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Human genetics and disease mechanisms

BMC research in basic medicine represents human genetics, studies of disease-associated molecular mechanisms, identification of biomarkers, and development of molecular diagnostic tools. During the past years, a significant BMC achievement is creating and exploring a unique biobank resource, the Genome Database of Latvian Population (LGDB), consisting of more than 35 000 population-based participants patients of different disease cohorts. This biobank has been the primary source for expanding genetic and clinical studies in BMC and prepared the ground for more advanced integrated studies. Five research groups working in this direction represent a primary driving force of translational medicine in Latvia combining the clinical, epidemiological, genomic, and other omics-based studies complemented with functional evaluation in order to understand the molecular basis of disease and drug action mechanisms and develop diagnostic and treatment solutions in various common and rare, as well as infectious diseases. The overall strategic goal of BMC in this area is to develop and promote translational medicine studies, including the identification of biomarkers and the development of molecular diagnostic and therapy approaches.

Prof. Kloviņš group uses different omics technologies to understand the mechanisms driving the disease development and drug action of metabolic and gut-related diseases. A particular focus is on the processes affected by the microbiome. The main focus of Dr. Innashkinas group is the study of human genetic pathology to identify the causative genes in novel inherited diseases and their molecular mechanisms using cellular and transgenic animal models. Dr. Fridmanis group performs microbiome research from a broad range of environments and continues functional studies of G-protein coupled receptors. Prof. Rankas group investigates the molecular bases of different biological functions of medically-important pathogens, focusing on pathogen-host interaction in tuberculosis and different tick-borne infections. Recently established Dr. Rovites group studies the molecular factors in the pituitary neuroendocrine tumors and their development mechanisms to find diagnostic markers and improve disease management.

J. Kloviņš lab

R. Ranka lab

I. Inashkina lab

D. Fridmanis lab

V. Rovite lab