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   2009
BMC publikācijas, 2009. gads
Publikācijas starptautiskos zinātniskos žurnālos:
1.         Zhang W, Caspell R, Karulin AY, Ahmad M, Haicheur N, Abdelsalam A, Johannesen K, Vignard V, Dudzik P, Georgakopoulou K, Mihaylova A, Silina K, Aptsiauri N, Adams V, Lehmann PV, McArdle S. ELISPOT assays provide reproducible results among different laboratories for T cell immune monitoring – even in hands of ELISPOT-inexperienced investigators. J Immunotoxicol, 2009 Dec; 6(4):227-34.
2.      Jumutcs V, Zayakin P, Linē A. Antigen Reduction Applied to Support Vector Machine Classification for Melanoma-Related Diagnostics. Polish J. of Environ. Stud, 2009, 18 (4A):3-7.
3.      Kalnina Z, Silina K, Bruvere R, Gabruseva N, Stengrevics A, Barnikol-Watanabe S, Leja M, Line A. Molecular characterisation and expression analysis of SEREX-defined antigen NUCB2 in gastric epithelium, gastritis and gastric cancer. Eur J Hisopathol, 2009, Jan-Mar; 53 (1):7-18.
4.      Pumpens P., Ulrich R., Sasnauskas K., Kazaks A., Ose V., Grens E. Construction of novel vaccines on the basis of the virus-like particles: Hepatitis B virus proteins as vaccine carriers, In: Y.Khudyakov (Ed.). Medicinal Protein Engineering. CRC Press, Taylor & Francis Group, Boca Raton London, New York, 2009, pp. 205-248.
5.      Rabe B, Delaleau M, Bischof A, Foss M, Sominskaya I, Pumpens P, Cazenave C, Castroviejo M, Kann M Nuclear entry of hepatitis B virus capsids involves disintegration to protein dimers followed by nuclear reassociation to capsids. PLoS Pathog. 2009 Aug;5(8):e1000563. Epub 2009 Aug 28.
6.      Alekseeva E, Sominskaya I, Skrastina D, Egorova I, Starodubova E, Kushners E, Mihailova M, Petrakova N, Bruvere R, Kozlovskaya T, Isaguliants M, Pumpens P. Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regiment. Genet Vaccines Ther. 2009 Jun 8;7(1):7.  
7.      Sendi H., Mehrab-Mohseni M., Shahraz S., Norder H., , Noorinayer B., Zali M.R., Pumpens P.,  Magnius L.O. CTL escape mutation of core protein are more frequent in strains of HBeAg negative patients with low viral load. 2009. J. Clin. Virol., Sep 1. Nov;46(3):259-264. Epub 2009 Sep 12  
8.      Bessa J, Jegerlehner A, Hinton HJ, Pumpens P, Saudan P, Schneider P, Bachmann MF Alveolar Macrophages and Lung Dendritic Cells Sense RNA and Drive Mucosal IgA Responses. J Immunol. 2009 Sep 15;183(6):3788-99. Epub 2009 Aug 26.
9.      Sominskaya I, Mihailova M, Jansons J, Legzdina D, Pumpens P, Arsha F, Keish J, Sondore V, Rozentale B, Viksna L. Epidemiological study of Hepatitis B virus genotypes in Latvia. 2009. Submitted to The Open Hepatology Journal.
10.      Bremer CM, Sominskaya I, Skrastina D, Pumpens P, Abd El Wahed A, Beutling U, Frank R, Fritz HI, Hunsmann G, Gerlich WH, Glebe D. Neutralizing epitopes in the preS1 attachment site of hepatitis B virus are partially masked by N-terminal myristoylation. 2009, submitted to the PLoS ONE.  
11.      De-Almeida D.E., Ling S., Pi M., Hartmann-Scruggs A.M., Pumpens P., Holoshitz J. Immune dysregulation by the rheumatoid arthritis shared epitope. 2009, submitted to J. Immunol.  
12.      Ling S., Cheng A., Pumpens P., Michalak M., Holoshitz J. Mapping of the Rheumatoid Arthritis Shared Epitope Binding Site on Calreticulin. 2009, submitted to the PNAS.
13.      Ulrich R.G., Gedvilaite A., Voronkova T., Kazaks A., Sasnauskas K., Johne R. Polyoma-virus derived virus-like particles, In: Y.Khudyakov (Ed.). Medicinal Protein Engineering. CRC Press, Taylor & Francis Group, Boca Raton London, New York, 2009, pp. 249-275.
14.      Kazaks A., Voronkova T. Papilloma-virus derived virus-like particles, In: Y.Khudyakov (Ed.). Medicinal Protein Engineering. CRC Press, Taylor & Francis Group, Boca Raton London, New York, 2009, pp. 277-297.
15.      Zeltins A. Plant virus biotechnology platforms for expression of medicinal proteins, In: Y.Khudyakov (Ed.). Medicinal Protein Engineering. CRC Press, Taylor & Francis Group, Boca Raton London, New York, 2009, pp. 481-517.
16.      Zajakina A., Niedre-Otomere B., Alekseeva E., Kozlovska T.  Alphaviruses: multiplicity of vectors and their promising application as vaccines and cancer therapy agents, In: Y.Khudyakov (Ed.). Medicinal Protein Engineering. CRC Press, Taylor & Francis Group, Boca Raton London, New York, 2009, pp. 277-297.
17.      Plevka P, Kazaks A, Voronkova T, Kotelovica S, Dishlers A, Liljas L, Tars K. The structure of bacteriophage phiCb5 reveals a role of the RNA genome and metal ions in particle stability and assembly. J Mol Biol. 2009 Aug 21;391(3):635-47.  
18.      Rumnieks J, Ose V, Tars K, Dislers A, Strods A, Cielens I, Renhofa R. Assembly of mixed rod-like and spherical particles from group I and II RNA bacteriophage coat proteins. Virology. 2009 Sep 1;391(2):187-94.  
19.      Plevka P, Tars K, Liljas L. Structure and stability of icosahedral particles of a covalent coat protein dimer of bacteriophage MS2. Protein Sci. 2009 Aug;18(8):1653-61.
20.      Balogh LM, Le Trong I, Kripps KA, Tars K, Stenkamp RE, Mannervik B, Atkins WM. Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals. Biochemistry. 2009 Aug 18;48(32):7698-704.
21.      Plevka P, Tars K, Liljas L. Structure and stability of icosahedral particles of a covalent coat protein dimer of bacteriophage MS2. Protein Sci. 2009 Aug;18(8):1653-61.
22.      Balogh LM, Le Trong I, Kripps KA, Tars K, Stenkamp RE, Mannervik B, Atkins WM. Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals. Biochemistry. 2009 Aug 18;48(32):7698-704.
23.      Ranka R., Brangulis K., Capligina V., Sondore V., Baumanis V. antigenicity of recombinant fibronectin binding protein fragments in Lyme disease. The FEBS Journal 2009, v.276, S1, 162-163
24.      Pelnena I., Pliss L., Baumanis V., Krumina A., Kucinskas V., Kasperaviciute D. The genetic component of the Baltic- speaking populations revealed by a wide set of Y chromosomal markers using phylogeographic approach. The FEBS Journal 2009, v.276, S1, 1a.
25.      Pliss L., Brakmanis A., Baumanis V., Krumina A., Rozane S., Sabule A.molecular study of genetic association between mitochondrial DNA heteroplasmy and ageing process among healthy unrelated Latvians. The FEBS Journal 2009, v.276, S1, 1b.
26.      F.Ianzini, E.A. Kosmacek, E.S. Nelson, E. Napoli, J. Erenpreisa, M. Kalejs, M. A. Mackey. Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation induced mitotic catastrophe. Cancer Res 2009, 69:2296-304.
27.      Tsarev I, Bungum M, Giwercman A, Erenpreisa J, Ebessen T, Ernst E, Erenpreiss J. Evaluation of male fertility potential by Toluidine Blue test for sperm chromatin structure assessment. Hum Reprod 2009, 24:1569-74.
28.      Erenpreisa J, Cragg MS, Salmina K, Hausmann M, Scherthan H. The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells. Exp Cell Res. 2009, 315:2593-603.  
29.      Ivanov A, Beers SA, Walshe CA, Honeychurch J, Alduaij W, Cox KL, Potter KN, Murray S, Chan CH, Klymenko T, Erenpreisa J, Glennie MJ, Illidge TM, Cragg MS. Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. J Clin Invest. 2009, 119:2143-59.  
30.      Erglis K., Ose V., Zeltins A., Cebers. Viscoelastisticity of the bacteriophage Pf1 network measured by magnetic microrheology. Magnetohydrodynamics, 2010, Vol. 46, 3–9.
31.      I.Sominskaya, D.Skrastiņa, A.Dislers, D.Vasiljev, M.Mihailova, V.Ose-Klinklava, Dz.Dreilina, P.Pumpens Construction and immunological evaluation of multivalent Hepatitis B core VLPs carryng HBV and HCV epitopes. Clinical and Vaccine Immunology, in revision.  
32.      Pjanova D, Molven A, Akslen LA, Streinerte B, Engele L, Azarjana K, and Heisele O. Identification of a CDK4 R24H mutation-positive melanoma family by analysis of early-onset melanoma patients in Latvia. Melanoma Res. 2009; 19:119-122.  
33.      Kalniņa I, Bruvere R, Zvagule T, Gabruseva N, Klimkane L,  Kirilova J,  Meirovics I,  Kizane G. Fluorescence Probe ABM and Estimation of Immune State in Patients with Different Pathologies (Review Article). J. of Fluorescence, 2009. DOI 10.1007/s10895-009-1515-6.
34.      Nelis, M., Esko, T., Magi, R., Zimprich, F., Zimprich, A., Toncheva, D., Karachanak, S., Piskackova, T., Balascak, I., Peltonen, L., Jakkula, E., Rehnstrom, K., Lathrop, M., Heath, S., Galan, P., Schreiber, S., Meitinger, T., Pfeufer, A., Wichmann, H. E., Melegh, B., Polgar, N., Toniolo, D., Gasparini, P., D'Adamo, P., Klovins, J., Nikitina-Zake, L., Kucinskas, V., Kasnauskiene, J., Lubinski, J., Debniak, T., Limborska, S., Khrunin, A., Estivill, X., Rabionet, R., Marsal, S., Julia, A., Antonarakis, S. E., Deutsch, S., Borel, C., Attar, H., Gagnebin, M., Macek, M., Krawczak, M., Remm, M. & Metspalu, A. (2009). Genetic structure of Europeans: a view from the North-East.  PLoS One. 2009;4(5):e5472. Epub 2009 May 8.
35.      Kontijevskis, A., Petrovska, R., Yahorava, S., Komorowski, J. & Wikberg, J. E. (2009). Proteochemometrics mapping of the interaction space for retroviral proteases and their substrates. Bioorg Med Chem 17, 5229-37.
36.      Kalnina, I., Kapa, I., Pirags, V., Ignatovica, V., Schioth, H. B. & Klovins, J. (2009). Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI. BMC Med Genet 10, 63.
37.      Shastry, A., Sedimbi, S. K., Rajalingam, R., Nikitina-Zake, L., Rumba, I., Wigzell, H. & Sanjeevi, C. B. (2008). Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians. Int J Immunogenet 35, 439-46.
 
Publikācijas vietējos zinātniskos un populārzinātniskos žurnālos:
38.      Sudmale G, Jansons J, Sominska I, Sondore V, Jēruma A, Arša F, Keišs J, Rozentāle B, Vīksna L, Pumpēns P. HCV genoma izmaiņas pretvīrusu terapijas gaitā hroniskas HCV infekcijas gadījumā (HCV genome changes during antiviral therapy of chronic HCV infection). 2009, RSU Raksti, pieņemts.
39.      Legzdiņa D, Keišs J, Sudmale G, Sominska I, Arša F, Davidjuka I, Sondore V, Vīksna L, Rozentāle B, Pumpēns P. HBV genoma mutācijas ar lamivudīnu ārstētiem B vīrushepatīta pacientiem Latvijā (Mutations of HBV genomes in lamivudine-treated hepatitis B patients in Latvia). 2009, RSU Raksti, pieņemts.  
40.      Ranka R., Capligina V., Brangulis K., Sondore V., Baumanis V. Cloning and expression of a recombinant immunogenic truncated BBK32 protein of Borrelia afzelli. Acta Universitatis Latviensis, 2009, vol.753,pp33-42.
41.      Pjanova D. Azarjana K, Čēma I, and Heisele O. Genetic alterations in melanoma development Proc. Latvian Acad. Sci. Section B. Vol.63 (2009), No. 3 (662), pp. 20-30.
42.      Kurjāne N, Brūvere R, Gabruševa N, Hagina E, Zvagule T, Jaunalksne I, Feldmane G, Volrāte A, Voskresenska N. Ageing and production of the cytokines in Chernobyl clean-up workers from Latvia. Procceedings of the Latvian Academy of Science, Section B, Vol. 63(2009). No.3 (662), pp.87-92.
43.      Ranka R., Capligina V., Brangulis K., Sondore V., Baumanis V. Cloning and expression of a recombinant immunogenic truncated BBK32 protein of Borrelia afzelli. Acta Universitatis Latviensis, 2009, vol.753,pp33-42.
44.      Pjanova D. Azarjana K, Čēma I, and Heisele O. Genetic alterations in melanoma development Proc. Latvian Acad. Sci. Section B. Vol.63 (2009), No. 3 (662), pp. 20-30.
45.      Kurjāne N, Brūvere R, Gabruševa N, Hagina E, Zvagule T, Jaunalksne I, Feldmane G, Volrāte A, Voskresenska N. Ageing and production of the cytokines in Chernobyl clean-up workers from Latvia. Proc. Latvian Acad. Sci. Section B, Vol. 63(2009). No.3 (662), pp.87-92.
46.      1.Jumutcs V, Zayakin P and Linē A. Applying ANN ensembles to melanomas –related diagnostics on cancer patients. Scientific Proceedings of Riga Technical University, Computer Science, 2008 (5): 100-108.
47.      2.E. Salna, K. Siliņa, J. Šaripova, A. Linē, N. Sjakste. Kvercetīna un kemferola ietekme uz iNOS ekspresiju kontroles un LPS inducēta iekaisuma gadījumā Wistar līnijas žurku aknās. LU Akadēmiskajais apgāds „LU Raksti. Medicīna", Nr 735., 2008. gads
48.      3.Linē A. Līcis N. One drug does not fit all. Doctus, 2005, 3:45-48 [in Latvian]
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Date: 26.03.2010 at 14:33:38
   2008

Publikācijas 2008
 
1.      Hegazy UM, Tars K, Hellman U, Mannervik B. Modulating catalytic activity by unnatural amino acid residues in a GSH-binding loop of GST P1-1. J Mol Biol. 2008 Feb 22;376(3):811-26.
2.      Erenpreisa J, Ivanov A, Wheatley SP, Kosmacek EA, Ianzini F, Anisimov AP, Mackey M, Davis PJ, Plakhins G, Illidge TM. Endopolyploidy in irradiated p53-deficient tumour cell lines: Persistence of cell division activity in giant cells expressing Aurora-B kinase. Cell Biol Int  2008, 32: 1044-1056.
3.      Erenpreisa J and Cragg MS. Life-cycle features of tumour cells. P. Pontarotti (ed.), Evolutionary Biology from Concept to Application,_Springer-Verlag Berlin Heidelberg 2008, Chapter 4, pp. 61-70.
 
