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Prostate cancer-derived extracellular vesicles as liquid biopsies and therapeutic targets

Project Title: Prostate cancer-derived extracellular vesicles as liquid biopsies and therapeutic targets

Project No: lzp-2018/1-0269

Period: 1st August 2018 – 31 July 2021

Project costs: 300 000 EUR

Principle Investigator: Dr. biol. Aija Linē

Collaboration: Asoc. prof. Vilnis Lietuvietis

 

Summary

The main aim of this project is to develop novel tools for the isolation of prostate cancer (PC)-derived EVs from human biofluids and to gain a deeper understanding into the RNA content and biodistribution of various PC-derived EV subsets and to assess the therapeutic potential of their depletion from the circulation.

This project is expected to generate antibodies against PC-specific EV surface markers and to characterise RNA content in PC-derived EV subpopulations, as well as assess the therapeutic potential of PC-derived EV depletion from the circulation. This will generate a solid basis for the development of clinically applicable diagnostic products for the detection of clinically significant PC and pave the way for the development of novel therapeutic strategies.

Information published 01.08.2018.



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".