xml
Moisejevs, G., Gailite, L., Isajevs, S., Nikitina-Zaķe, L., Kempa, I., Jančiauskas, D., Kikuste, I., Siviņš, A., Ancans, G., Leja, M. Lack of Association between Rs2067474 Polymorphism in the Histamine Receptor H2 Gene and Gastric Cancer in Latvian Population (2018) Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 72 (6), pp. 307-312.2018https://www.researchgate.net/publication/330124820_Lack_of_Association_Between_Rs2067474_Polymorphism_in_the_Histamine_Receptor_H2_Gene_and_Gastric_Cancer_In_Latvian_Population
Marcnkiewicz, A.L., Lieknina, I., Kotelovica, S., Yang, X., Kraiczy, P., Pal, U., Lin, Y.-P., Tars, K. Eliminating factor H-Binding activity of Borrelia burgdorferi CspZ combined with virus-like particle conjugation enhances its efficacy as a Lyme disease vaccine (2018) Frontiers in Immunology, 9 (FEB), art. no. 181.2018https://www.frontiersin.org/articles/10.3389/fimmu.2018.00181/full
Garaud, S., Zayakin, P., Buisseret, L., Rulle, U., Silina, K., De Wind, A., Van Den Eyden, G., Larsimont, D., Willard-Gallo, K., Line, A. Antigen specificity and clinical significance of IgG and IgA autoantibodies produced in situby tumor-infiltrating b cells in breast cancer (2018) Frontiers in Immunology, 9 (NOV), art. no. 2660.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=30515157
Herranz, M., Pole, I., Ozere, I., Chiner-Oms, Á., Martínez-Lirola, M., Pérez-García, F., Gijón, P., Serrano, M.J.R., Romero, L.C., Cuevas, O., Comas, I., Bouza, E., Pérez-Lago, L., García-de-Viedma, D. Mycobacterium tuberculosis acquires limited genetic diversity in prolonged infections, reactivations and transmissions involving multiple hosts (2018) Frontiers in Microbiology, 8 (JAN), art. no. 2661.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29403447
Apsite, G., Timofejeva, I., Vezane, A., Vigante, B., Rucins, M., Sobolev, A., Plotniece, M., Pajuste, K., Kozlovska, T., Plotniece, A. Synthesis and comparative evaluation of novel cationic amphiphile C12-Man-Q as an efficient DNA delivery agent in vitro (2018) Molecules, 23 (7), art. no. 1540.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29949910
Kozireva, S., Rudevica, Z., Baryshev, M., Leonciks, A., Kashuba, E., Kholodnyuk, I. Upregulation of the chemokine receptor CCR2B in Epstein-Barr Virus-positive Burkitt lymphoma cell lines with the latency III program (2018) Viruses, 10 (5), art. no. 239.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=29751565
Nakurte I, Jekabsons K, Zandberga E, Abols A, Line A and Muceniece R. Proteome Analysis of Colorectal Cancer Cell Line SW480 Released Extracellular Vesicles (2018) Key Engineering Materials, Vol. 762, pp 3-7. (IF=0.39).2018https://www.scientific.net/KEM.762.3
Zepa, J., Silamiķele, L., Bulina, I., Lavrentjevs, V., Trapina, I., Klovins, J., Andersone, D., Lejnieks, A., Nikitina-Zake, L. CD40 rs4810485 T>G polymorphism and susceptibility to ankylosing spondylitis in the latvian population (2018) Genetics and Molecular Research, 17 (3), art. no. gmr18081.2018https://www.geneticsmr.com/articles/cd40-rs4810485-tg-polymorphism-and
Zole, E., Zadinane, K., Pliss, L., Ranka, R. Linkage between mitochondrial genome alterations, telomere length and aging population (2017) Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis, pp. 1-8.2018https://www.ncbi.nlm.nih.gov/pubmed/?term=28340313