4.      Ivanov, M. Ivanova, J. Erenpreisa, S.V. Gloushen, T. Freivalds and M.S. Cragg. Image analysis of DNA repair and apoptosis in tumor cells with differing sensitivity to DNA damage. Alexei Katashev, Yuri Dekhtyar, Janis Spigulis (Eds.) 14th Nordic-Baltic Conference on Biomedical Engineering (NBS) 2008, Proceedings Vol. 20, pp. 524–527.  Springer-Verlag Berlin Heidelberg 2008. www.springerlink.com/index/q01u279103875026.pdf
 
5.      Freivalds J.,Rūmnieks J.,Ose V.,Renhofa R.,Kazāks A., High-level expression and purification of bacteriophage GA virus-like particles from yeast Saccharomyces cerevisae and Pichia pastoris, Acta Universitatis Latviensis, ser.biol. Biology,pp.75-85,2008
6.      Rūmnieks J.,Freivalds J.,Cielēns I.,Renhofa R.,Specificity of packaging mRNA in bacteriophage GA virus-like particles in yeast Saccharomyces cerevisiae, Acta Univerisatis Latviensis,ser.biol, 745, 145-154, 2008.
7.      Skrastina D.,Bulavaite A.,Sominskaya I.,Kovalevska L.,OseV.,Priede D. Pumpens P. Sasnauskas K., High immunogenicity of a hydrophilic component of the hepatitis B virus preS1 sequence exposed on the surface of three virus-like particle carriers, Vaccine,26,1972-1981,2008.
 
8.      Kalniņa Z, Siliņa K and Linē A. Autoantibody profiles as biomarkers for response to therapy and early detection of cancer Current Cancer Therapy Reviews, 2008, 4 (2):149-156.
9.      Kalniņa Z, Siliņa K, Meistere I, Zayakin P, Rivosh A, Ābols A, Leja M, Minenkova O, Schadendorf D and Linē A. Evaluation of T7 and Lambda phage display systems for survey of autoantibody profiles in cancer patients. J Immunol Methods, 2008 May 20;334(1-2):37-50.
10.      Jumutcs V, Zayakin P and Linē A. Applying ANN ensembles to melanomas –related diagnostics on cancer patients. Scientific Proceedings of Riga Technical University 2008. Computer Science, 2008 (5): 100-108.
11.      Zeltins A. Plant Virus Biotechnology Platforms for Expression of Medicinal Proteins. In: Medicinal Protein Engineering, Khudyakov Y., (Ed.), CRC Press, Boca Raton, London, N.Y., W.D.C., 2008, pp. 481-515.
 
12.      Jacobsson JA, Danielsson P, Svensson V, Klovins J, Gyllensten U, Marcus C, Schioth HB, Fredriksson R: Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochem Biophys Res Commun 2008, 368(3):476-482.
 
 
13.      Jacobsson JA, Klovins J, Kapa I, Danielsson P, Svensson V, Ridderstrale M, Gyllensten U, Marcus C, Fredriksson R, Schioth HB: Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents. Int J Obes (Lond) 2008, 32(11):1730-1735.
 
14.      Mandrika I, Prusis P, Bergstrom J, Yahorava S, Wikberg JE: Improving the affinity of antigens for mutated antibodies by use of statistical molecular design. J Pept Sci 2008, 14(7):786-796.
15.      Prusis P, Lapins M, Yahorava S, Petrovska R, Niyomrattanakit P, Katzenmeier G, Wikberg JE: Proteochemometrics analysis of substrate interactions with dengue virus NS3 proteases. Bioorg Med Chem 2008, 16(20):9369-9377.
16.      Kazaks A., Balmaks R., Voronkova T., Ose V., Pumpens P. Melanoma vaccine candidates from chimeric hepatitis B core virus-like particles carrying a tumor-associated MAGE-3 epitope. Biotechnol J 3, 1429–1436, 2008
 
17.      Ulrich R., Gedvilaite A., Voronkova T., Kazaks A., Johne R., and Sasnauskas K. Polyomavirus-derived virus-like particles. In: Khudyakov, Y. (Ed.), Medicinal Protein Engineering, CRC Press 2008, pp. 249-275.  
 
18.      Zajakina A, Niedre-Otomere B, Alekseeva J, and Kozlovska T  Alphaviruses: Multiplicity of Vectors and Their Promising Application as Vaccines and Cancer Therapy Agents, In: Khudyakov, Y. (Ed.), Medicinal Protein Engineering, CRC Press 2008,  pp. 519-550.  
 
19.      Kazaks A., and Voronkova T. Papillomavirus-derived virus-like particles. In: Khudyakov, Y. (Ed.), Medicinal Protein Engineering, CRC Press 2008, pp. 277-297
 
20.      E.Alekseeva, I.Sominskaya, D.Skrastina, I.Egorova, E.Starodubova, E.Kushners, M.Mihailova, N.Petrakova, R.Bruvere, T.Kozlovskaya, M.Isaguliants, P.Pumpens. Enhancement of the expression of HCV core gene gives to enhancement to core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, proteins boost immunization regiment. Genetic Vaccines and Therapy, 2008, submitted.
 
21.      E.Alekseeva, I.Sominskaya, R.Bruvere, V.Ose, A.Zajakina, T.Kozlovska. Expression of hepatitis C virus structural genes controlled by alphaviral recombinant replicons. LU Raksti. Bioloģija, 2008., pieņemts publikācijai.
 
22.      F.Arša, S.Ņikišins, L.Lapke, J.Storoženko, O.Savicka, B.Rozentāle, V.Ķūse. C vīrushepatīta genotipi Latvijas iedzīvotājiem un to korelācija ar ārstēšanas kursa ilgumu. – LU Raksti Bioloģija lp.297.
 
23.      Pumpens P., Ulrich R., Sasnauskas K., Kazaks A., Ose V., Grens E. Construction of novel vaccines on the basis of the virus-like particles: Hepatitis B virus proteins as vaccine carriers, In: Y.Khudyakov (Ed.). Medicinal Protein Engineering. CRC Press, Taylor & Francis Group, Boca Raton London, New York, 2008, pp. 205-248.
 
24.      Kalnina Z, Silina K, Bruvere R, Gabruseva N, Stengrevics A, Barnikol-Watanabe S, Leja M, Line A. Molecular characterisation and expression analysis of SEREX-defined antigen NUCB2 in gastric epithelium, gastritis and  gastric cancer. Eur J Hisopathol, in press.
 
25.      Dekhtyar Yu, Kacanovska A, Mezinskis G, Pumpens P, Renhofa R.  Attenuation spectrum of self-assembled system: semiconductor and virus-like nanoparticles. Biomedical Engineering, Proceedings of International onference. Kaunas University of Technology. Technologija, Kaunas, 2008, pp. 169-171.
 
26.      Iņaškina I., Šteinbergs J., Vasiļjeva I., 2008, Jauna prenatālās diagnostikas metode Latvijā trisomiju riska noteikšanai. Latvijas Ārsts, 64-67.
27.      Lāce B., Vasiljeva I., Dundure I., Barkane B., Akota I., Krumina A., 2008, Is SNPs in MSX1 gene playing a role in the development of cleft palate (CP) or clef lip/palate (CLP)?, European Journal of Human Genetics 16: 330.,
28.      Vasiljeva, Z. Kovalova, S. Nikulshin, O. Nikolajeva and S.Lejniece, 2008, Coagulopathy with FVIII deficiency and bleeding in a female patient,  Haemophilia, 14 (Suppl. 2): 106.
 
29.      Rabe B, Delaleau M, Bischof A, Sominskaya I, Pumpens P, Cazenave C, Castroviejo M, Kann M. Nuclear entry of hepatitis b virus capsids involve disintegration to protein dimers followed by nuclear reassociation to capsids. J. Biol. Chem., 2008, prepared.
 
30.      Ranka R., Baumanis V. Cloning and expression of immunogenic proteins of Lyme disease pathogen, Borrelia burgdorferi. 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress. Kioto, Japāna. Abstracts, p. 203
31.      Ranka R., Brangulis K., Sondore V., Baumanis V. Recombinant BBK32 protein fragment in serodiagnosis of Lyme disease. FEBS jounal, 2008, v.275, S.1, p. 275.
 
32.      D.Pjanova, A.Molvens, L.Akseln, L.Engele, B.Streinerte, K.Azarjana and O.heisele. Identification of CDK4 R24H mutation-positive melanoma falily by analysis of early-onset melanoma patients in Latvia. Pieņemts publicēšanai: in  Melanoma Research, 2009.
33.      Ozolina S, Sinicka O,  Jankevics E, Inashkina I, Gorski B, Gronwald J, Lubinski J, Nasedkina T,    Fedorova O, Lyubchenko L, Tihomirova L. The 4154delA mutation carriers in the BRCA1 gene    share common ancestry.     Publicēts Familial Cancer. 2008 Dec 9. [Epub ahead of print]    PMID: 19067236
 
 
34.      Shastry A. Sedimbi SK, Rajalingam R, Nikitina Zake L, Rumba I, Wigzell H, Sanjeevi CB. Combination of KIR 2D and HLA-C1 (Asn80) confers susceptibility to type 1 diabetes in Latvians. Int J Immunogenet. 2008.Dec.35(6), pp439-46
 
 
35.      Inashkina I, Radovica I, Smeltere L, Vitols E, Jankevics E.  Case-control study of patients with essential tremor in Latvia. European Journal of Neurology. 15: 988-990.2008.
36.      Inashkina I, Radovica I, Smeltere L, Vitols E, Jankevics E.  An association between essential tremor and ETM2 locus in Latvian population. European Human Genetics Conference. May 31 – June 3, Barcelona, Spain. Abstracts. European Journal of Human Genetics Vol. 16:311.2008.
 
37.      Li G, Assudani DP, Line A, Cao F, Miles A, Rees RC and McArdle SEB. Identification of Metastasis Associated Antigen 1 (MTA1) by Serological Screening of Prostate Cancer cDNA Libraries. Open Biochem J. 2008; 2: 100–107.
38.      E. Salna, K. Siliņa, J. Šaripova, A. Linē, N. Sjakste. Kvercetīna un kemferola ietekme uz iNOS ekspresiju kontroles un LPS inducēta iekaisuma gadījumā Wistar līnijas žurku aknās. LU Akadēmiskajais apgāds „LU Raksti. Medicīna", Nr 735., 2008. gads
39.      Persson M., Tars K. &Liljas L. The capsid of the small RNA phage PRR1 is stabilized by metal ions. J.Mol.Biol. 2008. 383: 914-22.
40.      Plevka P., Tars K& Liljas L. Crystal packing of a bacteriophage MS2 coat protein mutant corresponds to octahedral particles. Protein Sci. 2008 10: 1731-9.
41.      Sominskaya I, Mihailova M, Jansons J, Legzdina D, Pumpens P, Arsha F, Keish J, Sondore V, Rozentale B, Viksna L. Epidemiological study of Hepatitis B virus genotypes in Latvia. 2008. Submitted to J.Clin.Microbiol.  
42.      Sendi H., Mehrab-Mohseni M., Shahraz S., Norder H., , Noorinayer B., Zali M.R., Pumpens P.,  Magnius L.O. CTL escape mutation of core protein are more frequent in strains of HBeAg negative patients with low viral load. 2008. Liver International, submitted.  
43.      Rabe B, Delaleau M, Bischof A, Sominskaya I, Pumpens P, Cazenave C, Castroviejo M, Kann M. Nuclear entry of hepatitis b virus capsids involve disintegration to protein dimers followed by nuclear reassociation to capsids. J. Biol. Chem., 2008, prepared.
44.      Dekhtyar Yu, Kachanovska A, Mezinskis G, Patmalnieks A, Pumpens P, Renhofa R. Self-assembled system of semiconductor and virus-like nanoparticles.  Functionalized Nanoscale Materials, Devices and Systems. Proceedingosf the NATO Advanced Study Institute on Functionalized Nanoscale Materials, Devices and Systems for Chem.-bio Sensors, Photonics, and Energy Generation and Storage, Sinaia, Romania, 4-15 June 007. Ed.: Vaseashta A, Mihailescu N. Springer, pp. 347-350.  
 
Patenti:
 
1.      Patent application 2008. 0292652 Virus-like particles comprising a fusion protein of the coat protein of AP 205 and an antigenic peptide. Renhofa R.,Pumpens P. Cielens I. & coworkers from Cytos Biotechnology
 
2.      Kazāks A., Freivalds J., Pumpēns P., Dišlers A. Rekombinants rauga Pichia pastoris celms cilvēka hepatīta B vīrusa (subtips ayw) nukleokapsīdu iegūšanai. Latvijas Republikas patents P-08-65 (02.10.2008 ekspertīzes lēmums).
 
 
3.      „Ekspresijas sistēma rekombinanto vīrusveidīgo daļiņu iegūšanai”; A.Dišlers, I. Sominska, A. Kazāks, I. Petrovskis, I. Zariņa. Patenta publikācijas datums: 20.02.2008. Pieteikuma datums: 13.12.2005. Numurs Nr. 13587.
 
4.      Tsimanis AY, Saripo A, Leonciks A , Kurbatska V, Rudevica Z. Human recombinant soluble CCR5 chemokine receptor. US Patent and and Trademark Office. Application No 61/065, Date 02/11/2008.
Discuss in forum
 
Date: 11.01.2008 at 15:13:35
   2007
PubMed referred papers 2007
 
Hegazy UM, Tars K, Hellman U, Mannervik B. Modulating Catalytic Activity by Unnatural Amino Acid Residues in a GSH-Binding Loop of GST P1-1. J Mol Biol. 2007 Dec 14;
 
Plevka P, Tars K, Zeltins A, Balke I, Truve E, Liljas L. The three-dimensional structure of ryegrass mottle virus at 2.9 A resolution. Virology. 2007 Dec 20;369(2):364-74. Epub 2007 Sep 19.
 
Kalnina I, Zvagule T, Gabruseva N, Kirilova J, Kurjane N, Bruvere R, Kesters A, Kizane G, Kirilovs G, Meirovics I. Structural Changes in Lymphocytes Membrane of Chernobyl Clean-up Workers from Latvia. J Fluoresc. 2007 Nov;17(6):633-8. Epub 2007 Oct 9.
 
