Par mums

Baiba Lāce , Dr. med.

Vadošā pētniece
Telefons: +371 67808200
E-pasts: baiba.lace@gmail.com

Projekti

• Mitohondriālo slimību funkcionālā modeļa izveide un biomarķieru atlase
• Sagatavošanās vizīte projektam „Mitohondriālās funkcijas izpēte, raksturojums un modelēšana pacientiem ar autiskā spektra traucējumiem”
• Iedzimtu neiromuskulāro slimību jaunu diagnostisko testu izstrade
• Riska faktoru nozīme Latvijas populācijā nesindromālas aukslēju, lūpas un/vai aukslēju šķeltnes attīstībā

Publikācijas

• Starptautiskas

• Robust genotyping tool for autosomal recessive type of limb-girdle muscular dystrophies I Iņaškina, Ē Jankevics, J Stāvusis, I Vasiļjeva, K Vīksne, Micule, I., Strautmanis, J., Naudina, M.S., Cimbalistiene, L., Kucinskas, V., Krumina, A., Utkus, A., Burnyte, B., Matuleviciene, A., B Lāce , Musculoskeletal Disorders, 17 (1), art. no. 1058 , 2016
• Sequencing the GRHL3 Coding Region Reveals Rare Truncating Mutations and a Common Susceptibility Variant for Nonsyndromic Cleft Palate Mangold, E., Böhmer, A.C., Ishorst, N., Hoebel, A.-K., Gültepe, P., Schuenke, H., Klamt, J., Hofmann, A., Gölz, L., Raff, R., Tessmann, P., Nowak, S., Reutter, H., Hemprich, A., Kreusch, T., Kramer, F.-J., Braumann, B., Reich, R., Schmidt, G., Jäger, A., , J Stāvusis, Ishida, M., Seselgyte, R., Moore, G.E., Nöthen, M.M., Borck, G., Aldhorae, K.A., B Lāce, Stanier, P., Knapp, M., Ludwig, K.U. , American Journal of Human Genetics, 98 (4), pp. 755-762 , 2016
• Analysis of possible genetic risk factors contributing to development of childhood acute lymphoblastic leukaemia in the Latvian population Kreile, M., Piekuse, L., Rots, D., Dobele, Z., Kovalova, Z., B Lāce , Archives of Medical Science, 12 (3), pp. 479-485 , 2016
• Genetic linkage studies of a North Carolina macular dystrophy family Audere, M., Rutka, K., I Iņaškina, R Pečulis, Sepetiene, S., Valeina, S., B Lāce , Medicina (Lithuania), 52 (3), pp. 180-186 , 2016
• CAV3 gene sequence variations: National Genome Database and clinics J Stāvusis, I Iņaškina, Ē Jankevics, I Radoviča-Spalviņa, Stavusis, J., Inashkina, I., Jankevics, E., Radovica, I., Micule, I., Strautmanis, J., Naudina, M.S., Utkus, A., Burnyte, B., B Lāce , Acta Neurologica Scandinavica , 2015
• Presentation of Complex Homozygous Allele in ABCA4 Gene in a Patient with Retinitis Pigmentosa Audere M, Rutka K, Šepetiene S., B Lāce , Case Rep Ophthalmol Med.; 2015:452068 , 2015
• Impact of the genes UGT1A1, GSTT1, GSTM1, GSTA1, GSTP1 and NAT2 on acute alcohol-toxic hepatitis. Piekuse L, B Lāce, Kreile M, Sadovska L, Kempa I, Daneberga Z, Mičule I, Sondore V, Keiss J, A Krūmiņa , Central European Journal of Biology. 9(2):125-130 , 2014
• HFE-related hemochromatosis risk mutations in Latvian population. R Pečulis, B Lāce, Putnina A, L Ņikitina-Zaķe, J Kloviņš , Ann Hematol. 94(2):343-4 , 2014
• Association between inherited monogenic liver disorders and chronic hepatitis C. Piekuse L, Kreile M, Zarina A, Steinberga Z, Sondore V, Keiss J, B Lāce, A Krūmiņa , World J Hepatol. 6(2):92-7 , 2014
• Genetic variation in the promoter region of beta-defensin 1 (DEFB 1) is associated with high caries experience in children born with cleft lip and palate. Krasone K, B Lāce, Akota I, Care R, Deeley K, Küchler EC, Vieira AR , Acta Odontol Scand. 72(3):235-40 , 2013
• Dupuytren's Contracture Cosegregation with Limb-Girdle Muscle Dystrophy. B Lāce, I Iņaškina, Micule I, I Vasiļjeva, Naudina MS, Strautmanis J, J Stāvusis, Ē Jankevics , Case Rep Neurol Med. 2013:254950. , 2013
• Clinical and biochemical features guiding the diagnostics in neurometabolic cutis laxa. Gardeitchik T, Mohamed M, Fischer B, Lammens M, Lefeber D, B Lāce, Parker M, Kim KJ, Lim BC, Häberle J, Garavelli L, Jagadeesh S, Kariminejad A, Guerra D, Leão M, Keski-Filppula R, Brunner H, Nijtmans L, van den Heuvel B, Wevers R, Kornak U, Morava E , Eur J Hum Genet. 22(7):888-95 , 2013
• Mitochondrial DNA origins of the Latvian clefting population Vieira AR, L Pliss, Pelena I, A Krūmiņa, V Baumanis, B Lāce , Mitochondrion 11(2):357-9. , 2011
• Association studies of candidate genes and cleft lip and palate taking into consideration geographical origin Lace B, Kempa I, Piekuse L, Grinfelde I, Klovins J, Pliss L, Krumina A, Vieira A , Eur J Oral Sci. [E-pub. ahead of print] , 2011
• Variation in FGF1, FOXE1, and TIMP2 genes is associated with nonsyndromic cleft lip with or without cleft palate. Nikopensius T, I Pole, Ambrozaitytė L, Jagomägi T, Saag M, Matulevičienė A, Utkus A, Krjutškov K, Tammekivi V, Piekuse L, Akota I, Barkane B, A Krūmiņa, J Kloviņš, B Lāce, Kučinskas V, Metspalu A , Birth Defects Res A Clin Mol Teratol 91(4):218-25 , 2011