Pashkevych Y, Rudyk M, Hurmach Y, Svyatetska V, Senchylo N, Pjanova D, Feldmane G, Skivka L. Bacteriophage-derived dsRNA of natural origin alters functional profile of rat microglial cells exposed to hypoxia in vitro: Evaluation of metabolic and phenotypic markers (2018) Meta Gene, Volume 17, Supplement 1, Page S22.2018https://www.sciencedirect.com/science/article/pii/S2214540018300847
Leśniak, R.K., Markolovic, S., Tars, K., Schofield, C.J. Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-Nε-trimethyllysine (2017) Chemical Communications, 53 (2), pp. 440-4422017https://www.ncbi.nlm.nih.gov/pubmed/27965989
Hamdi, Y., .... Tihomirova, L., ..... Simard, J. Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3 (2016) Breast Cancer Research and Treatment, pp. 1-18.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=27796716
Dujic, T., Zhou, K., Yee, S.W., van Leeuwen N., de Keyser, C.E., Javorský, M., Goswami, S., Zaharenko. L., Marie, M., Christensen, H., Out, M., Tavendale, R., Kubo, M., Hedderson, M.M., van der Heijden, A.A., Klimčáková, L., Pirags, V., Kooy, A., Brøsen, K., Klovins, J., Semiz, S., Tkáč, I., Stricker, B.H., Palmer, C.N., 't Hart, L.M., Giacomini, K.M., Pearson, E.R. Variants in Pharmacokinetic Transporters and Glycaemic Response to Metformin: A MetGen Meta-Analysis. (2016) Clinical Pharmacology & Therapeutics, Epub ahead of print.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=27859023
Bobileva, O., Ikaunieks, M., Duburs, G., Mandrika, I., Petrovska, R., Klovins, J., Loza, E. Synthesis and evaluation of (E)-2-(5-phenylpent-2 en-4-ynamido)cyclohex-1-ene-1-carboxylate derivatives as HCA2 receptor agonists (2017) Bioorganic and Medicinal Chemistry, 25 (16), pp. 4314-4329.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28668361
McLaughlin, R.L., Schijven, D., ... Klovins, J.,... Nikitina-Zake, L., …. O'Donovan, M.C. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia (2017) Nature Communications, 8, art. no. 147742017https://www.ncbi.nlm.nih.gov/pubmed/?term=28322246
Fridmanis, D., Roga, A., Klovins, J. ACTH receptor (MC2R) specificity: What do we know about underlying molecular mechanisms? (2017) Frontiers in Endocrinology, 8 (FEB), art. no. 13.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28220105
Valassi, E., Franz, H., Brue, T., Feelders, R.A., Netea-Maier, R., Tsagarakis, S., Webb, S.M., Yaneva, M., Reincke, M., Droste, M., Komerdus, I., Maiter, D., Kastelan, D., Chanson, P., Pfeifer, M., Strasburger, C.J., Tóth, M., Chabre, O., Tabarin, A., Krsek, M., Fajardo, C., Bolanowski, M., Santos, A., Wass, J.A.H., Trainer, P.J., Ambrogio, A., Aranda, G., Arosio, M., Balomenaki, M., Beck-Peccoz, P., Berr-Kirmair, C., Bollerslev, J., Carvalho, D., Cavagnini, F., Christ, E., Demtröder, F., Denes, J., Dimopoulou, C., Dreval, A., Dusek, T., Erdinc, E., Evang, J.A., Fazel, J., Fica, S., Ghigo, E., Goth, M., Greenman, Y., Greisa, V., Halperin, I., Hanzu, F.A., Hermus, A., Johannsson, G., Kamenicky, P., Kasperlik-Zaluska, A., Kirchner, J., Kraljevic, I., Kruszynska, A., Lambrescu, I., Lang, S., Luger, A., Marpole, N., Martin, S., Martinie, M., Moros, O., Newell-Price, J., Orbetzova, M., Paiva, I., Giraldi, F.P., Pereira, A.M., Pickel, J., Pirags, V., Ragnarsson, O., Reghina, A.D., Riesgo, P., Roberts, M., Roerink, S., Roig, O., Rowan, C., Rudenko, P., Sahnoun, M.A., Salvador, J., Sigurjonsdottir, H.A., Polovina, T.S., Smith, R., Stachowska, B., Stalla, G., Tóke, J., Ubina, E., Vinay, S., Wagenmakers, M., Werner, S., Young, J., Zdunowski, P., Zopf, K., Zopp, S., Zosin, I. Diagnostic tests for Cushing's syndrome differ from published guidelines: Data from ERCUSYN (2017) European Journal of Endocrinology, 176 (5), pp. 613-624.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28377460