Mandrika I, Prusis P, Yahorava S, Tars K, Wikberg JE.  QSAR of multiple mutated antibodies. J Mol Recognit. 2007 Mar-Apr;20(2):97-102.
 
Erenpreisa J, Cragg MS. Cancer: A matter of life cycle? Cell Biol Int. 2007 Sep 2; [Epub]
 
Erglis K, Wen Q, Ose V, Zeltins A, Sharipo A, Janmey PA, Cebers A. Dynamics of magnetotactic bacteria in a rotating magnetic field. Biophys J. 2007 Aug 15;93(4):1402-12. Epub 2007 May 25.
 
Vorreiter J, Leifer I, Rosler C, Jackevica L, Pumpens P, Nassal M. Monoclonal antibodies providing topological information on the DHBV core protein and avihepadnaviral nucleocapsid structure.
J Virol. 2007 Sep 19;
 
Tretjakovs P, Latkovskis G, Licis N, Juhnevica D, Jurka A, Bormane I, I Aivars J, Stifts A, Pirags V. Interleukin-6 gene promoter -174G/C polymorphism and insulin resistance: a pilot study. Clin Chem Lab Med. 2007;45(9):1145-8.
 
Juhna T, Birzniece D, Larsson S, Zulenkovs D, Sharipo A, Azevedo NF, Menard-Szczebara F, Castagnet S, Feliers C, Keevil CW. Detection of Escherichia coli in biofilms from pipe samples and coupons in drinking water distribution networks. Appl Environ Microbiol. 2007 Aug 24
 
Haitina T, Klovins J, Takahashi A, Lowgren M, Ringholm A, Enberg J, Kawauchi
H, Larson ET, Fredriksson R, Schioth HB. Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes.
BMC Evol Biol. 2007 Jun 29;7:101.
 
Pjanova D, Engele L, Randerson-Moor JA, Harland M, Bishop DT, Newton Bishop JA, Taylor C, Debniak T, Lubinski J, Kleina R, Heisele O. CDKN2A and CDK4 variants in Latvian melanoma patients: analysis of a clinic-based population. Melanoma Res. 2007 Jun;17(3):185-91.
 
Lagerstrom MC, Rabe N, Haitina T, Kalnina I, Hellstrom AR, Klovins J,
Kullander K, Schioth HB. The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal
cells. J Neurochem. 2007 Feb;100(4):1129-42.
 
Fridmanis D, Fredriksson R, Kapa I, Schioth HB, Klovins J. Formation of new genes explains lower intron density in mammalian Rhodopsin G protein-coupled receptors. Mol Phylogenet Evol. 2007 Jun;43(3):864-80. Epub 2006 Nov 17.
 
Braun S, Zajakina A, Aleksejeva J, Sharipo A, Bruvere R, Ose V, Pumpens P, Garoff H, Meisel H, Kozlovska T.  Proteasomal degradation of core protein variants from chronic hepatitis B patients.  
J Med Virol. 2007 Jul 2;79(9):1312-1321  
 
Skudra S, Stāka A, Puķītis A, Siņicka O, Pokrotnieks J, Nikitina M, Tracums J, Tihomirova L.
 Association of genetic variants with pancreatic cancer. Cancer Genet Cytogenet. 2007 Nov;179(1):76-8.  
 
Pjanova D, Engele L, Randerson-Moor JA, Harland M, Bishop DT, Newton Bishop JA, Taylor C, Debniak T, Lubinski J, Kleina R, Heisele O. CDKN2A and CDK4 variants in Latvian melanoma patients: analysis of a clinic-based population.Melanoma Res. 2007 Jun;17(3):185-91.
 
Cebers A, Erglis K, Wen Q, Ose V, Zeltins A, Sharipo A, Janmey P. Dynamics of magnetotactic bacteria in a rotating magnetic field. Biophys J. 2007 May 25; [Epub ahead of print]
 
Lagerstrom, M. C., Rabe, N., Haitina, T., Kalnina, I., Hellstrom, A. R., Klovins, J., Kullander, K., and Schioth, H. B. (2007) The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells, J Neurochem 100, 1129-1142.
 
Ling S, Li Z, Borschukova O, Xiao L, Pumpens P, Holoshitz J.  The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated anti-oxidative pathway. Arthritis Res Ther. 2007 Jan 25;9(1):R5  
 
Voronkova T, Kazaks A, Ose V, Ozel M, Scherneck S, Pumpens P, Ulrich R. Hamster polyomavirus-derived virus-like particles are able to transfer in vitro encapsidated plasmid DNA to mammalian cells. Virus Genes. 2007 Jun;34(3):303-14.
 
Balke I, Resevica G, Zeltins A. The Ryegrass mottle virus genome codes for a sobemovirus 3C-like serine protease and RNA-dependent RNA polymerase translated via -1 ribosomal
frameshifting. Virus Genes. 2007 Mar 14; PMID: 17356908 [PubMed - as supplied by publisher]
 
 
Conference/Meeting Theses
 
M. Koulikovska, P. Fagerholm. Effect of Biglycan on Interleukin 1-induced Apoptosis of Transformed keratocytes. 2007 ARVO Annual Meeting
 
B.Peebo Bourghardt, M.Koulikovska, P.Fagerholm. The Suppression of the Cell Adhesion Protein CEACAM1 by the Anti-Angiogenetic Aptamer Macugen® Is Dose Dependant. 2007 ARVO Annual Meeting
 
Koulikovska M, Sharipo A, Fagerholm P. Interleukin1-Induced apoptosis of keratocytes: effect of biglycan. 2007 EVER Annual Meeting.
 
Bourghardt Peebo B, Koulikovska M, Fagerholm P. The suppression of early angiogenic markers by the antiangiogenic aptamer Macugen® is dose dependent. 2007 EVER Annual Meeting.
Discuss in forum
 
Date: 20.03.2007 at 13:08:49
   2006
1.      Mihailova M, Boos M, Petrovskis I, Ose O, Skrastina D, Fiedler M, Sominskaya I, Ross S, Pumpens P,  Roggendorf M, Viazov S. Recombinant virus-like particles as a carrier of B- and T- cell epitopes of hepatitis C virus (HCV). Vaccine, 2006 May 15;24(20):4369-4377. Epub 2006 Mar 15.  
2.      Freivalds J, Dislers A, Ose V, Skrastina D, Cielens I, Pumpens P, Sasnauskas K, Kazaks A. Assembly of bacteriophage Qβ virus-like particles in yeast Saccharomyces cerevisiae and Pichia pastoris. J. Biotechnol., 2006 May 29;123(3):297-303. Epub 2006 Jan 6.  
3.      Voronkova T, Kazaks A, Ose V, Özel M, Scherneck S, Pumpens P, Ulrich R. Hamster polyomavirus-derived virus-like particles are able to transfer in vitro encapsidated plasmid DNA to mammalian cells. Virus Genes. 2006 Aug 22; [Epub ahead of print].  
4.      Sominskaya I, Alekseeva E, Skrastina D, Mokhonov V, Starodubova E, Jansons J, Levi M, Prilipov A, Kozlovska T, Smirnov V, Pumpens P, Isaguliants MG. Signal sequences modulate the immunogenic performance of human hepatitis C virus E2 gene. Mol Immunol. 2006 May;43(12):1941-1952. Epub 2006 Jan 25.  
5.      Mihailova M, Fiedler M, Boos M, Petrovskis I, Sominskaya I, Roggendorf M, Viazov S , Pumpens P. Preparation of hepatitis C virus structural and nonstructural protein fragments and studies of their immunogenicity. Protein Expr Purif. 2006 Nov;50(1):43-48. Epub 2006 Jun 27.  
6.      Ling S., Lai A., Borschukova O., Pumpens P., Holoshitz J.  Activation of nitric oxide signalling by the rheumatoid arthritis shared epitope. Arthritis Reum, 2006, 54(11):3423-3432.  
7.      Ling S., Li Z., Borschukova O., Xiao L., Pumpens P., Holoshitz J. The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated anti-oxidative pathway. Arthritis Reum., 2006, accepted for publication.  
8.      Kyuregyan K, Poleschuk V, Zamyatina N, Isaeva O, Mihailova M, Pumpens P, Michailov M, Roggendorf M, Viazov S. P.506 Experimental vaccination of marmosets against GBV-B infection.  Journal of Clinical Virology, Volume 36, Supplement 2, 2006, Page S217  
9.      Sendi H., Mehrab-Mohseni M., Norder H., Shahraz S., Noorinayer B., Zali M.R., Pumpens P.,  Magnius L.O. Mutations in the CTL epitope at residue 18-27 of HBcAg are more frequent in strains of HBeAg negative patients with low viral load. 2006, prepared for submission.  
10.      Braun S, Zajakina A, Alekseeva E, Sharipo A, Bruvere R, Meisel H, Pumpens P, Kozlovska T. Proteasomal degradation of HBV core protein from naturally occurring internally deleted core gene variants. J. Clin. Microbiol., 2006, submitted.  
11.      Ulrich R., Gedvilaite A., Kazaks A., Lomonossoff G., Sasnauskas K., Pumpens P. Virus-like particles: Tools for basic and applied research. Virus genes, prepared for submission.  
12.      Balmaks R., Freivalds J, Pumpēns P, Kazāks A.  Tumor-asociēto antigēnu inkorporācija vīrusveidīgās daļiņās. LU Raksti, 2006, pieņemts publicēšanai.
13.      Zvirbliene A, Samonskyte L, Gedvilaite A, Voronkova T, Ulrich R, Sasnauskas K. Generation of monoclonal antibodies of desired specificity using chimeric polyomavirus-derived virus-like particles.J Immunol Methods. 2006 Apr 20;311(1-2):57-70. Epub 2006 Feb 20.
14.      Licis N, van Duin J (2006) Structural constraints and mutational bias in the evolutionary restoration of a severe deletion in RNA phage MS2. J Mol Evol 63: 314-329.
15.      Līcis N, Krivmane B, Berzina M, Zabunova M, Latkovskis G (2006) A radical mutation in the GPIIIA gene of a patient with myocardial infarction. Proceedings of the Latvian Academy of Sciences. Section B, 60: 140-141.
16.      Juhnevica D, Tretjakovs P, Licis N, Jurka A, Berzina M, Zabunova M, Erglis A, Latkovskis G (2006) Interleukin-6 gene (-174) G/C polymorphism and insulin resistance in overweight patients with coronary heart disease. Seminars in Cardiology 12: 106-110.
17.      Latkovskis G, Licis N, Zabunova M, Berzina M, Juhnevica D, Erglis A. (2006) Association of interleukin-6 promoter haplotype with coronary artery occlusions. American Journal of Cardiology Supplement 98: 212M.
18.      Latkovskis G, Licis N, Zabunova M, Berzina M, Juhnevica D, Erglis A (2006). Association of a common interleukin-6 promoter haplotype with localization of coronary artery occlusions. Advances in Interventional Cardiology 4/6: 318-319.
19.      Latkovskis G, Licis N, Zabunova M, Berzina M, Erglis A (2006) Haplotypes of interleukin-6 promoter correlate with cholesterol levels in patients treated with statins. Atherosclerosis Supplements 7/3: 142.
20.      Brudey K, Driscoll JR, Rigouts L, Prodinger WM, Gori A, Al-Hajoj SA, Allix C, Aristimuno L, Arora J, Baumanis V, Binder L, Cafrune P, Cataldi A, Cheong S, Diel R, Ellermeier C, Evans JT, Fauville-Dufaux M, Ferdinand S, Garcia de Viedma D, Garzelli C, Gazzola L, Gomes HM, Guttierez MC, Hawkey PM, van Helden PD, Kadival GV, Kreiswirth BN, Kremer K, Kubin M, Kulkarni SP, Liens B, Lillebaek T, Ho ML, Martin C, Martin C, Mokrousov I, Narvskaia O, Ngeow YF, Naumann L, Niemann S, Parwati I, Rahim Z, Rasolofo-Razanamparany V, Rasolonavalona T, Rossetti ML, Rusch-Gerdes S, Sajduda A, Samper S, Shemyakin IG, Singh UB, Somoskovi A, Skuce RA, van Soolingen D, Streicher EM, Suffys PN, Tortoli E, Tracevska T, Vincent V, Victor TC, Warren RM, Yap SF, Zaman K, Portaels F, Rastogi N, Sola C. Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology.BMC Microbiol. 2006 Mar 6; p. 6-23.  
21.      Pliss L, Tambets K, Loogvali E, Pronina N, Lazdins M, Krumina A, Baumanis V, Villems R. Mitochondrial DNA portrait of Latvians: towards the understanding of the genetic structure of Baltic-speaking populations. Ann Hum Genet. 2006 Jul;70(Pt 4) 439-58.
22.      Pliss L.,Timsa L., Puzuka A., Pliss L., Krumina A.,  Baumanis V., Tambets K., Villems R. Phylogeorgaphy of mitochondrial and Y- chromosomal lineages and genetic structure of Latvians. 20th IUBMB International Congress of Biochemistry and Molecular Biology. Abstracts. 2006, Kyoto Japan, p. 198.
23.      Ranka R., Baumanis V. Expression of hypothetical B.garinii protein from erp gene family in E. coli. The FEBS Journal, 2006, v.273,S.1,p. 255
24.      Bauskenieks M., Nodieva A., Skenders G., Jansone I., Baumanis V. Genotypes of recurrent tuberculosis causing mycobacteria. The FEBS Journal, 2006, v.273,S.1, p.308
25.      Krumina A., Pliss L.,Lazdins M.,  Baumanis V.  Genetic relationship between Latvinas and neighbouring populations, revealed by mitichondrial analysis. The FEBS Journal, 2006, v.273,S.1,p.326
26.      Krumina A., Pliss L.,Zeltina A.,  Baumanis V.Mitochondrial genotypes  and heteroplasmy associated with  longevity in the Latvian population. 3rd International Conference on Functional Genomics of Ageing. Abstracts, 2006, Palermo Italy, p.23.
27.      Nodieva A., Jansone I., , Broka L., Skenders G. , Tracevska T.,  Baumanis V.  Recent transmission of drug resistant M. tuberculosis in Latvia European Respiratory Journal, 2005, v.26, S.49, p.701.
28.      Zirnitis A., Jansone I., Liepins E., Baumanis V. Characterisation of Mycobacterium avium isolated fromI veterinary sources in Latvia 27th Annual Congress of the European Society of Mycobacteriology,  2006, London, United Kingdom. Abstract.    
29.      Nodieva A., Broka L., Šķenders Ģ., Jansone I., Baumanis V. Multizāļu rezistentas tuberkulozes nozokomiālā transmisija.   Rīgas Stradiņa universitātes 2006.g. zinātniskās konferences tēzes, Rīga, 2006, 198 lpp.
30.      S. Lejniece, I. Vasiļjeva, H. Mikažāne, A. Lejnieks, 2003, Trombofilijas DNS diagnostikas iespējas Latvijā, Zraksti/RSU, 64-67
31.      .Lejniece S., Vasiljeva I., Zandberga E., Kovaljeva Z., DNA diagnostics of haemophilia A and B – problems and solutions in Latvia, 2004, 4th Baltic Conference of Haematology, abstract book, 65
32.      Lejniece S., Vasiljeva I., Zandberga E., Kovaljeva Z., Herrmann F., 2004, Screening of mutations causing Haemophilia A and B in Latvian population, 9th Annual Congress of the European Hematology Assotiacion, abstract book
33.      Lace B., Vasiljeva I., Barkane I., Akota I., Krumina A., 2006, Mutation analysis of the MSX1 gene exons and intron in patients with nonsyndromic clef lip and palate., Stomatplogija; 8(1): 21-24.
34.      Kalnina Z, Silina K, Meistare I, Zayakin P, Rivosh A, Abols A, Minenkova O, Schadendorf D, Line A. Evaluation of T7 and Lambda phage display systems for survey of autoantibody profiles in cancer patients. (manuscript in preparation)
35.      Kalnina Z, Silina K, Bruvere R, Stengrevics A, Line A. Expression analysis of a novel autoantigen NUCB2 in gastric epithelium, gastritis and gastric cancer. (manuscript in preparation)
36.      Linē A, Kalniņa Z, Gailīte I, Siliņa K, Rivosh A, Zayakin P, Pilāns D, Stengrēvics A. Evaluation of T7 phage display system for high-throughput analysis of the autoantibody repertoires in cancer patients. 19th Meeting of the European Association for Cancer Research, Budapest, Hungary, 2006, July1-5, Proceedings, p260.
37.      Kalniņa Z, Gailīte I, Siliņa K, Zayakin P, Rivosh A, Pilāns D, Pauniņa Z and Linē A. Characterisation of the repertoire of antigens identified using T7 Select phage display based SEREX approach. International Symposium of Immunogenomics and Immunomics. Budapest, Hungary, 2006, October 8-12
38.      Zayakin P, Kalniņa Z, Gailīte I, Siliņa K, Rivosh A, Pilāns D, Stengrēvics A, Linē A. Development of antigen microarray for analysis of the autoantibody repertoires in cancer patients. HHMI course on Modern Technologies on Gene Expression Detection and Data Integration, Debrecen, Hungary, 2006, July 18-26.  
39.      O.E.Fedorova, O.N.Sinicka, L.P.Tihomirova, Ya.V.Vishnevskaya,  A.S.Zasedatelev, T.V.Nasedkina. Analysis of Point Mutations of the BRCA1 gene by Hybridization with Hydrogel Microarrays. Molecular Biology, 2006; 40:25-29.  
40.      A.Stāka, S.Skudra, A.Puķītis, J.Pokrotnieks, L.Tihomirova. Assessment of Risk factors in the development of pancreatic cancer in Latvia. Acta Universitatis Latviensis, 2006, 000, Biology, p.41-51.  
41.      Hamel N,  Foretova L, Narod SA, Tihomirova L, Zajac V, Ciernikova S, Armaou S, Yannoukakos D, Greenwood C, Foulkes WD. Investigating the origins of the BRCA! mutation c.5385dupC.  Abstracts of Annual meeting of American Association of Human Genetics, 1040, 203, 2006.
42.      Kalnina, , R.Bruvere, T. Zvagule, N. Gabruseva, Ā.Volrāte, G. Feldmane, L. Klimkāne, J. Kirilova, I. Meirovics. Immune state of patients with different pathologies monitored by fluorescent probe 3-aminobenzanthtone derivative.  Review. Procidings of the Latvian Academy of Sciences Section B: natural, exact, and applied sciences. 2006 Vol 60, N 4:113-120.
43.      Aina Muceniece, Rūta Brūvere, Guna Feldmane, Dita Venskus. Metodiskas norādes biopreparātu RIGVIR un LARIFĀNS lietošanai onkoloģijā un sekundāro imūndeficītu prefilaksei (vadoties no teorētiskām atziņām pasaules literatūrā un 40 gadus ilgas klīniskās pieredzes Latvijā). Brošūra. Rīga 2006, 24 lpp.
44.      Fridmanis, D., Fredriksson, R., Kapa, I., Schioth, H. B., and Klovins, J. (2006) Formation of new genes explains lower intron density in mammalian Rhodopsin G protein-coupled receptors, Mol Phylogenet Evol.
45.      Kalejs M, Ivanov A, Plakhins G, Cragg MS, Emzinsh Dz, Illidge TM, Erenpreisa Je (2006).  Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe. BMC Cancer  6:6 doi:10.1186/1471-2407-6-6.
 
