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Functional programming of tumor-associated macrophages with viral immunotherapy vectors in breast cancer model

Project Title: Functional programming of tumor-associated macrophages with viral immunotherapy vectors in breast cancer model

Project No: lzp-2018/1-0208

Period: 1st August 2018 – 31 July 2021

Project costs: 300 000 EUR

Principle Investigator: Dr. biol. Anna Zajakina

 

Summary

The aim of this proposal is to develop a new strategy for targeted programming of TAMs using viral vectors, and to approve anti-cancer properties of the reprogrammed TAMs in advanced preclinical models. Alphaviral vectors, producing reprogramming cytokines, in combination with complementary effector molecules, will be applied for activation of TAM anti-cancer properties in a 3D environment using innovative heterotypic spheroid models of breast cancer. The conditions and supplementary factors for TAM programming will be identified and further assessed in immunocompetent mouse model and a patient derived xenograft model. The expected results will facilitate the development of a new immunotherapy platform based on targeted programming of the key components of tumour microenvironment with powerful virus gene delivery vectors. 

The Latvian Ministry of Education and Science Highlights Public Health as one of its priorities.  This project complies with the Public Health priority by addressing cancer therapy as one of the main health problems in Latvia and throughout the world. The proposed project has a high potential to benefit Public Health through the development of a novel therapeutic strategy for TAM reprogramming that could lead to the generation of an efficient supplementary therapy for solid tumours in future.

Information published 01.08.2018.



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".