Gerstein, H.C., Colhoun, H.M., Dagenais, G.R., Diaz, R., Lakshmanan, M., Pais, P., Probstfield, J., Riddle, M.C., Rydén, L., Xavier, D., Atisso, C.M., Avezum, A., Basile, J., Chung, N., Conget, I., Cushman, W.C., Franek, E., Hancu, N., Hanefeld, M., Holt, S., Jansky, P., Keltai, M., Lanas, F., Leiter, L.A., Lopez-Jaramillo, P., Cardona-Munoz, E.G., Pirags, V., Pogosova, N., Raubenheimer, P.J., Shaw, J., Sheu, W.H.-H., Temelkova-Kurktschiev, T. Design and baseline characteristics of participants in the Researching cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) trial on the cardiovascular effects of dulaglutide (2017) Diabetes, Obesity and Metabolism.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28573765
Krams IA, Kecko S, Jõers P, Trakimas G, Elferts D, Krams R, Luoto S, Rantala MJ, Inashkina I, Gudrā D, Fridmanis D, Contreras-Garduño J, Grantiņa-Ieviņa L, Krama T. Microbiome symbionts and diet diversity incur costs on the immune system of insect larvae. (2017) (2017) Journal of Experimental Biology, 220 (22), pp. 4204-4212.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28939559
Stavusis J, Inashkina I, Lace B, Pelnena D, Limborska S, Khrunin A, Kucinskas V, Krumina A, Piekuse L, Zorn B, Fodina V, Punab M, Erenpreiss J. A New Baltic Population Specific Human Genetic Marker in the PMCA4 Gene. (2017) Human Heredity, 82 (3-4), pp. 140-146.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=29131013
Erenpreiss, J., Punab, M., Zilaitiene, B., Hlevicka, S., Zayakin, P., Matulevicius, V., Preiksa, R.T., Jørgensen, N. Semen quality of young men from the general population in Baltic countries (2017) Human Reproduction, 32 (6), pp. 1334-1340.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28383690
Cipriani, V., Silva, R.S., Arno, G., Pontikos, N., Kalhoro, A., Valeina, S., Inashkina, I., Audere, M., Rutka, K., Puech, B., Michaelides, M., Van Heyningen, V., Lace, B., Webster, A.R., Moore, A.T. Duplication events downstream of IRX1 cause North Carolina macular dystrophy at the MCDR3 locus (2017) Scientific Reports, 7 (1), art. no. 7512.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28790370
Salmina, K., Huna, A., Inashkina, I., Belyayev, A., Krigerts, J., Pastova, L., Vazquez-Martin, A., Erenpreisa, J. Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells (2017) Nucleus, 8 (2), pp. 205-221.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28068183
Ziemele, B., Ranka, R., Ozere, I. Pediatric and adolescent tuberculosis in Latvia, 2011-2014: Case detection, diagnosis and treatment (2017) International Journal of Tuberculosis and Lung Disease, 21 (6), pp. 637-644.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28482957
Baumane, K., Ranka, R., Laganovska, G. The effect of glaucoma filtration surgery on structural and functional eye parameters in a short-term study (2017) Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 71 (1-2), pp. 27-32.2017https://www.degruyter.com/view/j/prolas.2017.71.issue-1-2/prolas-2017-0005/prolas-2017-0005.xml
Taylor NJ, Mitra N, Goldstein AM, Tucker MA, Avril MF, Azizi E, Bergman W, Bishop DT, Bressac-de Paillerets B, Bruno W, Calista D, Cannon-Albright LA, Cuellar F, Cust AE, Demenais F, Elder DE, Gerdes AM, Ghiorzo P, Grazziotin TC, Hansson J, Harland M, Hayward NK, Hocevar M, Höiom V, Ingvar C, Landi MT, Landman