International Symposia
1.      Mihailova M, Boos M, Petrovskis I, Ose O, Skrastina D, Fiedler M, Sominskaya I, Ross S, Pumpens P,  Roggendorf M, Viazov S. Recombinant virus-like particles as a carrier of B- and T- cell epitopes of hepatitis C virus (HCV). Vaccine, 2006 May 15;24(20):4369-4377. Epub 2006 Mar 15.  
2.      Freivalds J, Dislers A, Ose V, Skrastina D, Cielens I, Pumpens P, Sasnauskas K, Kazaks A. Assembly of bacteriophage Qβ virus-like particles in yeast Saccharomyces cerevisiae and Pichia pastoris. J. Biotechnol., 2006 May 29;123(3):297-303. Epub 2006 Jan 6.  
3.      Voronkova T, Kazaks A, Ose V, Özel M, Scherneck S, Pumpens P, Ulrich R. Hamster polyomavirus-derived virus-like particles are able to transfer in vitro encapsidated plasmid DNA to mammalian cells. Virus Genes. 2006 Aug 22; [Epub ahead of print].  
4.      Sominskaya I, Alekseeva E, Skrastina D, Mokhonov V, Starodubova E, Jansons J, Levi M, Prilipov A, Kozlovska T, Smirnov V, Pumpens P, Isaguliants MG. Signal sequences modulate the immunogenic performance of human hepatitis C virus E2 gene. Mol Immunol. 2006 May;43(12):1941-1952. Epub 2006 Jan 25.  
5.      Mihailova M, Fiedler M, Boos M, Petrovskis I, Sominskaya I, Roggendorf M, Viazov S , Pumpens P. Preparation of hepatitis C virus structural and nonstructural protein fragments and studies of their immunogenicity. Protein Expr Purif. 2006 Nov;50(1):43-48. Epub 2006 Jun 27.  
6.      Ling S., Lai A., Borschukova O., Pumpens P., Holoshitz J.  Activation of nitric oxide signalling by the rheumatoid arthritis shared epitope. Arthritis Reum, 2006, 54(11):3423-3432.  
7.      Ling S., Li Z., Borschukova O., Xiao L., Pumpens P., Holoshitz J. The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated anti-oxidative pathway. Arthritis Reum., 2006, accepted for publication.  
8.      Kyuregyan K, Poleschuk V, Zamyatina N, Isaeva O, Mihailova M, Pumpens P, Michailov M, Roggendorf M, Viazov S. P.506 Experimental vaccination of marmosets against GBV-B infection.  Journal of Clinical Virology, Volume 36, Supplement 2, 2006, Page S217  
9.      Sendi H., Mehrab-Mohseni M., Norder H., Shahraz S., Noorinayer B., Zali M.R., Pumpens P.,  Magnius L.O. Mutations in the CTL epitope at residue 18-27 of HBcAg are more frequent in strains of HBeAg negative patients with low viral load. 2006, prepared for submission.  
10.      Braun S, Zajakina A, Alekseeva E, Sharipo A, Bruvere R, Meisel H, Pumpens P, Kozlovska T. Proteasomal degradation of HBV core protein from naturally occurring internally deleted core gene variants. J. Clin. Microbiol., 2006, submitted.  
11.      Ulrich R., Gedvilaite A., Kazaks A., Lomonossoff G., Sasnauskas K., Pumpens P. Virus-like particles: Tools for basic and applied research. Virus genes, prepared for submission.  
12.      Balmaks R., Freivalds J, Pumpēns P, Kazāks A.  Tumor-asociēto antigēnu inkorporācija vīrusveidīgās daļiņās. LU Raksti, 2006, pieņemts publicēšanai.
13.      Zvirbliene A, Samonskyte L, Gedvilaite A, Voronkova T, Ulrich R, Sasnauskas K. Generation of monoclonal antibodies of desired specificity using chimeric polyomavirus-derived virus-like particles.J Immunol Methods. 2006 Apr 20;311(1-2):57-70. Epub 2006 Feb 20.
14.      Licis N, van Duin J (2006) Structural constraints and mutational bias in the evolutionary restoration of a severe deletion in RNA phage MS2. J Mol Evol 63: 314-329.
15.      Līcis N, Krivmane B, Berzina M, Zabunova M, Latkovskis G (2006) A radical mutation in the GPIIIA gene of a patient with myocardial infarction. Proceedings of the Latvian Academy of Sciences. Section B, 60: 140-141.
16.      Juhnevica D, Tretjakovs P, Licis N, Jurka A, Berzina M, Zabunova M, Erglis A, Latkovskis G (2006) Interleukin-6 gene (-174) G/C polymorphism and insulin re
Discuss in forum
 
Date: 20.03.2007 at 12:57:13
   2005
1.      Sominskaya I., Mihailova M., Jansons J., Emelyanova V., Folkmane I., Shmagris  E., Dumpis U., Rozentals R., Pumpens P. Hepatitis B and C viruses in long-term   immunosuppressed renal transplantation patients in Latvia. Intervirology, 48, 192-200, 2005.  
2.      Geldmacher A., Skrastina D., Petrovskis I., Borisova G., Kruger D.H., Pumpens P., Ulrich R. A hantavirus nucleocapsid protein segment presented on hepatitis B virus core particles is highly immunogenic in mice when applied without adjuvants and in the presence of preexsting antibodies against core. Vaccine, 23, 3973-3983, 2005.  
3.      Ling S., Lai A., Borschukova O., Pumpens P., Holoshitz J. Activation of a prooxidative signal transduction pathway by the rheumatoid arthritis shared epitope. Nature medicine, 2005, submitted.
4.      Ulrich R., Gedvilaine A., Kazaks A., Lomonossoff G., Sasnauskas K., Pumpens P. Virus-like particles: Tools for basic and applied research.Virus genes, prepared for submission.
5.      Balmaks R., Freivalds J., Pumpēns P., Kazāks A. Tumor-asociēto antigānu inkorporācija vīrusveidīgās daļiņās. Iesniegts LU Raksti, pieņemts 2005.
6.      Schwarz K., Meijerink E., Speiser DE, Tissot AC, Cielens I., Renhof R., Dishlers A., Pumpens P., Bachmann MF. Efficient homologous prime-boost strategies for T cell vaccination based on virus-like particles. Eur j. Immunol. 2005; 35(3);816-821.
7.      Freivalds J., Dislers A., Ose V., Skrastina D., Cielens I., Pumpens P., Sasnauskas K., Kazaks A. Assembly of bacteriophage Qb birus-like particles in yeast  Saccharomuces cerevisiae and Pichia pastoris. J.Biotechnol., 2005, accepted.
8.      Mihailova M, Boos M, Petrovskis I, Ose O, Skrastina D, Fiedler M, Sominskaya I, Baumert T, Ross S, Khudyakov Y, Pumpens P, Roggendorf M, Viazov S. Recombinant virus-like particles as a carrier of B-and T-cell epitopes of hepatitis c virus (HCV). J.Gen.Virol., prepared for submission.
9.      Voronkova T., Kazaks A., OseV., Ozel M, Scherneck S., Pumpens P., Ulrich R. Hamster polyomavirus-derived virus-like particles are able to transfer in vitro encapsidated plasmid DNA to mammalian cells. Virus genes, 2005, submitted.
10.      Braun S., Zajakina A., Alekseeva E., Sharipo A., Bruvere R., Meisel H., Pumpens P., Kozlovska T. Proteasomal degradation of HBV core protein from naturally occurring internally deleted core gene variants.J.Gen.Virol., prepared for submittion.
11.      Shestakova i., Domrecheva I., Shkutele S, Ose-Klinklava V.,Renhofa R. interaction of mosaic virus-like particles carrying HBV preSsequences with cell surface in cultures: Do these epitopes work as specific addresses? Cell Biology international, 29, 1110-1111,34-P3, 2005.
12.      Shkutele S., Cielens I., Skrastina D., Renhofa R.development of mosaic virus-like particles on base of RNA phase Qb coat and HBV preS sequences. Cell Biology international, 29, 1111, 35-P3, 2005.
13.      Zvirbliene A., Samonskyte L., Gedvilaite A., Voronkova T., Ulrich R., Sasnauskas K. Generation of monoclonal antibodies of desired specificity using chimeric polyomavirus-derived virus- like particles. I.Immunol. methods.Accepted.
14.      Kalejs M., Erenpreisa Je. Cancer/testis antigenes and ploidy cycles. A review with brain storming. Cancer Cell Int 2005, 5:4(online).
15.      Erenpreisa Je., Kalejs M., Ianzini F, Kosmacek EA, Mackey MA, Emzinsh D, Cragg MS, Ivanov A, Illidge TM. Segregation of genomes in polyploid tumour cells following mitotic catastrophe. Cell Biol. Int, 2005, 29:1005-1011.
16.      Erenpreisa Je, kalejs M, Cragg M. Mitotic catastrophe and endomitosis in tumour cell: An evolutionary key to a molecular solution. Cell Biol.Int 2005, 29: 1012-1018.
17.      Erenpreisa Je. And Wheatley D. endopolyploidy in development and cancer; “survival of the fattest “. Cell Biol Int.,2005, 29:981-982.
18.      Kalejs M, Ivanov A, Plakhins G, Cragg MS, Emzins Dz, Illidge TM, Erenpreisa Je. Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and the induction of mitotic catastrophe. BMC Cancer, 2005, accepted.
19.      Sominskaya I, Alekseeva E, Skrastina D, Mokhonov V, Starodubova E, Jansons J, Levi M, Prilipov A, Kozlovska T, Smirnov V, Pumpens P, Isaguliants M. Signal Sequences Modulate the Immunogenic performance of Human Hepatitis C virus E2 Gene. Molecular Immunology, 2005, accepted.  
20.      Kalnina Z., Silina K., Zajakin P., Line A. Alterations of pre-mRNA splicing in cancer. Genes, Cromosomes&Cancer, 42(4):342-57, 2005
21.      Haitina, T., Klovins, J., and Schioth, H. B. (2005) Pharmacological characterization of melanocortin receptors in fish suggests an important role for ACTH, Ann N Y Acad Sci 1040, 337-339.
22.      Klovins, J., and Schioth, H. B. (2005) Agouti-related proteins (AGRPs) and agouti-signaling peptide (ASIP) in fish and chicken, Ann N Y Acad Sci 1040, 363-367.
23.      Lagerstrom, M. C., Fredriksson, R., Bjarnadottir, T. K., Fridmanis, D., Holmquist, T., Andersson, J., Yan, Y. L., Raudsepp, T., Zoorob, R., Kukkonen, J. P., Lundin, L. G., Klovins, J., Chowdhary, B. P., Postlethwait, J. H., and Schioth, H. B. (2005) Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution, Genomics 85, 688-703.
24.      Petrovska, R., Kapa, I., Klovins, J., Schioth, H. B., and Uhlen, S. (2005) Addition of a signal peptide sequence to the alpha1D-adrenoceptor gene increases the density of receptors, as determined by [3H]-prazosin binding in the membranes, Br J Pharmacol 144, 651-659.
25.      Schioth, H. B., Haitina, T., Fridmanis, D., and Klovins, J. (2005) Unusual genomic structure: melanocortin receptors in Fugu, Ann N Y Acad Sci 1040, 460-463.
26.      Schioth, H. B., Haitina, T., Ling, M. K., Ringholm, A., Fredriksson, R., Cerda-Reverter, J. M., and Klovins, J. (2005) Evolutionary conservation of the structural, pharmacological, and genomic characteristics of the melanocortin receptor subtypes, Peptides 26, 1886-1900.
27. Koulikovska M, Podskochy A, Fagerholm P.
 The expression pattern of the subunit of chaperonin containing T-complex
polypeptide 1 and its substrate, alpha-smooth muscle actin, during corneal wound
healing.
Acta Ophthalmol Scand. 2005 Oct;83(5):543-8.
 
