Research

Structural Biology, Biotechnology and Virusology

A. Zeltinsh lab

Andris Zeltiņš , Dr. biol.

Head of the Scientific Council
Phone: +371 67808200
E-mail: anze@biomed.lu.lv

Scientific Staff

Publications

• International

• Active vaccination against interleukin-5 as long-term treatment for insect-bite hypersensitivity in horses Fettelschoss-Gabriel, A., Fettelschoss, V., Olomski, F., Birkmann, K., Thoms, F., Bühler, M., Kummer, M.,, A Zeltiņš, Kündig, T.M., Bachmann, M.F , Allergy: European Journal of Allergy and Clinical Immunology, . Article in Press. PMID: 30402930 , 2018
• Synthesis and immunological evaluation of virus-like particle-milbemycin A3/A4 conjugates A Zeltiņš, Turks, M, D Skrastiņa, Lugiņina, J, I Kalnciema, I Baļķe, Bizdēna, Ē., Skrivelis, V , Antibiotics, 6 (3), art. no. 18 , 2017
• Incorporation of Tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer’s and cat allergy A Zeltiņš, West J., Zabel F., El Turabi A.,, I Baļķe, Haas S., Maudrich M, Storni F., Engeroff P., Jennings G.T., Kotecha A., Stuart D.I., Foerster J., Bachmann M.F. , npj Vaccines, 2, Article number: 30. , 2017
• Magnetic microrods as a tool for microrheology Brasovs, A., Cimurs, J., Erglis, K., A Zeltiņš, Berret, J.-F., Cebers, A. , Soft Matter, 11 (13), pp. 2563-2569 , 2015
• Viral Nanoparticles: Principles of Construction and Characterization A Zeltiņš , Viral Nanotechnology, pages 93 -120 , 2015
• Occurrence and Diversity of Pome Fruit Viruses in Apple and Pear Orchards in Latvia N Pupola, I Morocko-Bicevska, A Kale, A Zeltiņš , Journal of Phytopathology, 159(9): 597-605 , 2011
• Potato Virus Y-Like Particles as a New Carrier for the Presentation of Foreign Protein Stretches I Kalnciema, D Skrastiņa, V Ose-Klinklāva, P Pumpēns, A Zeltiņš , Mol Biotechnol. Dec 14. [Epub ahead of print]. , 2011
• Gelation of semiflexible polyelectrolytes by multivalent counterions Huisman EM, Wen Q, Wang YH, Cruz K, Kitenbergs G, Erglis K, A Zeltiņš, Cebers A, Janmey PA , Soft Matter, 7: 7257-61 , 2011
• Crystal structure of human gamma-butyrobetaine hydroxylase. K Tārs, J Rūmnieks, A Zeltiņš, A Kazāks, S Koteloviča, A Leončiks, J Šaripo, Viksna A, Kuka J, Liepinsh E, Dambrova M , Biochem Biophys Res Commun. 398(4):634-9 , 2010
• The Ryegrass mottle virus genome codes for a sobemovirus 3C-like serine protease and RNA-dependent RNA polymerase translated via -1 ribosomal frameshifting I Baļķe, G Reseviča, A Zeltiņš , Virus Genes 35(2):395-8. , 2007
• Dynamics of magnetotactic bacteria in a rotating magnetic field. Erglis K, Wen Q, V Ose-Klinklāva, A Zeltiņš, Sharipo A, Janmey PA, Cebers A , Biophys J. 93(4):1402-12 , 2007
• The three-dimensional structure of ryegrass mottle virus at 2.9 A resolution. Plevka P, K Tārs, A Zeltiņš, I Baļķe, Truve E, Liljas L , Virology 369(2):364-74. , 2007

• Local

• Expression and characterization of the Ryegrass mottle virus non-structural proteins I Baļķe, G Reseviča, D Skrastiņa, A Zeltiņš , Proc. Latvian Acad. Sci., Section B 64(5/6) , 2010
• Viscoelasticity of the bacteriophage Pf1 network measured by magnetic microrheology. Erglis K, V Ose-Klinklāva, A Zeltiņš, Cebers A , Magnetohydrodynamics 46: 3–9 , 2010

• Patents

• COUPLING OF BORRELIAL PROTEIN BB0689 TO VIRUS-LIKE PARTICLES FOR GENERATION OF LYME DISEASE VACCINE K Tārs, I Petrovskis, A Dišlers, D Skrastiņa, A Zeltiņš, K Brangulis, S Koteloviča , Europena Patent Office, Application number EP15182845.6 , 2015
• Daudzziedu airenes raibuma vīrusam līdzīgo daļiņu iegūšana A Zeltiņš, I Baļķe, G Reseviča, V Ose-Klinklāva, A Kazāks, J Freivalds , LR patents LV15006 , 2013
• Upeņu reversijas vīrusa antigēnu iegūšana A Zeltiņš, I Baļķe, J Šaripo, I. Moročko-Bičevska, D Skrastiņa , LR patents LV 15018 , 2013
• Kartupeļu vīrusam PVM līdzīgo daļiņu iegūšana A Zeltiņš, I Kalnciema, V Ose-Klinklāva, I Baļķe , LR patents LV 15007 , 2013
• Heterologas proteīnu sekvences eksponējošu kartupeļu vīrusam PVY līdzīgo daļiņu iegūšana un izmantošana. A Zeltiņš, I Kalnciema, D Skrastiņa, V Ose-Klinklāva, P Pumpēns , LR patents Nr. 14204 , 2010

• Monographs

• Plant virus biotechnology platforms for expression of medicinal proteins. /in "Medicinal Protein Engineering." pp. 481-517 A Zeltiņš , CRC Press, Taylor & Francis Group, Boca Raton London, New York , 2009

• Conference thesis

• Purification and analysis of integrity and components of VLPs A Zeltiņš , Virus-like particles (VLPs)as vaccines, vectors and adjuvants, Annecy, Francija , 2014

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