Project title: Genomic Data Infrastructure

Acronym: GDI

Project No.: 101168231

Call for proposal: DIGITAL-2023-CLOUD-AI-04

Period: 1 October 2024 – 31 March 2028

Estimated Project Cost: €44,465,986.08

Requested EU Contribution: €20,000,000.00

Leader of Latvian team: Dr. biol. Jānis Kloviņš

Coordinator: ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Project summary:

The Genome of Europe (GoE) project encompasses 48 partners across 27 European countries (26 EU+1 non-EU) to establish a unique pan-European reference database comprising a minimum of 100,000 genomes representative of European citizens in alignment with the 1+ Million Genomes initiative. Key objectives include implementing a pan-European community of practice that will generate the reference genome through integration of existing genome datasets and de novo sequencing from diverse national populations, defining the ethical, legal and societal conditions for generating the reference genome, ensuring data security, and embedding GoE data within the Digital Europe Programme-funded Genomic Data Infrastructure. The value and usability of the GoE will be assessed through use cases focusing on genetic diversity, establishing multi-ancestry imputation services, and recalibrating genetic risk

profiles. Beyond the project, GoE will be highly relevant for genetic-phenotypic discoveries, helping national genome programs, and integration of genomics into the European Health Data Space (EHDS). The GoE project prioritizes public engagement, transparency, and adaptability for future extensions, ensuring responsible and sustainable genomic advancements. Integration with other European initiatives enhances its potential impact for personalized medicine, and aligns with broader scientific and healthcare goals including the European competitiveness in genomic research and innovation.

Information published 01.10.2024.