 
Discuss in forum
 
Date: 20.03.2007 at 12:51:12
   2004
1.      Andris Kazaks, Galina Borisova, Svetlana Cvetkova, Larisa Kovalevska, Velta Ose, Irina Sominskaya, Paul Pumpens, Dace Skrastina, Andris Dishlers.Mosaic hepatitis B core particles presenting complete preS sequence of viral envelope on their surface. Iesniegts žurnālam J.Gen. Virol.  
2.      Klovins J, Haitina T, Fridmanis D, Kilianova Z, Kapa I, Fredriksson R,Gallo-Payet N, Schioth HB . The Melanocortin System in Fugu: Determination of POMC/AGRP/MCR Gene Repertoire and Synteny, as Well as Pharmacology and Anatomical Distribution of the MCRs. Mol Biol Evol. 21, 563-579,2004.
3.      Kazaks A., Borisova G., Cvetkova S., Kovalevska L., Ose V., Sominskaya I., Pumpens P., Skrastina D., Dishlers A. Mosaic hepatitis B core particles presenting complete preS sequence of viral envelope on their surface. J.Gen.Virol., in print, 2004.
4.      Geldmacher A., Skrastina D., Petrovskis I., Borisova G., Berriman J.A., Roseman A.M.,Crowther R.A., Fischer J., Musema S., Gelderblom H.R., Renhofa R., Ose V., Kruger D.H., Pumpens P., Ulrich R. An amino-terminal segment of hantavirus nucleocapsid protein presented on hepatitis B virus core particles induces a strong and highly crossreactive antibody response in mice. Virology, in print, 2004.
5.      Sominskaya I., Mihailova M., Jansons J., Emelyanova V., Folkmane I., Shmagris E., Dumpis U., Rozentals R., Pumpens P. Variants of hepatitis B and C viruses in long-term immunosuppressed renal transplantation patients. Intervirology, submitted, 2004.
6.      Bruvere R., Braun S., zajakina A., Aleksejeva E., Sharipo A., Meisel H., Pumpens P., Kozlovska T.Subcellular localisation of internally deleted HBV core proteins. Acta Universitatis Latviensis, 2004., submitted.
7.      Kozlovsaka T., Zajakina A., Ose V., Bruvere R., Aleksejeva J., Pumpens P., Garoff H. Synthesis of all Hepatitis B structural proteins in Semliki Forest virus expression system. Acta Universitatis Latviensis, 2004, submitted.  
8.      Haitina, T., Klovins, J., Andersson, J., Fredriksson, R., Lagerstrom, M. C., Larhammar, D., Larson, E. T., and Schioth, H. B. (2004) Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes, Biochem J 380, 475-486.
9.      Klovins, J., Haitina, T., Ringholm, A., Lowgren, M., Fridmanis, D., Slaidina, M., Stier, S., and Schioth, H. B. (2004) Cloning of two melanocortin (MC) receptors in spiny dogfish: MC3 receptor in cartilaginous fish shows high affinity to ACTH-derived peptides while it has lower preference to gamma-MSH, Eur J Biochem 271, 4320-4331.
10.      Ringholm, A., Klovins, J., Rudzish, R., Phillips, S., Rees, J. L., and Schioth, H. B. (2004) Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair, J Invest Dermatol 123, 917-923.
11. Podskochy A, Koulikovska M, Fagerholm P, van der Ploeg I.  Biglycan gene expression in UVR-exposed rabbit corneas. Acta Ophthalmol Scand. 2004 Apr;82(2):200-4.
12. Pintacuda G, Moshref A, Leonchiks A, Sharipo A, Otting G.
 Site-specific labelling with a metal chelator for protein-structure refinement.
J Biomol NMR. 2004 Jul;29(3):351-61.
13. Zajakina A, Kozlovska T, Bruvere R, Aleksejeva J, Pumpens P, Garoff H.
 Translation of hepatitis B virus (HBV) surface proteins from the HBV pregenome
and precore RNAs in Semliki Forest virus-driven expression. J Gen Virol. 2004 Nov;85(Pt 11):3343-51.  
 
 
 
Discuss in forum
 
Date: 20.03.2007 at 12:49:34
   2003
1.      Lazdina U., Alheim M., Nyström J., Hultgren C., Borisova G., Sominskaya I.,Pumpens P., Peterson D.L., Milich D.R., Sallberg M. Priming of cytotoxic T cell responses to exogenous hepatitis B core antigen (HBcAg) is B cell dependent.2003. J.Gen.Virol, 84:139-146.
2.      Dumpis U., Kovaļova Ž., Jansons J., Čupāne L., Sominskaya I., Michailova M.,Karayiannis P., Gardovska D., Viazov S., Ross S. , Roggendorf M., Pumpens P. An outbreak  of HBV and HCV infections in a paediatric oncology ward:Epidemiological investigations and prevention of further spread. J. Med. Virol., 2003.VOL 69: 331-338.
3.      41. Tars K., Zeltins A., Liljas L. The three-dimensional structure of cocksfoot mottle virus at 2.7  resolution. Virology 310, 287-297.  2003.
4.      Kazaks A, Dishlers A, Pumpens P, Ulrich R, Kruger DH, Meisel H Mosaic particles formed by wild-type hepatitis B virus core protein and its deletion variants consist of both homo- and heterodimers. FEBS Lett 2003 Aug 14 549:1-3 157-62  
5.      Lagerstrom MC, Klovins J, Fredriksson R, Fridmanis D, Haitina T, Ling MK, Berglund MM, Schioth HB. High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3. J Biol Chem. Dec 19; 278(51): 51521-6. 2003.
6.      Ringholm A., Klovins J., Fredriksson R., Poliakova N., Larson E.T. Kukkonen J.P.,Larhammar D., & Schioth H.B. Presence of melanocortin (MC4) receptor in spiny dogfish  suggests an ancient vertebrate origin of central melanocortin system. Eur. J. Biochem. 270, 213-221,2003.
7.      Schioth HB, Lagerstrom MC, Watanobe H, Jonsson L, Vergoni AV, Ringholm A, Skarphedinsson JO, Skuladottir GV, Klovins J and Fredriksson R. Functional role, structure, and evolution of the melanocortin-4 receptor. Ann N Y Acad Sci. 994:74-83, 2003.
 
8.      Aneta Ringholm, Janis Klovins, Robert Fredriksson, Natalia Poliakova, Earl T. Larson,  Jyrki P. Kukkonen, Dan Larhammar and Helgi B. Schioth, Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system. Eur.J. Biochem., 270, 1-9,2003.
9.      Tars K., Zeltins A., Lars Liljas. The three-dimensional structure of Cocksfoot Mottle virus 27 A resolution.   Virology, Vol. 310, 287-297,2003.
 
10.      Baumanis V., Jansone I., Broka L., Nodieva A., Bratkovskis M., Tracevska T., Evaluation of the insertion sequence-6110-based polymerase chain reaction for detection of  pathogenic mucobacteria. Acta Universitatis, Latviensis,Vol 662,17-24, 2003.
 
11.      Baumanis V., Jansone I., Tracevska T., Puzuka A., Skipars V., Chapligina V., Broka L., Nodieva A. Evaluation of the insertion sequence-6110-based polymerase chain reaction for detection of  pathogenic mucobacteria. The International Journal of Tuberculosis and Lung Disease. Vol. 7, Nr.11.,202-203, 2003.  
 
12.      Tracevska T.,Jansone I., Baumanis V., Marga O., Lillebaek T. Prevalence of Beijing genotype in Latvian multidrug-resistant Mycobacterium tuberculosis isolates. The International Journal of tuberculosis and Lung Disease. Vol. 7., Nr.11, 1097-1103., 2003.
13.      Bormane A., Lucenko I., Duks A., Mavchoutko V., Ranka R., Salmina K., Baumanis V. Vectors of tick-borne diseases and epidemiological situation in Latvia in 1993-2002. International Journal of Medical Microbiology. Vol 293, 36-47, 2003.
14.      Ranka R., Salmina Kzygutiene M., Morkunas B., Bormane A.,  Baumanis V. Prevalence of varios Borrelia burgdorferi sensu lato species in Ixodes ticks in three Baltic countries. Acta Universitatis Latviensis, Vol.662, 7-15, 2003.
15.      Pliss L., Krumina A., Baumanis V., Pronina N., Lazdins M. The involvement of the human mitochondrial DNA in ageing process. Journal of FEBS, IUBMB, NATO Advanced Research Workshop: “Frontiers in neurogenerative disorders and aging: fundamental aspects, clinical perspectives and new insights”. 112, 2003.
16.      Dumpis U., Kovalova Z.,Jansons J., Cupane L., Sominskaya I., Michailova M., Karayiannis P., Gardovska D., Viazov S., Ross S., Roggendorf M., Pumpens P. An outbreak of HBV and HCV infestion in a paesiatric oncology ward: Epidemiological investigations and prevention of further spread. J.Med. Virol.Vol.69, 331-338, 2003.
17.      Lazdina U., Alheim M., Nystrom J., Hultgren C., Borisova G., Sominskaya I., Pumpens P., Peterson D.L., Milich D.R., Sallberg M. Ptiming of cytotoxic Tcell responses to exogenous hepatitis B core antigen is B cell dependet. J. Gen. Virol., Vol 84, 139-146.
18.      Mihailova M., Sominskaya I., Jansons J., Rozentals R., Pumpens P. Structural features  of hepatitis B virus from longterm immunosuppressed patients in Latvia. Proc. Latv. Acad. Science, Vol.57, 158-163, 2003.
19.      Kazaks A., Dishlers A., Pumpens P., Ulrich R., Kruger D.H., Meisel H. Mosaic particles formed by wild-type HBV core protein and its deletion variants consist of both homo-and heterodimers. FEBS Letters, 549, 157-162, 2003.
20.      Erenpreisa J., ErenpreissJ., Freivalds T., Slaidina M., Krampe R., Butikova J., Ivanov A., Pjanova D. Toluidine blue test for sperm DNA integrity and elaboration of image cytometry algorithm. Cytometry, 52A, 19-27, 2003.
21.      Ivanov A., Cragg M.S., Erenpreisa Je., Emzinsh D., Lukman H., Illidge T. Endopolyploid tumour cells producted after severe  genotoxic damage have the potential to repair DNA double strand breaks. J.Cell Sci. 116, 4095-4106, 2003.
22.      Pjanova D., Heisele O., Engele L., Desjatnikova I. Tumour suppressor gene CDKN2A/p16 germline mutations in melanoma patgients with additional cancer in their family history. Acta Universitatis Latviensis nv.662, 25-32, 2003.
23.      Heisele O., Pjanova D., Iedzimtība un slimības, Doctus, novembris, 46-48, 2003.
24.      Pjanova D., Heisele O., Engele L., Desjatnikova I. Tumour suppressor gene CDKN2A variants inmelanoma patients of Latvian population. Pigment Cell Res.vol.16, Nr.5, 599,2003.
25.      Pjanova D., Heisele O., Engele L., Desjatnikova I. Screening for tumour suppressor gene CDKN2A  germline mutations with melanoma and unrelated cancer in family history. Third Research Meeting on melanoma.51, 2003.
26.      Erenpreisa J., Ivanov A. Cragg M.S. Illidge T.M. The enents of mitotic catastrophe are caused after genotoxic stree in lymphoid tumour cells by activation of Mos/MAPK pathway. Proceed.Intern. Conf.on Applied Genomics, Amsterdam, Abstr.E-20, 88, 2003.
27.      Ivanov A., Cragg M., Erenpreisa J., Illidge T. Radiation-induced MAPK activation produces polyploid tumour cells that undergo DNA double strand break repair. British Journal of Cancer 88, S26-S26,2003.
28.      Liepinsh E., Barbals R., Dahl E., Sharipo A., Staub E., Otting G. The death-domain fols of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN reconition. Journal Molecular Biology, October 3, 332, 1155-1163, 2003.
29.      Liepinsh E., Leonchiks A., Sharipo A., Guignard L., Otting G. Solution structure of the R3H domain form human Smubp-2. Journal Molecular Biology, February 7, 326(1), 217-223, 2003.
30.      Bruvere R., Gabruseva N., Volrate A., Heisele O., Feldmane G., Zvagule T., Balodis V. Functional defienciency of the immune system of chernobyl accident clean-up workers residing in Latvia. Proc. Latvian Acad. Sci. section B,  vol.57, Nr.1/2, pp17-21, 2003.
31.      Bruvere R., Gabruseva N., kalnina I., Feldmane G., Meirovics I. Fluorescent characteristics of blood leukocytes of patients with Malignant and non-malignant diseases. J.of Fruorescence, vol.13, Nr.2, pp 149-156, 2003.
32.      Kalnina I., Bruvere R., Gabruseva N., Zvagule T., Heisele O., Volrate A. Feldmane G., Meirovics I. Phenotypical characteristics of leikocytes of Chernobyl clean-uo workers from Latvia: use of fluorescent probe ABM.-Биологические мембраны, 2003, том 20, Nr.6, с.506-512.
33.      Ringholm, A., Klovins, J., Fredriksson, R., Poliakova, N., Larson, E. T., Kukkonen, J. P., Larhammar, D., and Schioth, H. B. (2003) Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system, Eur J Biochem 270, 213-221.
34.      Schioth, H. B., Lagerstrom, M. C., Watanobe, H., Jonsson, L., Vergoni, A. V., Ringholm, A., Skarphedinsson, J. O., Skuladottir, G. V., Klovins, J., and Fredriksson, R. (2003) Functional role, structure, and evolution of the melanocortin-4 receptor, Ann N Y Acad Sci 994, 74-83.
Discuss in forum
 