G, Larre-Borges A, Leachman SA, Mann GJ, Nagore E, Olsson H, Palmer JM, Perić B, Pjanova D, Pritchard A, Puig S, van der Stoep N, Wadt KAW, Whitaker L, Yang XR, Newton Bishop JA, Gruis NA, Kanetsky PA; GenoMEL Study Group. Germline variation at CDKN2A and associations with nevus phenotypes among members of melanoma families. (2017) Journal of Investigative Dermatology, 137 (12), pp. 2606-2612.		2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28830827
Rodríguez M, Bajo-Santos C, Hessvik NP, Lorenz S, Fromm B, Berge V, Sandvig K, Linē A, Llorente A. Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes. (2017) Mol Cancer, Oct 5;16(1):156.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28982366
Meistere I, Werner S, Zayakin P, Siliņa K, Rulle U, Pismennaja A, Šantare D, Kikuste I, Isajevs S, Leja M, Kupčinskas L, Kupčinskas J, Jonaitis L, Wu CY, Brenner H, Linē A, Kalniņa Z. The prevalence of cancer-associated autoantibodies in patients with gastric cancer and progressive grades of premalignant lesions. (2017) Cancer Epidemiology Biomarkers Prev., Oct;26(10):1564-1574.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28768706
Zandberga E, Zayakin P, Ābols A, Pūpola D, Trapencieris P and Linē A. Depletion of carbonic anhydrase IX abrogates hypoxia-induced overexpression of stanniocalcin-1 in triple negative breast cancer cells. (2017) Cancer Biol Ther, Jun 30:1-10.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28665755
Zajakina A, Spunde K, Lundstrom K. Application of alphaviral vectors for immunomodulation in cancer therapy. (2017) Curr Pharm Des, Jun 21.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28641531
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Kholodnyuk, I., Rudevica, Z., Leonciks, A., Ehlin-Henriksson, B., Kashuba, E. Expression of the chemokine receptors CCR1 and CCR2B is up-regulated in peripheral blood B cells upon EBV infection and in established lymphoblastoid cell lines (2017) Virology, 512, pp. 1-7.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28892735
Bianco, G., Meleddu, R., Distinto, S., Cottiglia, F., Gaspari, M., Melis, C., Corona, A., Angius, R., Angeli, A., Taverna, D., Alcaro, S., Leitans, J., Kazaks, A., Tars, K., Supuran, C.T., Maccioni, E. N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms (2017) ACS Medicinal Chemistry Letters, 8 (8), pp. 792-796.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28835790
Cala-De Paepe, D., Stanek, J., Jaudzems, K., Tars, K., Andreas, L.B., Pintacuda, G. Is protein deuteration beneficial for proton detected solid-state NMR at and above 100 kHz magic-angle spinning? (2017) Solid State Nuclear Magnetic Resonance, . Article in Press.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28802890
Pustenko, A., Stepanovs, D., Žalubovskis, R., Vullo, D., Kazaks, A., Leitans, J., Tars, K., Supuran, C.T. 3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors (2017) Journal of Enzyme Inhibition and Medicinal Chemistry, 32 (1), pp. 767-775.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28537099
Ivanova, J., Carta, F., Vullo, D., Leitans, J., Kazaks, A., Tars, K., Žalubovskis, R., Supuran, C.T. N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII (2017) Bioorganic and Medicinal Chemistry, 25 (13), pp. 3583-3589.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28416101
Rumnieks, J., Tars, K. Crystal Structure of the Maturation Protein from Bacteriophage Qβ (2017) Journal of Molecular Biology, 429 (5), pp. 688-696.2017https://www.ncbi.nlm.nih.gov/pubmed/?term=28111107
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