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Latvian Biomedical Research and Studies Centre launches new project "Clinical utility of extracellular vesicle-enclosed human and microbial transcriptomes”



On 1st April BMC will be launched European Regional Development Fund (ERDF) Operational Programme Growth and Employment 1.1.1 Specific Aid Objective to increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure Measure “Support for applied research” 2. Selection round.

"Clinical utility of extracellular vesicle-enclosed human and microbial transcriptomes” (Project Identification No The project principle investigator in BMC is Dr. biol. Aija Linē. Cooperation partner is SIA “GenEra”.

About the project:

We plan to expand and update the longitudinal Cancer Biobank comprising detailed clinical information, tumour tissue specimens, stool and blood samples from cancer patients. EVs will be isolated from plasma and stool samples of cancer patients and cancer-free controls and their RNA content will be sequenced together with small RNAs from matched tumour and normal tissues. Multiple data analyses will be performed to assess the correlation of EV-enclosed RNAs with various clinical and pathological features and to assess their diagnostic and prognostic value. Finally, digital PCR assays for selected biomarkers will be established and used to assess their clinical utility.

We expect, this project will lead to the discovery of novel RNA biomarkers of human and microbial origin that are associated with the presence, progression or drug response of cancer and are suitable for the development of blood-based tests. Currently, this technology is at TRL2 and we expect that at the end of the project it will reach TRL4.


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Mājas lapas izstrādi finansēja ERAF aktivitātes projekts Nr. 2010/0196/2DP/ "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".