Date: 20.03.2007 at 12:47:24
   2002
1.      Jankevica L., Kropa M., Savenkovs N., Jankevics E. Presence of nucleopolyhedroviruses in natural populations of Malacosoma neustria L. (Lepidoptera, Lasiocampidae) .2002., Latvijas Entomologs 39: 30-36.
2.      Chuvpilo S., Jankevics E., Tyrsin D., Akimzhanov A., Moroz D., Kupar Jha M., Schulze-Luehrmann J., Santner-Nanan B., Feoktistova E., Koning T., Avots A., Schmitt E., Berberich-Siebelt F., Schimpl A., Serfling E. Autoregulation of NFATc1/A Expression Facilitates Effector T Cells to Escape from Rapid Apoptosis.2002., Immunity vol 16, 881-895.
3.      Leonchiks A, Stavropoulou V, Sharipo A, Masucci MG. Inhibition of ubiquitin-dependent proteolysis by a synthetic glycine-alanine repeat peptide that mimics an inhibitory viral sequence. FEBS Lett. 2002 Jul 3; 522 (1-3):93-8.
4.      Sargsyan E, Baryshev M, Backlund M, Sharipo A, Mkrtchian S. Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29. Gene. 2002 Feb 20; 285 (1-2):127-39.
5.      Li L, Sharipo A, Chaves-Olarte E, Masucci MG, Levitsky V, Thelestam M, Frisan T. The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non- proliferating cells. Cell Microbiol. 2002 Feb;4 (2):87-99.
6.      Sargsyan E, Baryshev M, Szekely L, Sharipo A, Mkrtchian S. Identification of ERp29, an endoplasmic reticulum lumenal protein, as a new member of the thyroglobulin folding complex. J Biol Chem. 2002 May 10; 277(19):17009-15.
7.      Heessen S, Leonchiks A, Issaeva N, Sharipo A, Selivanova G, Masucci MG, Dantuma NP. Functional p53 chimeras containing the Epstein-Barr virus Gly-  Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis. Proc Natl Acad Sci. U S A. 2002 Feb 5; 99(3):1532-7.
8.      Williams NK, Prosselkov P, Liepinsh E, Line I, Sharipo A, Littler DR, Curmi PM, Otting G, Dixon NE. In vivo protein cyclization promoted by a circularly permuted Synechocystis sp. PCC6803 DnaB mini-intein. J Biol Chem. 2002 Mar 8;277(10):7790-8.
9.      Eglītis, A.Stengrevics, L.Tihomirova. Krūts vēža ģenētiskie aspekti. Latvijas Ārsts. 2002. novembris, lp.17.-21.
10.      Sominskaya I., Paulij  W., Jansons J., Sobotta D., Dreilina D. , Sunnen C., Meisel H., Gerlich W.H., Pumpens P. Fine-mapping of the B-cell Epitope Domain at the N-terminus of the preS2 Region of the Hepatitis B Surface Antigen. 2002. J. Immunol. Meth., 260, 251-261.
11.      Pumpens P., Razanskas R., Pushko P., Renhof R., Gusars I., Skrastina D., Ose V., Borisova G., Sominskaya I.,  Petrovskis I., Jansons J, Sasnauskas K. Evaluation of HBs, HBc, and frCP virus-like particles for expression of human papillomavirus 16 E7 oncoprotein  epitopes. Intervirology, 2002;45(1):24-32.
12.      Pumpens P, Grens E. Artificial genes for chimeric virus-like particles. In: Artificial DNA: Methods and Applications. CRC Press LLC, Boca Raton, 2002, pp. 249-327.
13.      Pumpens P., Grens E., Nassal M. Molecular epidemiology and immunology of hepatitis B virus infection. Intervirology, 2002, 45, N 4-6, 218-232.  
14.      Kazaks A., Lachmann S., Koletzki D., Petrovskis I., Dislers A., Ose V., Skrastina D., Gelderblom H.R., Lundkvist A., Meisel H., Borisova G., Krüger D.H.,  
15.      Pumpens P., Ulrich R. Stop-codon insertion restores the particle formation ability of hepatitis B virus core/hantavirus nucleocapsid protein fusions. Intervirology, 2002, 45, N 4-6, 340-349.  
16.      Voronkova T., Grosch A., Kazaks A., Ose V., Skrastina D., Sasnauskas K., Jandrig B., Arnold W., Scherneck S., Pumpens P., Ulrich R. Chimeric bacteriophage fr virus-like particles harboring the immunodominant C-terminal region of hamster polyomavirus VP1  induce a strong VP1-specific antibody response in mice. Viral Immunol , 2002, 15, N 4, 627-643.  
17.      Jegerlehner A, Tissot A, Lechner F, Sebbel P, Erdmann I, Kundig T, Bachi T, Storni T, Jennings G, Pumpens P, Renner W, Bachmann M. A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses. Vaccine 2002, 20(25-26): 3104-3112.  
18.      Jegerlehner A., Storni T., Lipowsky G., Schmid M., Pumpens P., Bachmann  M.F. Regulation of IgG antibody responses by epitope density and CD21-mediated costimulation. Eur. J. Immunol. 2002. 32: 3305–3314.
19.      R. Bruvere, O. Heisele, A. Ferdats, A. Rupais, A. Mucenice. Echovirus-mediated biotherapy for malignant tumours: 40 years of invesigation. Acta Medica Lituanica, 2002, suppl. 9, 97-100.
20.      T.Zvagule, R.Bruvere, N.Gabruševa, V.Balodis, G.Feldmane. Health problems shown by clinical and immunological tests in Chernobyl clean-up workers during the 15-year period (1986-2000). Latvian Acad. Sci. Section B, 2002, vol 56, N 6, pp248-253.
21.      T.Zvagule, R.Bruvere, M. Eglite, N.Gabruševa, G.Feldmane. Latvijas Černobilas avārijas seku likvidētāju veselības traucējumi 14-15 gadus pēc darba piesārņotajā vidē. ZRaksti/RSU, medicīnas bāzes zinātnes, pp 138-145,2002.
22.      Whittle H, Jaffar S, Wandsborough M, Mendy M, Dumpis U, Collinson A, Hall AV. Hepatitis B infection in two Gambian villages after fourteen years of vaccination.  BMJ. 2002 Sep 14; 325(7364): 569.
23.      Zampino R, Lobello S, Chiaramonte M, Venturi-Pasini C, Dumpis U, Thursz M and Karayiannis P Intra-familial transmission of hepatitis B virus in Italy: phylogenetic sequence analysis and amino-acid variation of the core gene. Journal of Hepatology 2002. J Hepatol. 2002 Feb;36(2):248-53
24.      Tracevska T., Jansone I., Broka L., Marga O., Baumanis V. Mutations in the rpoB and katG genes leading to drug resistance in Mycobacterium tuberculosis in  Latvia.  Journal of Clinical Microbiology, 2002,v.40,3789-3792
25.      Tracevska T., Baumanis V., Jansone I., Broka L., Marga O., T.Lillebaek. Prevalence of beijing genotype in Latvian multi-drug resistant Mycobacterium tuberculosis isolates. International Journal of Tuberculosis and Lung disease . Inpress.2002.
26.      Ranka R., Salmina k., Bormane A., Baumanis V. Genetic diversity of Borrelia burgdorferi in ixodes ricinus and I.persulcatus ticks collected in Latvia. European Journal of Biochemistry, 2002,v.269,s.1,p. 86.
27.      Pliss L., Baumanis V., Krumina A., Pronina et al. Typical mitochondrial mutations of the Latvian population. Journal of Biochemistry, 2002,v.269,s.1,p.37
28.      Tracevska T., Baumanis V., Jansone I., Broka L., Marga O. Evaluation of gene pathogenesis. 2002, Keystone Symposia Abstract Book, p.60
29.      Krumina A., Krumina L., Lazdins M., Svabe V., Krumina Z., Teibe U., Baumanis V. CA repeats in the first intron of the CFTR gene in cystic fibrosis patients and healthy Latvians. European Journal of Human Genetics, 2002, v.10, S.1,p. 213
30.      Line A., Stengrevics A., Slucka Z., Li G., Jankevics E., Rees R.C. Serological identification and expression analysis of gastric cancer-associated genes. Br.J.Cancer  Jun 5;86(11):1824-1830, 2002.
31.      Erenpreisa Je., Ivanov A., Endopolyploidy in development and cancer: Apossible relation to genotixic resistance of malignant tumours., Vestis LZA,  ser R. Nr.1/2, 1-6. 2002.
32.      Erenpreiss J., Hlevicka S., Zalkans J., Erenpreisa Je. Effect of leukocytospermia  on sperm DNA integrity: a negative effect in abnormal semen samples.  J.Andrology, 2002, 23: 717-723.  
33.      Klovins, J., Overbeek, G. P., van den Worm, S. H., Ackermann, H. W., and van Duin, J. (2002) Nucleotide sequence of a ssRNA phage from Acinetobacter: kinship to coliphages, J Gen Virol 83, 1523-1533.
Discuss in forum
 
Date: 20.03.2007 at 12:45:33
   2001
19.      Pumpens P., Grens E. HBV core particles as a carrier for B cell/T cell epitopes. Intervirology, 44(2-3): 98-114, 2001.  
20.      Lazdina U., Cao T., Steinbergs J., Alheim M., Pumpens P., Peterson D.L., Milich DR, Leroux-Roels G, Sallberg M. Molecular basis for the interaction of the hepatitis B virus core antigen with the surface immunoglobulin receptor on naive B cells. J. Virol, 75: 6367-6374, 2001.
21.      Pumpens P., Grens E. [Vaccines and other immunobiological tools today and tomorrow]. Latvijas Ārsts, N 10. 28-32, 2001.  
22.      Dumpis U., Edward C., Holmes E., Mendy M.  ,  Hill A., Thursz M., Hall A., Whittle H., Karayiannis P. Transmission of hepatitis B virus infection in Gambian families revealed by phylogenetic analysis. Journal of Hepatology. 35, 99-104, 2001.
23.      Dumpis U., Mendy M., Hill A.V., Thursz M., Hall A., Whittle H., Karayiannis P. Prevalence of HBV core/promoter/core mutations in Gambian chronic carriers.   Journal of Medical Virology 65; 4: 664-670, 2001.
24.      Kalnina A., Gabruševa N., Brūvere R. , Zvagule T, Heisele O., Volrāte Ā., Feldmane G., Meirovics I.. Phenotypical characteristics of leukocyte membranes in Chernobyl clean-up workers from Latvia: use of the fluerescent probe ABM. Proc. Latvian Acad. of Sciences, v.55, Nr 1, 6-14, 2001.
25.      Heisele O., Ferdats A., Engele L, Rupais A. Clinical value of melanoma associated antigens. J.Tumor Marker Oncology, 2001, v.16, Nr 2, p.106.
26.      Kurjane N., Bruvere R., Shitova O., Romanova T., Jaunalksne I., Kirschfink M., Sochnev A. Analysis of the Immune Status in Latvian Chernobyl Clean-up Workers With Non-Oncological Thyroid Diseases. Scandinavian J. Immunology, , vol 54, 528-533, 2001.
27.      Mironova-Ulmane N., Pavlenko A., Zvagule T., Karner T., Bruvere R., Volrate A. Retrospective Dosimetry for Chernobyl Workers in Latvia. – Radiation Protection Dosimetry, vol. 96, 237-240, 2001.
28.      Erenpreisa Je.,Cragg M.S. Mitotic death: A mechanism of survival? A review. Cancer Cell International 1:1 (online: www.cancerci.com), 2001.
29.      Erenpreiss Ju., Bars J., Lipatnikova J., Erenpreisa Je., Zalkalns J. Comparative study of cytochemical tests for sperm chromatin integrity. Journal of Andrology (USA), 22: 45-53, 2001.
30.      Ivanovs A.,Erenpreisa Je. [Changes of mitotic regime in the malignant tumours]. ‘Jums kolegi’, 2: 34-39 (in Latvian), 2001.  
31.      Erenpreisa Je., Ivanov A. Review: Endopolyploidy in development and cancer: A possible relation to genotoxic resistance of malignant tumours. Vestis LZA, Ser.B, 2001.
32.      Erenpreiss Ju., Hlevicka S., Zalkalns J.,  Erenpreisa Je. Impact of leukocytospermia on sperm DNA integrity: Dramatic effect in infertile men. J. Andrology (USA), 2001.
33.      Baumanis V., Kalnina V., Jansone I., Bormane A., Marga O., Pančuka T., Pole I. Molecular typing of bacterial infections in Latvia, The European Journal of Biochemistry, v.268, S1,  48, 2001.
34.      Pole I.  Jansone I., Broka L., Puzuka A., Panchuka T. , Marga O., Baumanis V. Molecular epidemiology of tuberculosis in Latvia. The International Journal of Tuberculosis and Lung disease, Vol.5, Nr.11, 140-141, 2001.
35.      Baumanis V., Kalnina V., Jansone J., Bormane A., Ranka R. Marga O., Pole I., Panchuka T. Molecular typing of bacterial infections in Latvia. European Journal of Biochemistry, v.268, s.1, 48, 2001,  
36.      Baumanis V., Kloviņš J., Ranka R., Vetcmane-Vetce K., Puzuka A., Lavrinoviča M., Bormane A., Kalniņa V. Incidence of Borrelia Burgdorferi infected ticks in Latvia and their molecular typing. Proceedings of the Latvian Academy of Sciences, v.55, 164-170, 2001.
37.      Panchuka T., Baumanis V., Jansone I., Broka L., Marga O. Evaluation of gene mutations leading to drug resistance of Mycobacterium tuberculosis in Latvia.Submitted to Journal of Clinical Microbiology, 2001.  
38.      Krūmiņa A., Kroškina V., Keišs J.,  Mališeva B., Baumanis V. Ar hereditāro hemohromatozi saistītā gēna HFE mutācijas Latvijas poplulācijā.LMA Zinātniskie raksti, Rīga, AML/RSU, 134-138, 2001
39.      Pumpens P., Baumanis V. [Gene therapy, what it is] .Latvijas Ārsts, Nr.1, 37-40, 2001,  
40.      Baumanis V., Pumpens P. [Gene therapy, real success] .Latvijas ārsts, Nr.3, 40-43, 2001.
41.      
42.      Liepinsh E., Baryshev M., Sharipo A., Ingelman-Sundberg M, Otting G and Mkrtchian S. Thioredoxin fold as homodimerization module in the putative chaperone ERp29: NMRstructures of the domains and experimental model of the 51 kDa dimer. Structure (Camb).;9(6):457-471,2001 Jun.
43.      Sharipo A., Imreh M., Leonchiks A., Branden C., Masucci M.G. cis-Inhibition    of proteasomal degradation by viral repeats: impact of length and amino acid composition. FEBS Lett. 15;499 (1-2):137-142, 2001Jun.
44.      Tihomirova L., Sinicka O., Smite D., Stengrevics A., Recurrent mutations of BRCAI gene as diagnostic genetic markers of hereditary breast cancer in Latvian Pacients. J. of tumor marker Oncology, vol 16. Nr.2, 2001.
45.      T. Zvagule, N. Mironova-Ulmane, A. Pavlenko, T. Karner, R.Bruvere, N.Gabruševa, A. Volrate. Retrospective dosimetry and clinical follow-up program for Chernobyl clean-up workers in Latvia. Proceedings of the IRPA regional congress on radiation protection in Central Europe Dubrovnik, Croatia, May 20-25, 2001 (ISBN 953-96133-3-7)  
46.      A.Leice, R. Bruvere, N. Gabruševa, V. Balodis. Evaluation of Chernobyl Accident Late Health Effects by Hematological and Clinical Biochemistry tests. Acta Universitatis Latviensis. Medicine.2001, vol 643, 77-84.  
Discuss in forum
 
