Pētījumi

Strukturālā bioloģija, biotehnoloģija un virusoloģija

A. Leončika grupa

Pētniecība

Otru mērķgrupu veido savienojumi ar potenciālu pretvēža aktivitāti kā iespējami zāļu kandidāti angioģenēzes un audzēju metastāžu inhibēšanai (MMP inhibitori), un kā diagnostiski testa marķieri malignu B-šūnu noteikšanai asinīs (RNS aptamēri).

Zinātniskais personāls

Sadarbības partneri

Publikācijas

• Starptautiskas

• Pyrrolomycins as antimicrobial agents. Microwave-assisted organic synthesis and insights into their antimicrobial mechanism of action Raimondi, M.V., Listro, R., Cusimano, M.G., La Franca, M., Faddetta, T., Gallo, G., Schillaci, D., Collina, S.,, A Leončiks, Barone, G. , Bioorganic and Medicinal Chemistry, 27 (5), pp. 721-728. PMID: 30711310 , 2019
• Expression of the chemokine receptors CCR1 and CCR2B is up-regulated in peripheral blood B cells upon EBV infection and in established lymphoblastoid cell lines Kholodnyuk, I., Ž Rudevica, A Leončiks, Ehlin-Henriksson, B., Kashuba, E , Virology, 512, pp. 1-7 , 2017
• Discovery of a New Class of Sortase A Transpeptidase Inhibitors to Tackle Gram-Positive Pathogens: 2-(2-Phenylhydrazinylidene)alkanoic Acids and Related Derivatives Maggio B, Raffa D, Raimondi MV, Cascioferro S, Plescia F, Schillaci D, Cusimano MG, A Leončiks, D Žuļenkovs, Basile L, Daidone G. , Molecules. 2016 Feb 19;21(2):241 , 2016
• A new class of phenylhydrazinylidene derivatives as inhibitors of Staphylococcus aureus biofilm formation Cascioferro S, Maggio B, Raffa D, Raimondi MV, Cusimano MG, Schillaci D, Manachini B, A Leončiks, Daidone G. , Medicinal Chemistry Research. (2016) May 1;25(5):870-878 , 2016
• Comparative protein profiling of B16 mouse melanoma cells susceptible and non-susceptible to alphavirus infection: Effect of the tumor microenvironment J Vasiļevska, De Souza, G.A., Stensland, M., D Skrastiņa, D Žuļenkovs, Paplausks, R., B Ķūrēna, T Kozlovska, A Zajakina , Cancer Biology and Therapy, 17 (10), pp. 1035-1050 , 2016
• Synthesis and Antibacterial Activity of 5-Phthalate and 5-Glutarate Derivatives of Milbemycins Lugiņina, J., Bizděna, E., A Leončiks, Kumpiņš, V., Grinšteine, I., Turks, M. , Chemistry of Heterocyclic Compounds, 50 (10), pp. 1404-1412 , 2015
• Synthesis, structure and biological activity of new 6,6-dimethyl-2-oxo-4-{2-[5-organylsilyl(germyl)]furan(thiophen)-2-yl}vinyl-5,6-dihydro-2H-pyran-3-carbonitriles Ignatovich, L., Spura, J., Muravenko, V., Belyakov, S., Popelis, J., Shestakova, I., Domrachova, I., Gulbe, A., Ž Rudevica, A Leončiks , Applied Organometallic Chemistry, 29 (11), pp. 756-763 , 2015
• Selenopheno[3,2-c]- and [2,3-c]coumarins: Synthesis, cytotoxicity, angiogenesis inhibition, and antioxidant properties Arsenyan, P., Vasiljeva, J., Shestakova, I., Domracheva, I., Jaschenko, E., Romanchikova, N., A Leončiks, Ž Rudevica, Belyakov, S. , Comptes Rendus Chimie, 18 (4), art. no. 3984, pp. 399-409 , 2015
• Enzymatic activity of circular sortase A under denaturing conditions: An advanced tool for protein ligation. D Žuļenkovs, Jaudzems K, A Zajakina, A Leončiks , Biochemical Engineering Journal. 82(15):200–209 , 2014
• Structural characterization of CspZ, a complement regulator factor H and FHL-1 binding protein from Borrelia burgdorferi. K Brangulis, I Petrovskis, A Kazāks, J Bogans, Otikovs M, Jaudzems K, R Ranka, K Tārs , FEBS J., 281(11):2613-22 , 2014
• High efficiency of alphaviral gene transfer in combination with 5-fluorouracil in a mouse mammary tumor model. A Zajakina, J Vasiļevska, D Žuļenkovs, D Skrastiņa, Spaks A, Plotniece A, T Kozlovska , BMC Cancer. 14:460 , 2014
• Mosaic RNA phage VLPs carrying domain III of the West Nile virus E protein. I Cielēns, L Jackeviča, A Strods, A Kazāks, V Ose-Klinklāva, J Bogans, P Pumpēns, R Renhofa , FEBS J. 281(11):2613-22 , 2014
• Discovery and structure-activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase. D Žuļenkovs, Ž Rudevica, Jaudzems K, Turks M, A Leončiks , Bioorg Med Chem. 22(21):5988-6003 , 2014
• Synthesis of quinazolinone-1,3,4-oxadiazole conjugates and studies of their antibacterial and antioxidant activity. Zicane D, Tetere Z, Mierina I, Turks M, Ravina R, A Leončiks , Journal of Chemical and Pharmaceutical Research. 6(4):1153-1158 , 2014
• NMR mapping of RANTES surfaces interacting with CCR5 using linked extracellular domains. Schnur E, Kessler N, Zherdev Y, Noah E, Scherf T, Ding FX, Rabinovich S, Arshava B, V Kurbatska, A Leončiks, Tsimanis A, Rosen O, Naider F, Anglister J , FEBS J. May;280(9):2068-84. , 2013

