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Role of miRNAs in the host-gut microbiome communication during metformin treatment in the context of metabolic disorders

 

 

Project Title: „Role of miRNAs in the host-gut microbiome communication during metformin treatment in the context of metabolic disorders”

Funding: European Regional Development Fund (ERDF), Measure 1.1.1.1 “Support for applied research” 

Project No.: 1.1.1.1/18/A/092

Period: 1 April 2019 – 31 March 2022

Project costs: 648 648 EUR

Principle Investigator: Dr. biol. Jānis Kloviņš

Cooperation partner: SIA “GenEra” 

 

Project summary:

Changes in core gut microbiome are associated with a wide variety of diseases, however, the mechanisms of interaction in the ability of the host to regulate these deviations are still unclear and under-investigated. Recently host miRNAs were shown to be involved in the communication between the host and its gut microbiome. There are still many caveats in the understanding of the possible mechanisms and the actual impact of observed association and further research is needed. Equally important is to understand the communication in relation to gut microbiome-related diseases such as type 2 diabetes (T2D) not only to understand the mechanisms of these phenomena in disease, but also to open opportunity for creation of completely novel therapeutic strategies.

The overall aim of the project is to investigate the contribution of the host miRNAs in metformin-mediated changes in gut microbiome composition and functions in the context of type 2 diabetes and to identify miRNAs which could be directed to potential clinical studies.

We will use notable sample resources collected in the framework of a previously performed mice experiment. In addition we will use samples from patients with different metabolic backgrounds obtained during colonoscopy procedure.

We will obtain gut metagenome and miRNA composition data by NGS and estimate the correlation between miRNA and gut microbiome profiles in high-fat diet-fed mice model and patients.

This project will result in a novel understanding of host miRNA-microbiome interaction in T2D and deliver new knowledge for development of personalized approaches in T2D treatment or improvement of the existing strategies.

Information published 01.04.2019.



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".