Date: 20.03.2007 at 12:43:23
   2000
1.      Sobotta D., Sominskaya I., Heermann K.H., Kaluza G., Meisel H., Jansons J., Pumpens P.,  Schmitt S., Gerlich W.H. Mapping of immunodominant B-cell epitopes and the human serum albumin binding site in natural hepatitis B virus surface antigen of defined genosubtype. Journal of General Virology, Vol..81.   Nr. 2., 369-378, 2000.  
2.      Preikschat P, Kazaks A, Dishlers A, Pumpens P, Kruger DH, Meisel H Interaction of wild-type and naturally occurring deleted variants of hepatitis B virus core polypeptides leads to formation of mosaic particles. FEBS Lett. 478, 127-132, 2000.
3.      Cielens I, Ose V, Petrovskis I, Strelnikova A, Renhofa R, Kozlovska T, Pumpens P. Mutilation of RNA phage Qβ virus-like particles: from icosahedrons to rods. FEBS Lett.  482(3): 261-264, 2000.  
4.      Viksna L., Sominska I., Kozlovska T., Jansons J., Pumpens P., Arsa F., Rozentale B., Sondore V.  [Specific diagnostics of viral hepatitis B. Current problems].  LMA Vestis,  lpp.210-213, 2000.
5.      Tars K., Fridborg K., Bundule M., Liljas L. Structure determination of bacteriophage PP7 from Pseudomonas aeruginosa: from poor data to a good map. Acta Crystallogr D Biol Crystallogr;56 ( Pt 4):398-405,2000.
6.      Tars K., Fridborg K., Bundule M., Liljas L. The three-dimensional structure of bacteriophage PP7 from Pseudomonas aeruginosa at 3.7-A resolution. Virology 272(2):331-337, 2000.  
7.      Erenpreisa Je., Ivanov A., Dekena G., Vitina., Krampe R., Freivalds T., Seli vanova G., Roach. H.I. Arrest in metaphase and anatomy of mitotic  catastrophe: mild heat shock in two human osteosarcomma cell lines. Cell Biology Intern. 24, 61-70, 2000.
8.      Licis, N., Balklava, Z. and van Duin, J. Forced retroevolution of an RNA bacteriophage. Virology, 271, 298-306, 2000.
9.      Illidge T., Cragg M., Fringes B.,Olive P., Erenpressa Je. Polyploid giant cell provide a survival mechanism for p-53 mutant cells after DNA damage. Cell Biology Intern., 24, 621-633, 2000.
10.      Erenpreisa Je., Cragg M., Fringes B., Sharakhov I., Illidge T. Release of mitodic descendants by giants cells from irradiated Burkitt lymphoma cell lines. Cell Biology Intern., 24,  635-648, 2000.
11.      Erenpreisa Je., Dalmane A., Erenpreiss Ju. Janis Olgerts Erenpreiss and his theory of carcinogenesis. Acta Medico-Historica Rigaensis, Riga, vol.5, 281-285, 2000.
12.      Erenpreisa Je. “Tamed” chaos in embryonal deveopment and carcinogenesis: a holistic view. Proc. Latvian Acad. Sci., 54,  nr.1-2, 1-8, 2000.
13.      Pancuka T., Baumanis V., Jansone I., Marga O., Broka L. Diagnostics of rifampicin resistant forms of tuberculosis in Latvia by amplification methods. Genodiagnostics in modern medicine., Venera-press, Moscow (in Russian), 286-287,2000.
14.      Krumina A., Kroškina V., Švabe V., Krumina Z., Lazdinš M., Baumanis V.Cystic               fibrosis causing mutatios in Latvia. Zin. Raksti  AML/RSU, 102-105,  2000.
15.      Krumina A., Kroškina V., Keiss J., Baumanis V. Hereditary haemochromatosis mutations in Latvia. European Journal of Human Genetics, vol 8, rec.18-119, 2000.
16.      Krumina A., Kroškina V., Mališeva B., Baumanis V. Hereditary harmochromatosy cassing gene HFE mutations in Latvia. Zinātniskie Raksti AML/RSU, 103, 2000.
17.      Lielpetere I., Bruvere R., Heisele O., Volrate A., Feldmane G. The parameter of immune system of fire-fighters and security persons. Tev. Kolēģi, decembris, Nr.10, 2000.  
18.      Bruvere R. Pilmane M., Feldmane G., Volrate A., Pjanova D. Intracellular double-standed RNA structures stimulated by diffent stress factors. Proc. Latvian Acad. Sci., Section B., vol 54, nr.1-2, 18-24, 2000.  
19.      Mazarevica G., Freivalds T., Bruvere R. Gabruševa N., Leice A., Zvagule T. Changes in optimal properties of erythrocytes at different pH in Chernobyl clean-up workers. Scientific Problems of disaster Medicine and Emergency Medical Acid. Proceedings Acad. Sci. Ukraine, Kiev, Ukraine, 509-516, 2000.
20.      Kalnina I., Bruvere R., Zvagule T., Gabruševa N., Heisele O., Volrate A., Feldmane G., Meirovics I. Physicall-chemical characteristics of leukocyte membranes in chernobyl clean-up workers from Latvia. Problems of Disaster Medicine and Emergency Medical Acid. Proceedings Acad. Sci. Ukraine, Kiev, Ukraine, 517-522, 2000.
21.      Mazarevica G. Freivalds T., Brūvere R., Gabruševa N., Leice A., Zvagule T. Reactive properties of separate erythrocytes of Chernobyl cean-up workers at different pH-SPIE Proceedings. Optical Diagnostic of Living Cells III, SanJose, USA, vol.3921, 163-171, 2000.
22.      Heisele O., Ferdats A., Engele L. Melanoma Associated Antigens as Additional Markers of Tumor Progression. J. Tumor Marker Oncology, vol.15, nr. 2, 147-153. 2000.
23.      Cssokay B., Tihomirova L., Stengrevics A., Sinicka O., Kamerade ., Frequency of 538 ins BRCA 1mutation carrier cancer pateints from Latvia. Tumor Marker Oncology, 15, nr.1, 19-20, 2000.
24.      Pjanova D. [Intracellular ds-RNA-activators or inhibitors of proteinkinaze R (PKR) Zinatniskie Raksti /AML/RSU, 105-110, 2000.
25.      Serfling E., Berberich-Siebelt F., Chuvpilo S., Jankevics E.,Klein-Hessling S., Twardzik T., Avots A.The role of NF-AT transcription factors in T cell activation and differentiation. Biochim Biophys Acta, 1498(1),1-18, 2000.
26.      Vanags I., Sondore A., Daugulis E., Kokars I., Ose V., Ginekoloģiskās laparoskopijas anestezioloģiskā nodrošinājuma aktualitātes. Zinātniskie  Raksti /AML/RSU, 27-30, 2000.
27.      Erenpreisa Je., Cragg M., Ivanov A., Illidge T. Nuclear envelope limited    chromatin sheets in p53 mutated Burkitt lymphoma cell lines after DNA and sprindle damage. W. Mejbaum-Katzellenbogen Mol.Biol. Seminar, Wrozlav Cell&Mol. Biol. Letts 5, nr.2, 238, 2000.
28.      Erenpreisa Je., Cragg M., Alston R., Page A., Illidge T. Apoptotic polykaryons, chromatin diminution and survival mechanism in polyploid cells derived from p53  mutated lymphoma cell lines after genotoxic damage. Cell&Biol.Letts 5, nr.2, 236-237, 2000.
29.      Siray H., Fromel C.,  Voronkova T., Hahn S., Arnold W., Schneider-Mergener J., Schherneck S., Ulrich R. An Immunodominant, Cross-Reactive B-cell Epitope region IS Located at the C-Terminal Part of the Hamster polyomavirus Major Capsid Protein VP1. Viral Immunology 13, 533-545, 2000.
30.      Sylvin H., Matvienko O., Leonchiks A., Alving K., Van der Ploeg I.  Molecular cloning, expression, and purification of pig interleukin-5. Immunogenetics.51(1):59-64, 2000.
31.      Forsell K., Xing L., Kozlovska T., Cheng R.H., Garoff H. Membrane proteins organize a symmetrical virus. EMBO J. Oct 2;19(19):5081-91,2000.
Discuss in forum
 
Date: 20.03.2007 at 12:41:25
   1999

1.      Pumpens P., Grens E., Hepatitis B core paricles as a universal display model: a structure-function basis for development. FEBS Latters 442, 1-6, 442,1999.
2.      Preikschat P., Borisova G., Borschukova O., Dislers A., Mezule G., Grens E., Krüger D.H., Pumpens P.,  Meisel H. Expression, assembly competence and antigenic properties of hepatitis B virus core gene deletion variants from infected liver cells. J Gen Virol. 80, 1777-1788 ,1999.  
3.      Lachmann, S., Meisel H., Muselmann C., Koletzki D., Gelderblom H.R., Borisova G., Krüger D.H., Pumpens P., Ulrich R. Characterization of potential insertion sites in the core antigen of hepatitis B virus by the use of a short-sized model epitope. Intervirology, 42, 51-56, 1999.  
4.      Borisova G., Borschukova O., Skrastina D., Dislers A., Ose V., Pumpens P. Grens E. Behavior of a short preS1 epitope on the surface of hepatitis B core particles. Biol. Chem., 380, 315-324, 1999
5.      Klovins J., Van Duin J., A long-range pseudoknot in Qb is essential for replication. J.Mol.Biol., 294, 875-884, 1999.
6.      Ulrich R., Koletzki D., Lachmann S., Lundkvist A., Zankl A., Kazaks A., Kurth A., Gelderblom H.R., Borisova G., Meisel H., Kruger D.H., New chimeric hepatitis B virus core particles carrying hantavirus (serotype Puumala) epitopes: immmunogenicity and protection against virus challange, J.of  Biotechnology 73, 141.-153., 1999.
7.      Baumanis V., Jansone I., Marga O., Broka I., Pancuka t., Mandrika I., Evaluation of two amplification technologies for the detection of Mycobacterium tuberculosis. Biochemie, Vol. 81, Nr.6, 396, 1999.
8.      Chuvpilo S., Zimmer M., Kerstan A., Glockner J., Avots A., Escher C., Fischer C., Inashkina I., Jankevics E., Berberich-siebelt F., Schmitt E. Serfling E., Alternative polyadenylation events contribute to the induction of NF-Atc in effector T cells. Immunity, Vol.10, 261-269, 1999.
9.      Bruvere R., Pilmane M., Feldmane G., Volrate A., Loza V., Kinetics of cell-derived double-standed ribonucleic acids during differentiation. Analytical Cellular Pathology, Vol. 18, Nr.1, 16, 1999.
10.      Mazarevica G., Leice A., Auce Z., Freivalds T., Bruvere R., Morpho-functional analysis of erythroid system of the Chernobyl clean-up workers from Latvia. Analytical cellular Pathology, Vol. 18, Nr.1., 39, 1999.
11.      Bruvere R., Leice A., Bruveris U., Evaluatin of Chernobyl acciedent health effects by hemathological and Clinical biochemistry tests. Epidemilogy, vol. 10, Nr. 4, 518,1999.
12.      Heisele O., Engele L., Ferdats A., Bruvere R., Desjatnikova I., Melanoma associated antigens as additional markers of tumor growth. J. Tumor Oncology, Vol. 14, Nr.2, 62063, 1999.
13.      Kristufek V., Fischer J., Buhrmann J., Zeltins A., Schrempf H., In situ monitoring of chitin degradation by Streptomyces lividans  pCHIO12 within Enchytraeus crypticus (Oligochaeta) feeding on Aspergillus proliferans. FEMS Microbiol. Ecology, Vol. 28, 41-48, 1999.  
14.      Muiznieks I., Rostoks N., Schmitt R. Effective regulation of transcription of the bacterial raf operon by two Raf repressor dimers and CAP protein that bend DNA in opposite directions. Biol. Chem., 380, 19 –29, 1999.
15.      Chuvpilo S., Kerstan A., Glokner J., Avots A., Escher C., Fischer C., Innashkina I., Jankevics E., Siebelt F., Serfling E. Coordinated synthesis and nuclear translocation of NF-ATc isoforms during T cell  activation (abstract0. Immunobiology, Vol. 197, 184-185, 1999.    
16.      Chuvpilo S., Kerstan A., Glokner J., Avots A., Escher C., Fischer C., Innashkina I., Jankevics E., Serfling E., Berberich-Siebelt F., Hlubek F.,Brabletz T. Multiple NFATc isoforms  with individual transcripptional properties are synthesized in T Lymphocytes. Immunology 162 (12), 7294-7301, 1999.  
17.      Tihomirova L., Csokay B., Stengrevics A., Sinicka O., Kamerade R.,  Hereditary  Brest cancer in Latvia: Mutation Analysis of the BRCA 1 gene. Disease Markers.15, 97,1999.
18.      Zhilevica A., Bondare D., Strozha I., Cimanis A., Feldmane G., Grante H., Treimane R., Linē A.. Interferon alpha therapy in chronic myeloid leukemia and detection of bcr/abl transcripts. Proc.Latvian Acad.Sci., Section B, vol.52, No.3/4, 102-107,1999.
19.      Petuhov V.I., Strozda I., Zhilevich A.Bondare D., Line A., Jankevics E., Tsimanis A., Treimane R., Krumina A. Effectiveness of alfa-interferon therapy and bcr-abl transcripts in patients with chronic myeloid leukemia (CML). Gematol. Transfuziol., 44(1):3-6, 1999, [in Russian],  
20.      Petuhov V.I., Bondare D., Stroza I., Jankevics E., Line A., Zhilevica a., Kovaleva Z., Teilane I. Three family cases of CML expressing hybrid BCR-ABL gene. Gematol.Transfuziol., 44(3):46-47,1999, [in Russian],
21.      Zhilevich A., Bondare D., Stroza I., Petuhov V., Jankevics E., Line A. Correlation of BCR-ABL  expression with prognosis of CML. Latvijas Ārsts,(1):18-22,1999, [in Latvian].
22.      Dumpis U., Crook D., Oksi J. Tick-borne encephalitis. Clinical Inefectious diseases 141-147,1999.  
Discuss in forum
 