• Patenti

• N-(3-Hydroxy-5,7-Dimethyladamantan-1-YL)-2-(3-Oxobenzo[d]isothiazol-2(3H)-YL)Acetamide as a Novel Inhibitor for Staphylococcus Aureus Sortase A D Žuļenkovs, Ž Rudevica, A Leončiks, Jaundzems K, Zicāne D, Turks M , Europena Patent Office, Application number 13193793.0 , 2013
• N'-(2-(3-Oxobenzo[d]Isothiazol-2(3H)-YL)ACETYL) Adamantane-1-Carbohydrazide as a Novel Inhibitor for Staphylococcus Aureus Sortase A D Žuļenkovs, Ž Rudevica, A Leončiks, Jaundzems K, Zicāne D, Turks M , Europena Patent Office, Application number 13193784.9. , 2013
• Novel recombinant human cyclized erythropoietin Stonans I, Borovikova D, A Leončiks, D Žuļenkovs , European Patent Office, 10187857.7-2405 , 2011
• Human rekombinant soluble CXCR4 chemokine receptor A Leončiks, V Kurbatska, Ž Rudevica , Application number 61/341242 United States Patent and Trademark Office , 2010
• Human recombinant soluble CCR5 chemokine receptor. Tsimanis AY, Saripo A, A Leončiks, V Kurbatska, Ž Rudevica , US Patent and and Trademark Office. Application No 61/065151 , 2008

• Konferenču tēzes

• Screening of staphylococcus aureus sortase a inhibitors: novel antibiotic drug design D Žuļenkovs, A Zajakina, K. Jaundzems, A Leončiks , Химия структура и функция биомолекул, Minska, Baltkrievija , 2014
• Jauna vīrusveidīgo daļiņu virsmas enzimātiskā modifikācijas sistēma D Žuļenkovs, I Petrovskis, P Pumpēns, A Leončiks , Apvienotais Pasaules latviešu zinātnieku 3. kongress un Letonikas 4. kongress 24.-27./oktobris/2011 Medicīnas zinātne un Latvijas sabiedrības veselība XXI gadsimtā Medicīnas sekcija / p.91. , 2011

Ātrās saites

• BMC e-pasts
• Iepirkumi
• Iepirkumu arhīvs
• Masu medijiem
• EURAXESS

Grupas ātrās saites

• Pētniecība
• Zinātniskais personāls
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