• Vietēja mēroga

• Association of BMP4 polymorphisms with non-syndromic cleft lip with or without cleft palate and isolated cleft palate in Latvian and Lithuanian populations. Kempa I, Ambrozaitytė L, J Stāvusis, Akota I, Barkane B, A Krūmiņa, Matulevičienė A, Utkus A, Kučinskas V, B Lāce , Stomatologija, 16(3):94-101 , 2014
• Flux variability analysis approach of autism related metabolism in stoichiometric model of mitochondria. Pentjuss A, Rubenis O, Bauze D, Aprupe L, B Lāce , Biosystems and Information Technology Vol.2(2) 37-42 , 2013
• The Clinical Analysis of Patients with Autism and Autism Spectrum Disorders in Latvia Bauze D, Kevere L, Kronberga Z, Rizevs A, Dzalbs A, Daneberga Z, Locmele D, Andrezina R, B Lāce , Medical Basic Sciences , 2013
• Jaunas iespējas mitohondriālo slimību diagnostikā B Lāce, Krūmiņa Z, Piekuse L, Ē Jankevics, L Pliss, Timša L, Valeiņa S, A Krūmiņa , Latvijas Ārsts 7/8 28-31 , 2012
• Long-chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency in Latvia Krūmiņa Z, Daneberga Z, Piekuse L, Kreile M, Valeiņe S, B Lāce, Lugovska R , Proceedings of the Latvian Academy of Sciences , 2011

• Patenti

• A test kit for detecting mutations associated with Limb-Girdle Muscular Dystrophies Type-2 B Lāce, Ē Jankevics, I Iņaškina, I Vasiļjeva, J Stāvusis, Micule I, Naudina M, Strautmanis J. , European Patent Register EP2801621 , 2013