Date: 20.03.2007 at 12:39:50
   1998
1.      Avota E., Vishnevsky J., Luce J., Berzins V.,Biebricher C.K. The natural 6 S RNA found in Qbeta- infected cells is derived from host and phage RNA. J. Mol. Biol., 276, 7-17,1998.
2.      Berzins V. (Editor). Basic Cloning Procedures.  Lab.Manual. Springer Verlag, Heidelberg, 1998.
3.      Schuh K., Kneitz B.,Heyer J., Bommhatdt U, Jankevics E., Berberich-Siebelt F, Pleffer K., Muller- Hermelink H.K., Schimpl A., Serfling E. Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice. Eur J. Immunol 28 (8): 2456-2466, 1998.
4.      Krumina A., Kroshkina V., Lazdins M., Baumanis V., Analysis of Rsal polymorphism in the gene HLA-H of haemochromatosis in the Latvian population. European Journal of Human Genetics, Vol.6, suppl.1, 104,1998.
5.      Krumina  A., Kroschkina V., Svale V., Krumina Z., Lazdins M., Baumanis V. Cystic Fibrosis and CFTR gene mutations in Latvia. European Comission Concered Action on Cystic Fibrosis Newsletter, vol.3, Nr. 8, 14-15,1998.
6.      Vasiljeva I., Kozlovska T., Cielens I., Strelnikova A., Kazaks A., Ose V., Pumpens P. Mosaic Q coats as a new presentation model. FEBS Letters, 431, 7-11 1998.  
7.      Fehr T., Skrastina D., Pumpens P., Zinkernagel R.M. T cell-independent type I antibody response against B cell epitopes expressed repetitively on recombinant virus particles. Proc.Nat.Acad.Sci. USA, 95, 9477-9481, 1998.  
8.      Baumanis V. Jansone I., Mandrika I., Zaļeckis R., Marga L., Broka L. [Molecular diagnostics of tuberculosis in Latvia.]Polymerase chain reaction in the control and diagnostics of infections diseases. Publishin house  "Posledņeje slovo",Moscow, 102-103, 1998.
9.      Baumanis V. Jansone I. Mandrika I., Marga O., Leimanis J., Broka L[Molecular biology and diagnostics, presentisa and therapy of tuberculosis in Latvia.] Latvijas ārsts, Nr.8, 412-419,1998.
10.      Leimanis J., Baumanis V., Marga O.,Jansone I., Mandrika I., Broka L., Mandrika I. Molecular diagnosis of tuberkulosis in Latvia. The International Journal of Tuberculosis and Lung disease, v.2, 389-390, 1998.  
11.      Heisele O., Ferdats A., Bruvere R., Feldmane G., Petrovska R., Altered expression pf melanoma associated antigens by the immunomodulators RIGVIR and Lariphan. Journal of Tumor Marker Oncology, Vol.18, Nr.2, 55, 1998.
12.      Heisele O., Engele L., Ferdats A., Bruvere R., Rupais A., Desjatnikova I., Expression of Mage genes as signal of melanoma progression. Tumor Biology. vol 19, suppl.2.108, 1998.
13.      Bruvere R., Feldmane G., Heisele O., Volrate A., Balodis V., Several immune system functions of the residents from territories exposed to pulse radio-frequency radiation. Epidemiology, Vol.9, Nr.4, 109,Suplement, 1998 .
14.      Axblom C., Tars K., Fridborg K., Orna L., Bundule M., Liljas L. Structure of Phage fr Capsids with a deletion in the FG loop: Implications for Virus Assembly. Virology, 249, 80-88, 1998.
15.      Ulrich R., Lundkvist A., Meisel H., Koletzki D., Sjolander K.B, Gelderblom H.R, Borisova G., Schnitzler P., Darai G., Kruger D.H.Chimaeric HBV core particles carrying a defined segment of Puumala hantavirus nucleocapsid protein evoke protective immunity in an animal model. Vaccine 16 (2-3):272-280, 1998.
16.      Hassen Siray , Ozel M., Jandrig B., Voronkova T., Jia W., Zocher R.,  Arnold W., Scherneck S, Kruger D.H., Ulrich R. Capsid Protein-Encoding Genes of Hamster Polyomavirus and Properties of the Viral Capsid. Virus Genes 18:1, 39-47,1998.    
17.      Muiznieks I., Doerfler W. Unusual electrophoretic properties of DNA fragments having specific sequences in the single stranded overhangs. Nucl. Acids.Res., 26, 1899 – 1905, 1998.
18.      Muiznieks I., Rostoks N. Analysis of Specific Protein-DNA Interactions. In:  Basic Cloning Procedures. V.Berzins (ed.), Springer, pp. 68 –104, 1998.
19.      Klovins J., Berzins V., Van Duin J. A long-range interaction in Qb RNA that bridges the thousand nucleotides between the M-site and the 3` end is required or replication. RNA 4, 948-957, 1998.  
20.      Leonchiks A., Liepinsh E., Barishev M., Sharipo A., Masucci M.G., Otting G. Random coil conformation of a Gly/Ala-rich insert in IkappaB alpha excludes structural stabilization as the mechanism for protection against proteasomal degradation. FEBS Lett. 4;440(3):365-369,1998 .
21.      Licis, N., van Duin, J., Balklava, Z. and Berzins, V. (1998) Long-range translational coupling in single stranded RNA bacteriophages: an evolutionary analysis. Nucl. Acids Res., 26, 3242-3246.
22.      Mkrtchian S., Baryshev M., Matvijenko O., Sharipo A, Sandalova T, Schneider G, Ingelman-Sundberg M, Mkrtchian S. Oligomerization properties of ERp29, an endoplasmic reticulum stress protein. FEBS Lett. 24; 431(3): 322-326, 1998.
23.      Sharipo A., Imreh M., Leonchiks A., Imreh S., Masucci M.G. A minimal glycine-alanine repeat prevents the interaction of ubiquitinated IkappaB alpha with the proteasome: a new mechanism for selective inhibition of proteolysis. Nature Med. 4(8): 939-944, 1998.
24.      Zhilevica a., Bondare D., Strozda I., Cimanis A., Feldmane G., Grante H., treimane R., Line A. Interferon alpha therapy in chronic myeloid leukemia and detection of bcr/abl transcipts. Proc.Latvian Acad.Sci. Section B, vol.52, No.3/4, 102-107, 1998.
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Date: 20.03.2007 at 12:38:00
   1997
1.      Mandrika I., Baumanis V., Jansone I., Skangals A., Berzins V.  Development of  immunoenzymatic reactions of peptides using recombinant hybrid proteins.  Biochemistry-Moscow,  62,(2), 217-220, 1997.
2.      Borschukova O., Skrastina D., Dislers A., Petrovskis I., Ose V., Zamurujeva I., Borisova G. Modified hepatitis B core particles as possible vaccine carriers. Vaccines-97, 33-37, 1997.
3.      Avots A.,Hoffeyer A., Flory E., Cimanis A., Rapp U.R., Serfling E. GABP factors bind to a distal IL-2 enchancer and contibute to c-Raf mediated increse in IL-2 induction. Mol. Cel Biol. ,vol.17,N 8, 4381-4389, 1997.
4.      Kilchewska K., Jackevicha L., Steinbergs J., Gusars I., Sallberg M., Tsimanis A.  Monoclonal anti FosB antibody specific for pre-determined, non-structural region of the fosB protein. Hybridoma, ,vol.16.,N 3, 277-280, 1997.
5.      Klovins J., Tsareva N.A., de Smit M.H., Berzins V. and van Duin J.  Rapid evolution of translational control mechanisms in RNA genomes.  J.Mol.Biol.,vol.265, 372-384 , 1997.
6.      Steinbergs J., Kilchewska K., Lazdina U., Dishlers A, Ose V, Sallberg M.,  Tsimanis  A.  Short synthetic CDR-peptides forming the antibody combining site of the monoclonal antibody against RNA bacteriophage fr neutralize the phage activity.  Hum.Antib.Hybridomas,vol. 7,106-112, 1997.
7.      Grene E., Mezule G., Borisova G., Pumpens P., Bentwich Z., Arnon R. Relationship between antigenicity and  immunogenicity of chimeric core particles carrying HIV-1 epitopes. AIDS Res.  and Human Retroviruses, 13, 41-51, 1997.
8.      Kozlovska T.M., Cielens I., Vasiljeva I., Bundule M., Strelnikova A., Kazaks A.,  Dislers A., Dreilina D.,  Ose V., Gusars I., Pumpens P. Display vectors. II. Recombinant capsid of RNA bacteriophage Qbeta as a display moiety. Proc. Latv.Acad.Sci., 51 (N 1-2), 8-12, 1997.
9.      Koletzki D., Zankl A., Gelderblom H. R., Meisel H., Dislers A., Borisova G., Pumpens P., Krüger D.H., Ulrich R.  A new strategy for construction of chimeric „readthrough“ HBcAg particles in vaccine  development. J.Gen.Virol., 78, 2049-2053,  1997.
10.      Ulrich R., Koletzki D., Zankl A., Schulz A., Meisel H., Krüger D.H., Gelderblom H.R., Dislers A.,  Borisova G., Pumpens P.  A new strategy to generate HBcAg particles  presenting foreign epitopes. Vaccines-97, Ed. by F.Brown, D.Burton, P.Doherty, J.Mekalanos, E.Norrby. Cold Spring  Harbor Laboratory, 235-240 , 1997.
11.      Nekrasova O.V., Boichenko V.E. Boldyreva E.F., Borisova G.P., Pumpen P., Perevozchikova N.A.,  Korobko V.G. Bacterial synthesis of immunogenic epitopes of foot-and-mouth disease virus fused either to  human necrosis factor or to hepatitis B core antigen. Bioorg. Chem.  (RUSSIA),  23 (2), 118-126, 1997.
12.      Baumanis V., Jansone I., Skangals A., Mandrika I. and Berzins V.  Synthesis of recombinant atrial natriuretic peptide (rANP) using hybrid fusion protein-phage fr coat/ ANP (CP/ANP). Peptides, 18,(8), 1229-1235, 1997.
13.      Jorg Heyer, Burkhard Kneitz, Kai Schuh, Eriks Jankevics, Friederike Siebelt, Anneliese Schimpl,Edgar Serfling. Inefficient  Termination of Antigen Responses in NF-ATp-Deficient Mice. Immunobiol., vol.198, 162-169, 1997.
14.      Schuh K, Kneitz B, Heyer J, Siebelt F., Fischer C, Jankevics E, Rude e., Schmitt E., Schimpl A., Serfling E. NF-ATp plays prominent role in the transcriptional induction of Th2-type lymphokines. Immunol Lett  57 (1-3):171-5, 1997.
15.      Bruvere R., Heisele O., Feldmane G., Volrate A., Gabruseva N., Balodis V. Effect of pulse radio-frequence radiation on the functioning of the immune system. Proceedings of the Latvian Academy of Sciences , Nr. 5/6, 270-276, 1997.
16.      Zeltins A., Schrempf H., Specific Interaction of the Streptomyces chitin-binding protein CHB1 with - chitin: The role of individual tryptophain residues. Eur. J. Biochem., Vol. 246, 557-564, 1997.  
17.      Klovins J., Van Duin J., Olhstorn R., Rescue of the RNA phase genome from Rnase III cleavage. Nucl.Acids Res., 25, 4201-4208, 1997.
18.      Levitskaya J., Sharipo A., Leonchiks A., Ciechanover A., Masucci M.G. Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc Natl Acad Sci U S A. Nov 11; 94(23):12616-12621, 1997.
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Date: 20.03.2007 at 12:24:52
   1996
1.      Golmohammadi R., Fridborg K., Bundule M., Valegard K., Liljas L. The crystal  structure of  bacteriophage Qbeta at 3.3 A resolution. J.Mol.Biol.,  4, 543-554, 1996.  
2.      Kozlovska T.M., Cielens I., Vasiljeva I., Strelnikova A., Kazaks A., Dislers A.,  Dreilina D., Ose V., Gusars I., Pumpens P.  RNA phage Qbeta coat protein as a carrier  for foreign epitopes. Intervirology,  39, 9-15, 1996.  
3.      Loza V., Feldmane G.   Biomodulatory functions of the double - stranded ribonucleic acids.  Acta Medica Baltica,  V.3, Nr.1, 12-17, 1996.
4.      Loza V., Pilmane M., Bruvere R., Feldmane G., Ose V., Volrate A., Sundler F..  Double-stranded ribonucleic acids in cells during induced differentiation.  Acta Medica Baltica, 1, 22-30, 1996.
5.      Sauka E., Banders U., Svirska R., Kolupajeva T.  A simple immuno dot-blot assay for detection of antibodies to human immunodeficiency virus  type I and type II.  Acta Medica Baltica,  V.3, 1, 58-62, 1996.
6.      Steinbergs J., Kilchewska K., Jackevich L., Bichko V., Tsimanis A.  The structure of the variable region of monoclonal antibody 13D3 that recognizes a linear epitope spanning the C-terminus of hepatitis B e antigen.  Proc. Latvian Acad. Sci.,  V.50, Nr.2 (583), 9-12, 1996.
7.      Nikolajeva V., Eze D., Kamradze A., Indulena M., Muiznieks I.  Protective effect of adenylate deaminase (from Penicillium lanoso-viride) against acute infections in mice. Immunopharmacology. 35, 163 - 169, 1996.
8.      Schrempf  H., Blaak H.,Zeltins A., Fischer S., Schnellmann.J., The chitinolytic system of streptomycetes. Chitin enzymology, Vol. 2, 195-202, 1996.
9.      Borisova G., Borschukova O., Skrastina D., Mezule G., Dislers A., Petrovskis I., Ose V., Gusars I., Pumpens P., Grens E.  Display vectors. I. Hepatitis B core particle  as a display moiety. Proc. Latv.Acad.Sci., section B, vol. 51.,N1/2 (588-589), 1996.
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Date: 20.03.2007 at 12:09:42