Investigation of chemokine receptors CCR1 and CCR2 as potential diagnostic markers of B-cell malignancy progression
Title of the project: Investigation of chemokine receptors CCR1 and CCR2 as potential diagnostic markers of B-cell malignancy progression
Funding: Latvian Council of Science
Project number: 651/2014
Project manager: Dr.biol. A.Leončiks
The human chemokine C-C motif receptor CCR1 and CCR2 encoding genes are located within chromosome instability region (CIR) that is often silenced in human solid tumors. The first aim of the project is to validate whether expression of CCR1 and CCR2 is impaired in high-grade aggressive Burkitt’s lymphoma (BL) and non-aggressive chronic lymphocytic leukemia patients, and to investigate the biology of this impairment in order to estimate the potential clinical utility of CCR1 and CCR2 as prognostic markers. The second aim of the project is to select individual nucleotides-modified RNA-aptamers that were previously isolated against BL and non-malignant B-cell surface molecules and to investigate their potential diagnostic application.