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All International Local Patents Monographs Conference thesis
Name Authors Published in Year Internet
A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies D Gudrā, Shoaie, S.,, D Fridmanis, J Kloviņš, Wefer, H., I Silamiķelis, R Pečulis, I Kalniņa, I Elbere, I Radoviča-Spalviņa, Hultcrantz, R., Skenders, G., Leja, M., Engstrand, L Gut, . Article in Press. PMID: 30242040 2018
Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals. I Elbere, I Silamiķelis, M Ustinova, I Kalniņa, L Zaharenko, R Pečulis, Konrade I, Ciuculete DM, Zhukovsky C,, D Gudrā, I Radoviča-Spalviņa, D Fridmanis, Pirags V, Schiöth HB, J Kloviņš Clinical Epigenetics 2018
Synthesis and evaluation of (E)-2-(5-phenylpent-2 en-4-ynamido)cyclohex-1-ene-1-carblate derivatives as HCA2 receptor agonoxyists Bobileva, O., Ikaunieks, M., Duburs, G.,, I Mandrika, R Petrovska, J Kloviņš, Loza, E Bioorganic and Medicinal Chemistry, 25 (16), pp. 4314-4329 2017
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia McLaughlin, R.L., Schijven, D., J Kloviņš, L Ņikitina-Zaķe, O'Donovan, M.C Nature Communications, 8, art. no. 14774 2017
MIRU-VNTR genotype diversity and indications of homoplasy in M. avium strains isolated from humans and slaughter pigs in Latvia Kalvisa, A., Tsirogiannis, C., I Silamiķelis, Skenders, G., Broka, L., Zirnitis, A., I Jansone, R Ranka Infection, Genetics and Evolution, 43, pp. 15-21 2016
Variants in Pharmacokinetic Transporters and Glycaemic Response to Metformin: A MetGen Meta-Analysis Dujic, T., Zhou, K., Yee, S.W., van Leeuwen N., de Keyser, C.E., Javorský, M., Goswami, S., L Zaharenko, Marie, M., Christensen, H., Out, M., Tavendale, R., Kubo, M., Hedderson, M.M., van der Heijden, A.A., Klimčáková, L., V Pīrāgs, Kooy, A., Brøsen, K., J Kloviņš, Semiz, S., Tkáč, I., Stricker, B.H., Palmer, C.N., 't Hart, L.M., Giacomini, K.M., Pearson, E.R. Clinical Pharmacology & Therapeutics 2016
Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients L Zaharenko, I Kalniņa, Geldnere, K., Konrade, I., Grinberga, S., Židzik ,J., Javorský, M., Lejnieks, A., L Ņikitina-Zaķe, D Fridmanis, R Pečulis, I Radoviča-Spalviņa, Hartmane, D., Pugovics, O., Tkáč, I., Klimčáková, L., V Pīrāgs, J Kloviņš European Journal of Endocrinology 2016
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin Zhou, K., Yee, S.W., Seiser, E.L., Van Leeuwen, N., Tavendale, R., Bennett, A.J., Groves, C.J., Coleman, R.L., Van Der Heijden, A.A., Beulens, J.W., De Keyser, C.E., L Zaharenko, ., Rotroff, D.M., Out, M., Jablonski, K.A., Chen, L., Javorský, M., Zidzik, J., Levin, A.M., Keoki Williams, L., Dujic, T., Semiz, S., Kubo, M., Chien, H.-C., Maeda, S., Witte, J.S., Wu, L., Tká, I., Kooy, A., Van Schaik, R.H.N., Stehouwer, C.D.A., Logie,, J Kloviņš, V Pīrāgs, Hofman, A., Stricker, B.H., Motsinger-Reif, A.A., Wagner, M.J., Innocenti, F., Hart, L.M., Holman, R.R., McCarthy, M.I., Hedderson, M.M., Palmer, C.N.A., Florez, J.C., Giacomini, K.M., Pearson, E.R. Nature Genetics, 48 (9), pp. 1055-1059 2016
Functional Characteristics of Multipotent Mesenchymal Stromal Cells from Pituitary Adenomas K Megnis, I Mandrika, R Petrovska, Stukens, J., V Rovīte, Balcere, I., Jansone, L.S., R Pečulis, V Pīrāgs, J Kloviņš Stem Cells International, 2016, art. no. 7103720 2016
Polymorphisms in MEN1 and DRD2 genes are associated with the occurrence and characteristics of pituitary adenomas R Pečulis, Balcere, I., V Rovīte, K Megnis, Valtere, A., Stukens, J., Arnicane, L., L Ņikitina-Zaķe, Lejnieks, A., V Pīrāgs, J Kloviņš European Journal of Endocrinology, 175 (2), pp. 145-153 2016
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept Franke, B., Stein, J.L., Ripke, S., Anttila, V., Hibar, D.P., van Hulzen, K.J., Arias-Vasquez, A., Smoller, J.W., Nichols, T.E., Neale, M.C., McIntosh, A.M., Lee, P., McMahon, F.J., Meyer-Lindenberg, A., Mattheisen, M., Andreassen, O.A., Gruber, O., Sachd Nature Neuroscience, 19(3):420-31 2016
Schizophrenia risk from complex variation of complement component 4 Sekar, A., Bialas, A.R., de Rivera, H., Davis, A., Hammond, T.R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., Genovese, G., Rose, S.A., Handsaker, R.E., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Daly, M.J., C Nature, 530(7589):177-83 2016
Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness Bigdeli, T.B., Ripke, S., Bacanu, S.A., Lee, S.H., Wray, N.R., Gejman, P.V., Rietschel, M., Cichon, S., St Clair, D., Corvin, A., Kirov, G., McQuillin, A., Gurling, H., Rujescu, D., Andreassen, O.A., Werge, T., Blackwood, D.H., Pato, C.N., Pato, M.T., Mal American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 171B(2):276-89 2016
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study Johnson, E. C., D. W. Bjelland, D. P. Howrigan, A. Abdellaoui, G. Breen, A. Borglum, S. Cichon, F. Degenhardt, A. J. Forstner, J. Frank, G. Genovese, S. Heilmann-Heimbach, S. Herms, P. Hoffman, W. Maier, M. Mattheisen, D. Morris, B. Mowry, B. Müller-Mhyso PLoS Genetics, 12 (10), art. no. e1006343 2016
Robust genotyping tool for autosomal recessive type of limb-girdle muscular dystrophies I Iņaškina, Ē Jankevics, J Stāvusis, I Vasiļjeva, K Vīksne, Micule, I., Strautmanis, J., Naudina, M.S., Cimbalistiene, L., Kucinskas, V., Krumina, A., Utkus, A., Burnyte, B., Matuleviciene, A., B Lāce Musculoskeletal Disorders, 17 (1), art. no. 1058 2016
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Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".