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Role of natural killer cells in the therapeutic efficacy of oncolytic measles virus

 

 

Funding: European Regional Development Fund (ERDF) “On Implementation of Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment”

 

Project Title: „Role of natural killer cells in the therapeutic efficacy of oncolytic measles virus”

Project Nr.: 1.1.1.2/VIAA/2/18/292

Period: 36 month (1st October 2018 – 30 st September 2021)

Project costs: 133 806,00 EUR

Project implementer: Dr.rer.nat. Rūta Veinalde

Oncolytic viruses (OVs) are emerging as a multimodal, clinically relevant therapeutic option for cancer treatment. Stimulation of anti-tumor immunity of the host is one of the mechanisms of action of OVs. Natural killer (NK) cells are cytotoxic lymphocytes which are involved in recognition of malignant and virus-infected cells. The role of NK cell activation in OV therapy remains controversial. In this project molecular mechanisms of NK cell activation in the context of oncolytic measles virus (MV) infection will be investigated. Moreover, the role of the NK cell activity in MV therapy will be examined depending on the tumor microenvironment, specifically the MHC-I status. Based on the obtained results, options for rational NK cell modulation during MV therapy will be investigated with the aim to develop novel combination treatment strategies with increased therapeutic efficacy.

Information published 01.10.2018.



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".