• Konferenču tēzes

• Side road of next generation sequencing data analysis B Lāce, Ē Jankevics, I Iņaškina, I Silamiķelis, J Stāvusis , A Magyar Humángenetikai Társaság X. Kongresszusa, Budapešta, Ungārija , 2014
• Genetic variants in SKI, FGFR1, WNT3, IRF6 and BMP4 genes are associated with risk for non-syndromic CL/CLP and/or CP in Latvian population Kempa L, Piekuse I, Akota B, Barkane A, A Krūmiņa, J Stāvusis, J Kloviņš, B Lāce , European Journal of Human Genetics, Volume 21, Suppl. 2. , 2013
• Pharmacogenetic Study of Second Generation Antipsychotic Therapy in Autism Spectrum Disorders Bauze D, Kevere L, Kronberga Z, Rizevs A, Viksna K, Andrezina R, B Lāce , European Journal of Human Genetics, Volume 21, Suppl. 2. , 2013
• A novel mutation in RYR1 causes severe congenital form of central core disease Micule I, Strautmanis J, Pronina N, B Lāce , European Journal of Human Genetics, Volume 21, Suppl. 2. , 2013
• Decade of raised awareness of neuromuscular diseases in Latvia B Lāce, I Iņaškina, Naudina S, J Stāvusis, I Vasiļjeva, Krumina Z, Pronina N, Micule I, Strautmanis J, Ē Jankevics , European Journal of Human Genetics, Volume 21, Suppl. 2. , 2013
• Limb-girdle muscle dystrophies mutation analysis in Latvian and Lithuanian patients using Illumina’s VeraCode GoldenGate Genotyping Assay I Iņaškina, J Stāvusis, I Vasiļjeva, Ē Jankevics, Micule I, B Lāce , European Journal of Human Genetics, Volume 21. Suppl. 2. , 2013
• NAT2 gene polymorphism influence on clinical outcome in acute alcohol induced toxic hepatitis. Piekuse L, Kreile M, B Lāce, Keiss J, Sondore V, A Krūmiņa , Proceedings of the Golden Helix Symposium “Genomic Medicine: Translating genes into health”, p23. , 2012
• SNP rs4132601 as a possible risk allele of acute lymphoblastic leukaemia development in children. Kreile M, Piekuse L, B Lāce, Kovalova Z, Medne G, Cebura E, Grutupa M, A Krūmiņa , European J Hum Gen, 20 Suppl. 1: p157-158. , 2012
• Study of gene Caveolin3 in Latvian population. J Stāvusis, B Lāce, I Iņaškina, Ē Jankevics, I Radoviča-Spalviņa , European J Hum Gen, 20 Suppl. 1: p391-392. , 2012
• Association of IRF6 gene polymorphisms with nonsyndromic cleft lip with or without cleft palate. Kempa I, Akota B, Barkane A, A Krūmiņa, J Kloviņš, B Lāce , European J Hum Gen, 20 Suppl. 1: p234. , 2012
• New non-invasive test for Limb Girdle Muscle Dystrophies type 2. B Lāce, I Iņaškina, Ē Jankevics, I Vasiļjeva, Naudina M, Strautmanis J, J Stāvusis, Micule I , European J Hum Gen, 2012, 20 Suppl. 1: p274. , 2012
• Limb Girdle muscle dystrophies mutation analysis using Illumina’s VeraCode GoldenGate Genotyping Assay. I Iņaškina, I Vasiļjeva, Ē Jankevics, J Stāvusis, Micule B, B Lāce , European J Hum Gen, 2012, 20 Suppl. 1: p274. , 2012
• BCL3 gene role in facial morphology. B Lāce, Kempa I, J Stāvusis, A Krūmiņa, Akota I, Barkāne B, Vieira A, Nagle E, Grinfelde I, Mauliņa I , Translation Genetics - Advancing Fronts for Craniofacial Health. Pittsburgh, USA. Abstracts, p12. , 2012
• Craniofacial pecualiarities in parents who have nonsyndromic cleft children. Nagle E, Grīnfelde I, Kažoka D, B Lāce , 5th Baltic genetic congress. Kauna. pp.9-10. , 2012
• Mutation spectrum of Wilson disease in Latvia A Zariņa, L Piekuse, M Kreile, A Krūmiņa, B Lāce, J Keiss, V Sondore, G Cernevska , Abstracts of the 4th International Congress of Molecular Medicine, In vivo, vol.25, No.3, p.574 , 2011

Ātrās saites

• BMC e-pasts
• Iepirkumi
• Iepirkumu arhīvs
• ES finansētie projekti 2014-2020
• ES finansētie projekti 2007-2013
• NFI finansētie projekti
• Masu medijiem