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LATVIAN

BIOMEDICAL

RESEARCH AND STUDY CENTRE


RESEARCH AND EDUCATION IN BIOMEDICINE FROM GENES TO HUMAN

Project title: Beyond 1 Million Genomes Plus (B1MGPlus)

Funding IGITAL-2024-CLOUD-DATA-AI-06-GENOME

Project No.: 101194865

Period: 1 February 2025 – 31 January 2028

Project costs: 2 000 000,00 EUR

Coordinator: EUROPEAN MOLECULAR BIOLOGY LABORATORY

Latvian Biomedical Research and Study Centre (Associated partner)

Project web page: https://b1mgplus.onemilliongenomes.eu/about

Project summary:

The EU Member States’ initiative 1+ Million Genomes (1+MG) aims to enable secure access to genomic and corresponding clinical data across Europe, supporting research, health policy and personalised healthcare. This initiative follows a two-staged roadmap, via the Beyond 1M Genomes and European Genomic Data Infrastructure projects, alongside 1+MG Working Groups and National Mirror Groups. The Genome of Europe project will build a European network of national genomic reference cohorts. B1MGplus aims to support the scale up and sustainability of 1+MG by supporting Member States to create a federated European genomics data infrastructure based on a European Digital Infrastructure Consortium (EDIC). It will also facilitate the uptake of genomics into healthcare delivery and public health policy, while developing the guidelines for meta-data standards and data quality assurance within the 1+MG Framework.

B1MGplus activities include: -Preparation of Genome EDIC: drafting of legal and policy documents for operational readiness, supporting GDI Pillar I for long-term sustainability, setting up risk management frameworks and stakeholder interaction plans -Facilitating strategic orientation of the 1+MG initiative -Facilitating the uptake of genomics for healthcare: promoting awareness and engagement of public health professionals, encouraging the maturity assessment of genomics in healthcare systems, creating a citizens’ hub for disseminating information on genomics, supporting the demonstration of the economic impact of genomics medicine on healthcare -Developing data standards, ontologies, and sequencing practices to ensure that data made available is 1+MG-ready B1MGplus advances the 1+MG initiative, fostering genomic medicine and personalised healthcare. This project will contribute to unlocking the promise of genomics for healthcare and public health, creating unprecedented opportunities in cancer, common and rare diseases, infectious diseases and pharmacogenomics.

Information published 18.07.2025.