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Identification of molecular determinants associated with the risk for various COVID-19 long term effects: a comprehensive cohort-based study in Latvian population

 

 

Project Title: „Identification of molecular determinants associated with the risk for various COVID-19 long term effects: a comprehensive cohort-based study in Latvian population. (POST-COVID-TRACK)”

Funding: European Regional Development Fund (ERDF), Measure 1.1.1.1 “Support for applied research”

Project No.: 1.1.1.1/21/A/029

Period: 1 January 2022 – 30 November 2023

Project costs: 500 000,00 EUR

Principle Investigator: Dr. biol.  Jānis Kloviņš

Cooperation partner: Pauls Stradiņš Clinical University Hospital

 

Project summary:

SARS-CoV-2 infection is a pandemic causing serious health and life threats at its acute phase and impacting the long-term health of post-COVID-19 patients, including multiorgan damage and various disease outcomes. It is estimated that around 80% of COVID-19 patients develop at least one of the long-term outcomes, while the detailed understanding of how infection and following recovery process is impacting these effects is not known. The goal of the project is to identify factors predicting and affecting the development of COVID-19 long-term effects by combining the omics-based data and clinical information in various cohorts of Latvian COVID-19 patients by a novel coronavirus with the impact on various concomitant diseases causing multiorgan damage and various disease outcomes. We will explore different omics-based data focusing on longitudinal changes in gene expression, metabolome, and cell-type-specific activity in samples obtained from COVID-19 patients at acute disease state and during the recovery period. We will use the large existing cohort of COVID-19 patients to access the most frequent post-covid symptoms and perform targeted recruitment of patients in specific disease areas to reach out for rare but more severe complications. We aim to increase the knowledge on molecular mechanisms leading to the development of COVID-19 related outcomes and identify new biomarkers that can be used for prevention and therapy optimization.

Information published 03.01.2022.



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".