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Enclosed lung on a chip system development suitable for respiratory disease research in BSL3 and microgravity systems (LoCBox)

 

 

Project Title: „Enclosed lung on a chip system development suitable for respiratory disease research in BSL3 and microgravity systems. (LoCBox)”

Funding: European Regional Development Fund (ERDF), Measure 1.1.1.1 “Support for applied research”

Project No.: 1.1.1.1/21/A/033

Period: 1 January 2022 – 30 November 2023

Project costs: 500 000.00 EUR

Principle Investigator: Prof. Arūrs Ābols

Cooperation partner: SIA"Cellboxlab"

 

Project summary:

This project aims to overcome technical challenges when working with organ on chip models in biological safety level 3 (BSL3) environment and microgravity by developing enclosed test system capable of cultivating cells and be compatible with BLS3 workflow and microgravity systems. Lung on chip model will be tested with pseudoviruses, SARS-Cov-2 and in microgravity device as a proof of principle study.  The following research activities are planned to be carried out during the project:

•           Enclosed system development (LoCBox)

•           LoCBox prototype testing with pseudoviruses 

•           LoCBox prototype testing with SARS-Cov-2

•           LoCBox prototype testing with microgravity device

•           Project management and result dissemination

The main outcomes of the project are: two prototypes for lung on chips cultivation and experiments in biological safety level 3 environment and microgravity. We expect that this project will lead to availability of state of art test model and put Latvian Biomedical Research and study center in leading position in technical capabilities for cutting edge research of coronavirus and COVID-19

Information published 03.01.2022.



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".