Research Directions and labs
Research
molecular pharmacology and drug targets

A. Leonchiks lab

Ainārs Leončiks , Dr. biol.

Senior researcher
Phone: +371 67808007
E-mail: ainleo@biomed.lu.lv

Research

The main research area of our group is a high-throughput screening of focused small-molecule libraries, evaluation of candidate inhibitors and structure-based optimization of hit/lead compounds.

The first group of targets are sortase A (SrtA) inhibitors for antimicrobial therapy. Our research efforts are directed at finding and developing more effective and selective therapeutic agents against multi-resistant Gram+ pathogens with the minimal risk of developing antibiotic-resistant infections.

The other group of compounds that we investigate are potential anticancer agents as drug candidates for the treatment of metastasis and angiogenesis inhibition (MMP inhibitors), and as the diagnostic test markers for the detection of malignant B-cells in blood (RNA aptamers). 

Scientific Staff

Marija Teveļeva , Dr. biol.

Marija Teveļeva , Dr. biol.

Researcher
Phone: +371 67808007

Žanna Rudevica , zh_rudevica@inbox.lv

Žanna Rudevica

Researcher
Phone: +371 67808007
E-mail: zh_rudevica@inbox.lv

Jeļena Šaripo , MSc. biol., jelena.saripo@biomed.lu.lv

Jeļena Šaripo , MSc. biol.

Assistant
Phone: +371 67808007
E-mail: jelena.saripo@biomed.lu.lv

Viktorija Kurbatska , MSc. biol., vkurbatska@gmail.com.

Viktorija Kurbatska , MSc. biol.

Research assistants
Phone: +371 67808007
E-mail: vkurbatska@gmail.com.

Cooperation partners

  • Dr. Kristaps Jaudzems, Dr. Grigory Veinberg, Latvian Institute of Organic Synthesis
  • Dr. Irina Holodnuka Kholodnyuk, Riga Stradins University/Karolinska Institutet
  • Dr. Domenico Schillaci, Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Università degli Studi di Palermo

Publications


All publications

Quick links

Group quick links

Current Projects


All group projects


Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".