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Association of human intestinal and blood microbiome composition with general state of health and mortality within population of Latvia

 

 

Funding: European Regional Development Fund (ERDF) “On Implementation of Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment”

Project Title: Association of human intestinal and blood microbiome composition with general state of health and mortality within population of Latvia

Project No.: 1.1.1.2/VIAA/3/19/460

Period: 36 months (1 March 2020 – 28 February 2023)

Project costs: 133 806.00 EUR

Project implementer: Dr. biol. Dāvids Fridmanis

 

From microbiological point of view intestinal tract is very dynamic ecosystem, which is believed to be linked to blood microbiome. Latest discoveries revealed that alterations of microbial population in both sites are associated with various diseases. However there were only few studies that focused on their associations with general health status and there are no reports on association with mortality. The most probable reason to that is related to lengthiness of such studies, because years are needed for sample acquisition. Here in Latvia the collection of samples was started in 2013 and currently there are samples and detailed information from more than 7000 residents and 31 of these have died in non-violent death. Within the scope of this industrial study I shall perform intestinal metagenome and blood 16SrRNA sequencing on samples from 217 individuals. Our study group shall encompass six sample sets: control, deceased, autoimmune, intestinal cancer, cardiovascular and viral hepatitis. As the result of successful project implementation I shall uncover the elements of microbiome that are common to all or groups of case sets. The elements that are associated with decrease in survival could also be uncovered. These results might be applicable in development of various screening programs.

Information published 19.02.2020.

 

Project progress

 1 March 2020 – 31 May 2020

During this project period, work was started on the preparation of the project implementation related application for acquisition of medical ethics commission approval, these activities included assessment of available samples and available clinical and phenotypic information within the partner's collection, these activities also included considerations regarding which of the commissions (RAKUS or CMEK) the application should be sent. In parallel to these activities selection of samples and an in-depth study of the literature on the most appropriate blood microbiome isolation methods and the necessary the isolation process controls was performed .

Information published 31.05.2020. 




Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".