Cancer Biomarkers Group (A.Linē lab)
The main focus of our group is the discovery and validation of blood-based biomarkers for the early detection, monitoring, and prognosis of cancer. Initially, our research centred on autoantibodies against tumour antigens. Using our Cancer Antigen Collection, comprising more than 1,800 antigens, together with antigen microarray technology, we evaluated their diagnostic and prognostic relevance in gastric, thyroid, prostate, and breast cancers. Currently, our primary research area is the investigation of the molecular cargo, functional roles, and therapeutic potential of extracellular vesicles (EVs). More recently, we have initiated a new research direction aimed at elucidating the molecular mechanisms underlying the effects of physical activity on cancer progression and treatment response.
Aija Linē, PhD
Head of scientific group, senior researcher
Personnel
Prof. Aija Linē, Dr. biol., aija@biomed.lu.lv
Pavels Zajakins, Dr. biol., pawel@biomed.lu.lv
Nadežda Romančikova, Dr. biol., nadezda.romancikova@biomed.lu.lv
Edgars Endzeliņš, MSc. biol., edgars.endzelins@biomed.lu.lv
Lilite Sadovska, Dr. biol., lilite@biomed.lu.lv
Agnese Brokāne, MSc. biol., agnese.brokane@biomed.lu.lv
Kristaps Eglītis, certified surgeon, kristaps.eglitis@biomed.lu.lv
Diāna Skorinkina, diana.skorinkina@biomed.lu.lv
Aleksandrs Dumešs, aleksandrs.dumess@biomed.lu.lv
Elza Bojāre, elza.bojare@biomed.lu.lv
Areas for searching partners
- Novel technologies or tools for the detection and/or analysis of EVs
- Clinical validation of liquid biopsies and EV-based cancer biomarkers
- Use of artificial intelligence and machine learning for the generation of diagnostic algorithms
- Elucidation of molecular mechanisms underlying the effects of physical activity on cancer progression and treatment response.
10 the most representative publications for the scientific group
- Llorente A, Brokāne A, Mlynska A, Puurand M, Sagini K, Folkmane S, Hjorth M, Martin-Gracia B, Romero S, Skorinkina D, Čampa M, Cešeiko R, Romanchikova N, Kļaviņa A, Käämbre T, Linē A. From sweat to hope: The role of exercise-induced extracellular vesicles in cancer prevention and treatment. J Extracell Vesicles. 2024 Aug;13(8):e12500. PMID: 39183543
- Bajo-Santos C., Brokāne A., Zayakin P., Endzeliņš E., Soboļevska K., Belovs A., Jansons J., Sperga M., Llorente A., Radoviča/Spalviņa I., Lietuvietis V., Linē A. Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies. Front. Mol. Biosci. 2023, PMID: 36818049
- Sadovska L, Auders J, Keiša L, Romanchikova N, Silamiķele L, Kreismane M, Zayakin P, Takahashi S, Kalnina Z and Linē A, Exercise-induced Extracellular Vesicles Delay the Progression of Prostate Cancer. Front. Mol. Biosci. 2022 Jan 11;8:784080. PMID: 35087866.
- Sadovska L, Zayakin P, Bajo-Santos C, Endzeliņš E, Auders J, Keiša L, Jansons J, Lietuvietis V, Linē A. Effects of urinary extracellular vesicles from prostate cancer patients on the transcriptomes of cancer-associated and normal fibroblasts. BMC Cancer. 2022 Oct 12;22(1):1055. PMID: 36224527
- Plūme J, Galvanovskis A, Šmite S, Romanchikova N, Zayakin P, Linē A. Early and strong antibody responses to SARS-CoV-2 predict disease severity in COVID-19 patients. J Transl Med. 2022 Apr 15;20(1):176. PMID: 35428263.
- Vasconcelos MH, Caires HR, Ābols A, Xavier CPR, Linē A Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance. Drug Resist Updat. 2019 Dec;47:100647. PMID: 31704541.
- Garaud S, Zayakin P, Buisseret L, Rulle U, Siliņa K, de Wind A, den Eyden GV, Larsimont D, Willard-Gallo K, Linē A. Antigen specificity and clinical significance of IgG and IgA autoantibodies produced in situ by tumor-infiltrating B cells in breast cancer. Frontiers in Immunology. 2018 Nov 20;9:2660. PMID: 30515157
- Popēna I, Ābols A, Saulīte L, Pleiko K, Zandberga E, Jēkabsons K, Endzeliņš E, Llorente A, Linē A, Riekstiņa U. Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages. Cell Commun Signal. 2018 Apr 24;16(1):17. PMID: 29690889.
- Silina K, Soltermann A, Movahedian Attar F, Casanova R, Uckeley ZM, Thut H, Wandres M, Isajevs S, Cheng PF, Curioni Fontecedro A, Foukas P, Levesque MP, Moch H, Linē A, van den Broek M. Germinal centers determine the prognostic relevance of tertiary lymphoid structures and are impaired by corticosteroids in lung squamous cell carcinoma. Cancer Res. 2018 Mar 1;78(5):1308-1320. PMID: 29279354
- Endzeliņš E, Berger A, Melne V, Bajo-Santos C, Soboļevska K, Ābols A, Rodriguez M, Šantare D, Rudņickiha A, Lietuvietis V, Llorente A, Linē A. Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate cancer patients. BMC Cancer. 2017 Nov 9;17(1):730. PMID: 29121858.